Clinical trials: Labour
Breech Presentation
Early External Cephalic Version (ECV) 2 Trial
For women with a fetus in breech presentation, does early ECV (at 34 0/7 up to 35 weeks and 6/7 days) versus delayed ECV (not before 37 weeks and 0/7 days) increase or decrease the likelihood of cesarean section (CS)?
- Trial name
- NCT00141687
- Testing
- Early ECV between 34 0/7 and 35 6/7 weeks, Delayed ECV at or after 37 0/7 weeks
- Where
- Canada
- Volunteers
- 1,543 people
- Sponsor
- McMaster University
Preterm Labour
Detection of Preterm Labour by Cervical Length
Detection of short cervix by transvaginal ultrasound and its evidence based management to prevent preterm birth .
- Trial name
- NCT04104984
- Testing
- transvaginal ultrasound, Progesterone Vaginal Suppository, cervical cercalage
- Volunteers
- 966 people, healthy volunteers welcome
- Sponsor
- Assiut University
Failed Induction, Cervical Dystocia
Transvaginal Sonographic Measurement of Cervical Length Versus Bishop Score in Induction of Labour for Prediction of Caesarean Delivery.
Transvaginal sonographic measurement of cervical length versus Bishop score in labour induction at term for prediction of Caesarean delivery. This study is prospective study.
- Trial name
- NCT03430804
- Testing
- Bishop score calculation of modified Bishop score in numbers by digital vaginal examination
- Where
- Egypt
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Nitrous Oxide, Labour Analgesia
Nitrous Oxyde During Labour
1. Background to the clinical research project Nitrous oxide is a valuable tool in medicine for its rapid and effective analgesic and sedative properties. It is used in 50% gaseous form for painful procedures.
- Trial name
- NCT06595303
- Testing
- Nitrous oxide for labour analgesia
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Erasme University Hospital
Perineal Trauma, Postpartum Pain
RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy
Perineal tears and episiotomies are common after vaginal birth and may cause persistent pain, impaired wound healing, pain during sexual activity, and concerns about genital appearance.
- Conditions
- Perineal Trauma, Postpartum Pain, Episiotomy, Perineal Laceration
- Trial name
- RELIEVE (NCT07727213)
- Testing
- Autologous Non-Activated Platelet-Rich Plasma, Saline (0.9%, sterile, for infusion)
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Pelvic Exam, Pelvis
Anthropometric Measurements on Size and Labour Outcomes
This study aims to evaluate women's physical body measurements and externally measurable pelvis measurements and determine their impact on labor pain level, duration of labor, and mode of delivery.
- Conditions
- Pelvic Exam, Pelvis, Delivery Mode, Midwife
- Trial name
- Pelvis (NCT07173452)
- Testing
- vaginal examination, physical body measurements, transvaginal ultrasonographic
- Where
- Turkey (Türkiye)
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Failed Labour
Comparison of Pre-Induction Cervical Ripening
This study is designed to assess the effectiveness of a combination method of induction of labor using a urinary balloon catheter and prostaglandin gel.
- Trial name
- NCT01390233
- Testing
- Prepidil Gel, Urinary Balloon Catheter, Combined Urinary Catheter & Prepidil Gel
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of South Carolina
Caesarean Section
Current Dutch Practice on Caesarean Sections: Identification of Barriers and Facilitators for Optimal Care
Caesarean (CS) delivery rates in the Netherlands increased from 5 to 15% the last 20 years. CSs have no clear benefit for overall neonatal outcome and are associated with higher maternal complications and high costs.
- Trial name
- SIMPLE (NCT01261676)
- Testing
- Implementation aids
- Where
- 20 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Maastricht University Medical Center
Labor Complication, Cervix
Comparison of Two Rhythm of Administration of Prostaglandin Gel for Induction of Labor
The study compares two rhythms of administration of prostaglandin vaginal gels for cervical priming before induction of labor in term patients.
- Trial name
- GELFREQ (NCT04413890)
- Testing
- Dinoprostone vaginal gel
- Where
- Martinique
- Volunteers
- 268 people
- Sponsor
- University Hospital Center of Martinique
Preterm Labor, Preterm Birth
The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth
Preterm birth (PTB) is the primary cause of infant death worldwide. It has been shown that a vaginal microbiota deplete in Lactobacillus species is a risk factor for preterm labour.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Premature Rupture of Membrane, Cervical Incompetence
- Trial name
- NCT03992534
- Testing
- LACTIN-V
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Heart; Disease,Complicating Pregnancy, Pre-existing
Elective Induction vs Spontaneous Labour in Patients With Heart Disease
Fifty pregnant patients with acquired and congenital heart disease between 38-41 weeks were randomised into elective induction and spontaneous labour groups only after bishop score was equal to or more than 6.It was concluded…
- Trial name
- NCT01677364
- Testing
- Oxytocin
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Induction of Labour
Comparison of the Effectiveness, Safety, and Satisfaction of Different Methods for Labor Induction
The objective of this interventional study is to compare the effectiveness, safety, and patient satisfaction associated with two commonly used methods of labor induction: low-dose oral misoprostol and the vaginal delivery system…
- Trial name
- NCT06794385
- Testing
- dinoprostone vaginal delivery system, low dose peroral misoprostol
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana
Pain Relief at First Stage
Pain Relief by Applying TENS on Acupuncture Points During the First Stage of Labour
We aimed to establish the reduction of labor pain by applying TENS at acupuncture points during the first stage of labour, to assess their efficacy, and to ascertain their acceptability.
- Trial name
- NCT00148577
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Induction of Labour, Labour, Induced
Misoprostol Labour Induction Study
Labour induction is a frequent obstetric intervention (~20%). Prostaglandins (PGs) are effective agents, but gastrointestinal (GI) intolerance has limited use to non-oral routes.
- Trial name
- NCT03489928
- Testing
- Oral Misoprostol, Vaginal Misoprostol, Dinoprostone
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- David Young
Induction of Labour
Women's Knowledge About Induction of Labour and Its Association With Their Experience
Induction of labour (IOL) is a common procedure to initiate childbirth, around one in three pregnant women having their labour induced in the UK.
- Trial name
- INFORM (NCT07616765)
- Testing
- Survey and Interview-Based Assessment
- Volunteers
- 112 people
- Sponsor
- Imperial College London
Induction of Labor, Cervical Ripening
Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)
Premature rupture of membranes (PROM) at term complicates 6 to 22% of singleton pregnancies. Spontaneous labour occurs in 60-67% of these patients within 24h.
- Conditions
- Induction of Labor, Cervical Ripening, Premature Rupture of Fetal Membranes, Nulliparous
- Trial name
- RUBAPRO2 (NCT05568745)
- Testing
- Balloon for cervical ripening (Teleflex French Dufour catheter CH20 reference 174000), Oxytocin, Misoprostol Oral Tablet
- Where
- 5 sites in France
- Volunteers
- 152 people
- Sponsor
- University Hospital, Clermont-Ferrand
Safety, Efficacy
Misodel or Angusta for Induction of Labour?
In Denmark, every 4 birth induced, most often due to prolonged pregnancy, up til 10-12 days after term. A group (RADS) set up by the Danish Regions has recently recommended induction with prostaglandins in tablet form (Angusta®).
- Conditions
- Safety, Efficacy, Cost, Experience
- Trial name
- NCT02693587
- Testing
- Misodel and Angusta
- Where
- Denmark
- Volunteers
- 420 people
- Sponsor
- Holbaek Sygehus
Labor Analgesia
Anesthesia Clinical Practice During Labour Neuraxial Analgesia
The goal of this observational study is to evaluate the communication between the anesthesiologist and the patient prior the initiation and during the administration of the labor neuraxial analgesia.
- Trial name
- ACP-LNA (NCT07083167)
- Testing
- No Interventions.
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Labour,Induced
Oral Misoprostol Solution in Labor Induction
This study compares safety and efficacy between repetitive hourly dose of oral misoprostol and two hourly dose oral regimens for cervical ripening and labor induction.
- Trial name
- NCT03927807
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Premature Birth
Prediction Tool for Premature Labour and Neonatal Outcome
A register and prediction model will be developed to predict the outcome of preterm labour and birth.
- Trial name
- PRETURN (NCT03405116)
- Where
- Belgium
- Volunteers
- 2,037 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent