Clinical trials: Lacerations
Corneal Topography, Dry Eye Syndromes
Performance Evaluation of the OCUTOP Hand-held Corneal Topographer
The OCUTOP is a new hand-held camera that photographs the front of the eye to map the shape of the cornea and to assess the tear film.
- Conditions
- Corneal Topography, Dry Eye Syndromes, Keratoconus, Healthy Volunteers
- Trial name
- OCUTOP (NCT07895849)
- Testing
- OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment)
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Dry Eye Syndrome
Tears Substitutions and Their Effects on Higher Order Aberrometery
Hypothesis is that tear substitutions cause blur after they are instilled. The investigators will use aberrometry as a measurement over time after a tear formulation is used and try to determine if there are any measurable change…
- Trial name
- NCT00812721
- Testing
- Preservative Free Saline, Optive, Refresh Moderate/Severe
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gina Rogers
Dysfunctional Tear Syndrome
Clinical Evaluation of the InflammaDry Device for Detecting Dry Eye
InflammaDry is a rapid diagnostic test for the detection of elevated levels of Matrix Metalloproteinase-9 (MMP-9) protein in tear fluid.
- Trial name
- NCT01692964
- Testing
- InflammaDry
- Where
- 4 sites in United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Rapid Pathogen Screening
Dry Eye Syndromes
Assessment of TFT by OCT in Healthy Subjects and Subjects With DES
Dry eye syndrome (DES) is a highly prevalent ocular condition with potential severe consequences for affected patients. DES can be either caused by decreased tear production or increased tear evaporation, both leading to an…
- Trial name
- NCT02585414
- Where
- Austria
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dry Eye Disease
Evaluating the Efficacy of Dry Eye (DE) Disease Treatment Using Novel Tear Film Imager (TFI)
Dry Eye disease signs and symptoms are reduced in patients who receive topical steroids and topical hyaluronic acid. AdOM's Tear Film Imager measurements are reproducible and it can diagnose the dry eye disease state in a single…
- Trial name
- NCT04670263
- Testing
- Tear Film Imager
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Adom Advanced Optical Technologies Ltd.
Alzheimer Disease
The TearAD Study: Tear Biomarkers for Alzheimer's Disease (AD) Screening and Diagnosis
The goal of this observational longitudinal study is to investigates whether tear fluid is a non-invasive source of biomarkers for Alzheimer's disease.
- Trial name
- TearAD (NCT05655793)
- Testing
- Tear Fluid collection (Schirmer's strip), Retinal imaging
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Second Degree Perineal Tear During Delivery - Delivered, Episiotomy; Complications
Perineal Local Infiltration Study
The prevalence of birth canal lacerations is more than 70% of all deliveries in Canada. The repair of such lacerations is usually done using a pre-existing epidural analgesia.
- Conditions
- Second Degree Perineal Tear During Delivery - Delivered, Episiotomy; Complications, Anesthesia, Local
- Trial name
- PLIS (NCT03672500)
- Testing
- Bupivacaine 0.5%+Epinephrine 50mc
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Rotator Cuff Tear
Load-induced Changes in Glenohumeral Translation in Patients With Rotator Cuff Tear
The study is to investigate the dose-response relationship between load-induced muscle activation (liMA) and load-induced glenohumeral translation (liTr) in patients with rotator cuff tears and asymptomatic control subjects.
- Trial name
- LiTrans (NCT04819724)
- Testing
- 3D motion analysis, isometric shoulder strength by dynamometer, fluoroscopic images of each shoulder
- Where
- Switzerland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Perineal Trauma
Ward-Level Implementation and Post-Market Clinical Follow-up Study of ASISU Under Routine Clinical Practice
This is a single-center, prospective, non-randomized post-market clinical follow-up study evaluating the implementation and clinical performance of ASISU during routine vaginal childbirth.
- Trial name
- ASISU-PMCF (NCT07844005)
- Testing
- Perineal protection device
- Where
- Denmark
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- oasicare ApS
Fourth Degree Perineal Laceration Involving Anal Mucosa, Obstetric; Injury
Use of the Modified Beef Tongue Model for Teaching Repair of Obstetrical Fourth-Degree Laceration to Residents
This is a study evaluating the use of the modified beef tongue model for teaching repair of obstetrical fourth-degree laceration to residents.
- Conditions
- Fourth Degree Perineal Laceration Involving Anal Mucosa, Obstetric; Injury, Obstetric Labor Complications
- Trial name
- NCT03341351
- Testing
- Instructional video, Instructional workshop
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Perineal Tear, Delivery; Trauma
The Patient Positioning for Perineal Protection Study
It is common practice for practitioners to instruct patients to forcibly flex the hips at the time of delivery of the fetal vertex.
- Conditions
- Perineal Tear, Delivery; Trauma, Perineal Laceration
- Trial name
- 4P (NCT04616170)
- Testing
- Hip extension, Usual Care
- Where
- United States
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Graves' Orbitopathy, Thyroid Eye Disease, TED
Early Risk Stratification of Thyroid Eye Disease in Newly Diagnosed Graves' Disease
The aim of this observational study is to investigate why some people with newly diagnosed Graves' disease (GD) develop thyroid eye disease (TED), also known as Graves' orbitopathy, while others do not.
- Conditions
- Graves' Orbitopathy, Thyroid Eye Disease, TED, Graves' Disease
- Trial name
- SOGO (NCT07812194)
- Testing
- Study-related ophthalmological assessment and biospecimen collection, Blood biomarkers and standardized blood samples including thyroid function status
- Where
- Denmark
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Keratoconjunctivitis Sicca
Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points
To evaluate tear film stability of a market lubricant therapeutic eye drop versus saline when using Evaporometry and Interferometry in patients with a diagnosis of Keratoconjunctivitis Sicca (KCS).
- Trial name
- NCT00345241
- Testing
- Systane Ocular Drops (OTC)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Tear Film Characteristics
Quantifying Ocular Surface Aberrations After Tear Film Interventions
The CA-800 Corneal Analyzer (Visia Imaging S.R.L., Italy) is a device that can measure small imperfections in the tear film when the eyes are open.
- Trial name
- GAMBIA (NCT06966349)
- Testing
- Systane Complete Preservative-Free, Senofilcon A, Somofilcon A
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Pain, Intravitreal Injection
Pain Reduction With Topical Bromfenac Versus Artificial Tear After Intravitreal Injection.
The purpose of this prospective interventional study is to compare post-intravitreal injection pain between eyes receiving topical bromfenac versus artificial tears as an analgesic after intravitreal injection.
- Conditions
- Pain, Intravitreal Injection, Pain, Acute
- Trial name
- NCT06130384
- Testing
- Use of bromfenac 0.09% to reduce intravitreal injection pain, Use of artificial tears to reduce intravitreal injection pain
- Where
- 5 sites in United States, Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Meniscal Tear
Nanoscope Cost Analysis Study
The study is a pilot study designed to generate preliminary data regarding the cost of partial meniscectomy using NanoScope versus conventional arthroscopy in a traditional operating room (OR) setting
- Trial name
- NCT06603740
- Testing
- Arthrex Nanoscope, Conventional Arthroscopy without Arthrex Nanoscope
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Arthrex, Inc.
White Blood Cells
Study of the Cell Response in the Tear Film After Overnight Contact Lens Wear
The purpose of this study was to count and analyze the white blood cells in tear samples collected from study participants following sleep.
- Trial name
- CORNWALL (NCT01379768)
- Testing
- Lotrafilcon A contact lens, Lotrafilcon B contact lens, Clear Care Cleaning and Disinfection Solution
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CIBA VISION
Ocular Surface Disease, Dry Eye Syndrome (DES)
This is a Single Center, Open-label Prospective Study to Evaluate the Effect of Xiidra® (Lifitegrast Ophthalmic Solution 5.0%) on Tear Film Biomarkers in Dry Eye
This is a single-center prospective open-label, clinical trial to explore proteomic expression of tear fluid biomarkers in patients with dry eye treated with Lifitegrast.
- Trial name
- NCT07490535
- Testing
- (Xiidra®) Lifitegrast Ophthalmic Solution 5.0%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pittsburgh Research Institute
Patellofemoral Pain Syndrome, ACL Tear
Kinematic Assessment of Human Peripheral Joints by Dynamic CT
Aim of the research project: The entire research project aims to investigate human peripheral joints (knee, foot \& ankle, elbow, wrist \& hand) by dynamic 4D radiographic imaging acquisition during real-time motion.
- Trial name
- Karma-4D (NCT04732585)
- Testing
- Physiotherapy or Surgery
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery
One technique for the nerve block involves injecting the numbing medicine where the nerve is together (higher up in the back of the thigh).
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot
- Trial name
- NCT01550094
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD