Clinical trials: Lactate Blood Increase
Septic Shock
Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148
Septic shock is a potentially life-threatening condition that can result in multi-organ dysfunction syndrome (MODS) and mortality.
- Trial name
- SSAIL (NCT02317549)
- Testing
- LB1148
- Where
- 34 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- Leading BioSciences, Inc
HIV Infections
A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs
The purpose of this study is to see if certain vitamins (C, E, B1, and B2) can keep lactate levels from becoming too high in patients who are taking nucleoside reverse transcriptase inhibitor (NRTI) anti-HIV drugs.
- Trial name
- NCT00037063
- Testing
- Thiamine hydrochloride, Riboflavin, Ascorbic acid
- Where
- 4 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Performance Enhancing Product Use, Change, Body Weight
Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International Athletes
This clinical study evaluates the acute effect of glycerol ingestion on performance (power output), weight, urine specific gravity, biochemical (antioxidants and lactate) and metabolic (indirect calorimetry) markers in…
- Conditions
- Performance Enhancing Product Use, Change, Body Weight, Change, Body Temperature, Antioxidative Stress
- Trial name
- NCT05295836
- Testing
- GLYCEROL
- Where
- Spain
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Exercise Training, BDNF
Effects of Different Types of Exercise on BDNF and Cognitive Performance (Exercise-BDNF)
Purpose The purpose of this study is to determine the acute effects of different exercise intensities (low, moderate, high) on brain-derived neurotrophic factor (BDNF) levels, trail making test performance, and perceived…
- Conditions
- Exercise Training, BDNF, Cognitive Functions, Lactate Blood Increase
- Trial name
- Exercise-BDNF (NCT07137611)
- Testing
- Low Exercise, Moderate-Intensity Exercise, HIIT Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Healthy, Lactate Blood Increase
The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain
The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
- Trial name
- NCT06665763
- Testing
- Sodium Lactate Solution
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Lactate Blood Increase, Fluid Overload
Goal-directed Fluid Therapy in Elderly Patients Undergoing Lumbar Surgery
This is a randomized controlled clinical trial which investigates whether goal directed fluid therapy( GDT ) would show the evidence of benefit from GDT in terms of lactate kinetics then may reduce postoperative complications in…
- Conditions
- Lactate Blood Increase, Fluid Overload, Postoperative Complications
- Trial name
- NCT03974906
- Testing
- Applying goal-directed fluid therapy by continuous hemodynamic monitoring system (LiDCO）
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
Hyperlactatemia, Healthy
The Role of Lactate in Lipolysis and Catabolism in Humans
Lactate may have anti-lipolytic effects when plasma concentrations of lactate reach levels similar to those seen during high intensity exercise.
- Conditions
- Hyperlactatemia, Healthy, Lactate
- Trial name
- LILACH (NCT04710875)
- Testing
- Na-lactate, Sodium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Lactate Blood Increase, Exhaustion - Physiological
Pilot Study to Examine the Acute Impact of Veillonella Supplementation on Exercise and Lactate Responses
The purpose of this study is to assess the health and performance outcomes associated with supplementation of Veillonella atypica.
- Trial name
- VP (NCT05816291)
- Testing
- Time to Exhaustion at velocity at VO2max
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Syncope, Lactate Blood Increase
Serum Lactate in Convulsive Syncopes Compared to Non-convulsive Syncopes
The investigators compared the serum lactate, serum prolactin and serum creatine kinase concentrations following convulsive and non-convulsive syncopes.
- Trial name
- NCT03062683
- Testing
- Lactate, prolactin and creatine kinase conc.
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Prostate Cancer, Surgery
Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic Prostaectomy
Fluid therapy during surgery is an important factor that is related to long term mortality and morbidity and it's directly related to tissue perfusion as well.
- Conditions
- Prostate Cancer, Surgery, Fluid Overload, Lactate Blood Increase
- Trial name
- NCT07626151
- Testing
- Liberal Fluid Therapy, Restricted Fluid Therapy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nazmy Edward Seif
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Hyperlactatemia, Cardiac Disease
Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation
The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.
- Conditions
- Hyperlactatemia, Cardiac Disease, Bypass Complication, Valve Disease, Heart
- Trial name
- NCT04046861
- Testing
- ascorbic acid,
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Maribor
Hyperglycemia, Metformin
Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery
Evaluation of the effect of peri-operative continuation of oral metformin therapy on the incidence of perioperative hyperglycemia compared to standard preoperative cessation of oral metformin therapy 24h before surgery.
- Conditions
- Hyperglycemia, Metformin, Type 2 Diabetes, Hyperlactatemia
- Trial name
- NCT04284722
- Testing
- Metformin Hydrochloride
- Volunteers
- 400 people
- Sponsor
- Kepler University Hospital
Tissue Hypoxia, Hyperlactatemia
Early Lactate-Directed Therapy in the Intensive Care Unit (ICU)
Blood lactate levels have long been related to tissue hypoxia, a severe condition in critically ill patients associated with the development of organ system failure and subsequent death.
- Trial name
- NCT00270673
- Testing
- Early lactate-directed therapy
- Where
- 5 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Erasmus Medical Center
HIV Infections, Insulin Resistance
Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine
The purpose of this study is to determine whether uridine supplementation will improve insulin sensitivity and overall carbohydrate metabolism in HIV-positive subjects who are currently undergoing treatment with antiretroviral…
- Conditions
- HIV Infections, Insulin Resistance, Hyperlactatemia
- Trial name
- NCT00471614
- Testing
- NucleomaxX (contains uridine)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Hyperlactatemia
Does Intravenous Lactated Ringer Solution Raise Measured Serum Lactate?
Lactated Ringer's (LR) solution bolus is commonly administered in the emergency department setting to seriously ill patients. It is also common to obtain blood samples to determine serum lactate levels to aid in the assessment of…
- Trial name
- NCT02950753
- Testing
- Lactated Ringer Solution, Normal Saline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center of Southern Nevada
Hyperlactacidemia
Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During Hepatectomy
A variety of reasons lead to a sharp increase in lactic acid levels in patients undergoing liver resection, while leading to hyperlactic acidemia, resulting in decreased cardiac output, elevated blood potassium, and response to…
- Trial name
- NCT04547296
- Testing
- Sodium Bicarbonate Ringer's Solution
- Where
- 7 sites in China
- Volunteers
- 484 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University