Clinical trials: Lacrimal Duct Obstruction
Epiphora, Dacryocystorhinostomy
SLlt Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction
This project aims to test whether a newly designed lacrimal stent - the SlitStent - when placed into the lacrimal system in the standard fashion following a DCR surgery, will provide good symptomatic relief for epiphora and be…
- Trial name
- SLINDO (NCT03705000)
- Testing
- Slit Stent II, BIKA for DCR
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Thomas Gardner
Nasolacrimal Duct Obstruction
Monocanalicular Versus Bicanalicular Intubation in the Treatment of Congenital Nasolacrimal Duct Obstruction
The aim of the study was to compare the success rate of monocanalicular intubation versus bicanalicular silicone intubation in congenital nasolacrimal duct obstruction in children aged between 10 and 36 months.
- Trial name
- MCI_vs_BCI (NCT01233596)
- Testing
- Canalicular intubation
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- University Hospital Ostrava
Nasolacrimal Duct Obstruction
The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study
The most important symptoms of nasolacrimal duct obstruction are excessive tearing and mucoid discharge. The proposed treatment in this regard is dacryocystorhinostomy (DCR) surgery.
- Trial name
- NCT06346561
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Lacrimal Apparatus Diseases, Lacrimal Duct Obstruction
Analysis of 86 Dacryoliths at the University Hospital Ostrava
Background Because dacryoliths occur at low frequency, few studies have focused on their composition. The investigators aimed to present findings from morphological, chemical, and mineralogic analysis of 86 dacryoliths.
- Trial name
- NCT01826734
- Where
- Czechia
- Volunteers
- 86 people
- Sponsor
- University Hospital Ostrava
Nasolacrimal Duct Obstruction
Study of Primary Surgical Treatment of Nasolacrimal Duct Obstruction in Children Less Than Four Years Old
The purpose of this study is: To report the success proportions of simple probing within different age groups of patients under 24 months of age.
- Trial name
- NLD1 (NCT00315289)
- Testing
- Nasolacrimal balloon catheter duct dilation, Nasolacrimal intubation, Simple Nasolacrimal duct probing
- Where
- 2 sites in United States
- Volunteers
- 973 people
- Sponsor
- Jaeb Center for Health Research
Glaucoma, Ocular Hypertension
Safety, Tolerability and Preliminary Efficacy of Unilateral Latanoprost-loaded Punctual Plug -EXP-LP
Glaucoma is the most frequent cause of irreversible \& preventable blindness worldwide, affecting about 2% of the world's population in people over 40.
- Conditions
- Glaucoma, Ocular Hypertension, IOP
- Trial name
- EXP-LP (NCT03318146)
- Testing
- drug delivery system, XALATAN®
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shaare Zedek Medical Center
Lacrimal Duct Obstruction, Lacrimal Apparatus Diseases
Closed Dacryointubation vs Bicanalicular Intubation for Proximal Tear Duct Obstruction
In Mexico, upper lacrimal duct obstruction (ULDO) is a common pathology, and the standard surgical treatment is closed dracryointubation.
- Conditions
- Lacrimal Duct Obstruction, Lacrimal Apparatus Diseases, Lacrimal Stenosis, Lacrimal Elimination
- Trial name
- DICvsBIcanal (NCT06428266)
- Testing
- Bicanalicular intubation, Closed dacryointubation
- Where
- Mexico
- Volunteers
- 31 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Primary Acquired Nasolacrimal Duct Obstruction
Efficacy Evaluation of 5-Fluorouracil as an Adjuvant to Endoscopic Dacryocystorhinostomy in Managing Primary Acquired Nasolacrimal Duct Obstruction With Small Lacrimal Sac: A Randomized Controlled Study
Primary acquired nasolacrimal duct obstruction (PANDO) is a lacrimal duct obstruction disease characterized by inflammatory fibrosis of the nasolacrimal duct, with primary symptoms including epiphora and increased secretions…
- Trial name
- NCT07154121
- Testing
- 5-fluorouracil group, saline group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Canalicular Obstruction
Self-retaining Bicanalicular Intubation Stent Versus Bicanalicular Silicone Tube for Management of Canalicular Obstruction
The aim of the study is to evaluate outcomes of the use of self_retaining intubation set versus bicanalicular silicone tube in management of canalicular obstruction
- Trial name
- NCT04706117
- Testing
- Self-retaining bicanalicular intubation stent
- Volunteers
- 40 people
- Sponsor
- Minia University
Lacrimal Duct Obstruction
Outcomes of Early Lacrimal Probing Versus Lacrimal Sac Massage in Infants With Congenital Nasolacrimal Duct Obstruction
This study aims to provide evidence on the optimal timing and efficacy of lacrimal probing in infants with congenital NLDO to minimize morbidity and healthcare costs .
- Trial name
- NCT07593469
- Testing
- naslacrimal duct probing
- Volunteers
- 50 people
- Sponsor
- Hany Mahmoud,MD
Nasolacrimal Duct Obstruction, Epiphora
Outcomes of Stentless Dacryocystorhinostomy in Primary Acquired Nasolacrimal Duct Obstruction.
This prospective, single-arm interventional clinical study aims to evaluate the short- and intermediate-term anatomical, functional, and quality-of-life outcomes of primary stentless endoscopic dacryocystorhinostomy (En-DCR) in…
- Trial name
- NCT07848932
- Testing
- Stentless Endoscopic Dacryocystorhinostomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Nasolacrimal Duct Obstruction, Nasolacrimal Tract Obstruction
Portable Endoscopic Camera System Using Modified Action Camera for Endoscopic Sinunasal Examination
This study is designed to compare two methods for performing a nasal endoscopic examination used in the evaluation of excessive watering or tearing of the eyes.
- Trial name
- NCT07289854
- Testing
- Modified Portable Endoscopic Camera
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Arkansas
Lacrimal Duct Obstruction
Endoscopic Dacryocystorhinostomy Prospective Research
Endoscopic dacryocystorhinostomy (EN-DCR) is an effective procedure when treating saccal and postsaccal obstructions of the nasolacrimal pathway. The benefit of silicone tubing after DCR is still controversial.
- Trial name
- NCT00571129
- Testing
- DCR with no tubes or mitomycin
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Kuopio University Hospital
Nasolacrimal Duct Obstruction
Immediate Office Probing vs Deferred Facility Probing for Nasolacrimal Duct Obstruction in Children 6 to <10 Months Old
The purpose of this study is: To determine the cost-effectiveness of treating NLDO using immediate office probing compared with deferred probing in a facility setting.
- Trial name
- NLD3 (NCT00780741)
- Testing
- Immediate Office Probing, Deferred Facility Probing
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Jaeb Center for Health Research
Neonatal Dacryocystitis, Congenital Nasolacrimal Duct Obstruction
Efficacy and Safety of Piclosept in the Complex Treatment of Neonatal Dacryocystitis
This single-center, prospective, randomized, controlled, assessor-blinded study will evaluate the efficacy and safety of Piclosept® ophthalmic solution as an adjunct to standardized lacrimal sac massage in children aged 1 to 12…
- Trial name
- NCT07875517
- Testing
- Picloxidine, Levofloxacin, Standardized lacrimal sac massage
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- Kazakh Eye Research Institute
Nasolacrimal Duct Obstruction, Thyroid Cancer
Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer
The association of radioiodine therapy for the treatment of thyroid cancer with nasolacrimal duct obstruction has been well documented in the medical literature.
- Trial name
- NCT05999630
- Testing
- Artificial Tears Methylcellulose
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center