Clinical trials: Lactic Acid/Metabolism
Sepsis, Shock, Septic
Comparison of Peripheral Perfusion Indicators and Lactate Levels
In patients with septic shock undergoing intensive care unit monitoring, routine assessment of arterial and/or venous blood gas is conducted.
- Conditions
- Sepsis, Shock, Septic, Hypotensive, Lactate
- Trial name
- NCT06727318
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Gulhane Training and Research Hospital
Primary Prevention
Objective Physical Activity Assesment in Postmenopausal Women
The purpose of this study is to accurately assess weekly physical activity levels of postmenopausal women using lactate thresholds to individualize the accelerometer cut-points.
- Trial name
- NCT02984553
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centro de Estudios, Investigación y Medicina del Deporte
Metabolic Acidosis, Critical Illness
The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis
Background: The serum anion gap (AG) is commonly used as a screening tool for acid-base disorders. With modern laboratory techniques using ion-selective electrodes to measure the main electrolyte components of the AG, our…
- Conditions
- Metabolic Acidosis, Critical Illness, Anion Gap Acidosis, Lactic Acidosis
- Trial name
- NCT04975906
- Where
- Singapore
- Volunteers
- 16,475 people
- Sponsor
- Changi General Hospital
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)
The goal of this clinical trial is to evaluate the long-term safety and tolerability of zagociguat in patients with MELAS who completed study medication treatment in the lead-in study TIS6463-203.
- Trial name
- NCT06961344
- Testing
- zagociguat 15mg
- Where
- 16 sites in United States, Australia and 3 more
- Volunteers
- 37 people
- Sponsor
- Tisento Therapeutics
Metabolic Disturbance
Isothiocyanates and Metabolic Health
Many sprouts, for example broccoli sprouts, contain substances that have shown to have protective effects, both against oxidative stress and against carcinogenic substances.
- Trial name
- IMH (NCT05070585)
- Testing
- Isothiocyanate rich sprouts
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Renal Insufficiency, Chronic
Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study
To validate on the mid-term in moderate and severe renal failure (CKD 3-4) a nomogram to adapt a fixed metformin daily posology according to renal function on the basis of the first short-term study made by the investigators.
- Trial name
- METsuiviIRC (NCT02848508)
- Testing
- Metformin
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hypoxia, Lactic Acidosis
The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression
The purpose of this study is to analyze the gene expression patterns associated with various microenvironmental stresses in tumors to understand their roles in tumor progression and treatment responses.
- Trial name
- NCT00638040
- Where
- United States
- Sponsor
- Duke University
Hyperlactatemia, Cardiac Disease
Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation
The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.
- Conditions
- Hyperlactatemia, Cardiac Disease, Bypass Complication, Valve Disease, Heart
- Trial name
- NCT04046861
- Testing
- ascorbic acid,
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Maribor
Hyperlactatemia
Effect of Metformin on Lactate Metabolism
The main objective of this study is to evaluate the influence of metformin on lactate metabolism. The main outcome is the lactate production following an exogenous lactate overload in healthy male subjects without metformin and…
- Trial name
- NCT00390273
- Testing
- Metformin
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Energy Expenditure, Body Composition
The Energy Cost of 1-Hour Football Training
This study aims at investigating the energy expenditure following a single Football trainning session in middle aged males. The participants will perform a soccer training session [A single training session including 60 minutes…
- Conditions
- Energy Expenditure, Body Composition, Resting Metabolic Rate, Overweight and Obesity
- Trial name
- FAM (NCT06477705)
- Testing
- FAM
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
MELAS Syndrome
Glutamine Supplement in MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes) Syndrome
The purpose of this study is to assesses the efficacy of oral supplementation with glutamine over three months on several amino acids and lactate concentration measured in cerebrospinal fluid and cerebral lactate measured by…
- Trial name
- NCT04948138
- Testing
- Glutamine oral supplementation
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Jesús González de la Aleja Tejera
Shock, Hemorrhagic, Shock, Traumatic
Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients
MP4OX is a novel oxygen therapeutic agent specifically developed to perfuse and oxygenate tissue at risk for ischemia and hypoxia.
- Conditions
- Shock, Hemorrhagic, Shock, Traumatic, Acidosis, Lactic
- Trial name
- NCT01004198
- Testing
- MP4OX, Ringers Lactate solution
- Where
- 13 sites in France, Germany and 2 more
- Volunteers
- 51 people
- Sponsor
- Sangart
Diabetes, Obesity
PERFECT Project - Part 2 - Study 1
The objectives are to test the acute effects of different extruded pulse snacks on: 1) aerobic endurance and substrate oxidation during exercise 2) response of blood glucose, insulin and appetite on an aerobic exercise session…
- Trial name
- NCT02402517
- Testing
- Control, Small particle size pea flour, Large particle size pea flour
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Normal Anion Gap Metabolic Acidosis
Ringer's Lactate Versus Normal Saline in Caesarean Section
The objective of this study is to compare the effect on mean maternal and neonatal pH, and 24-hour postoperative morbidity, following intraoperative infusion of Ringer's Lactated versus normal saline in caesarean section at…
- Trial name
- NCT01585740
- Testing
- 0.9% Normal Saline, Ringer's Lactate
- Where
- Uganda
- Volunteers
- 500 people
- Sponsor
- Makerere University
Lactate Blood Increase, Exhaustion - Physiological
Pilot Study to Examine the Acute Impact of Veillonella Supplementation on Exercise and Lactate Responses
The purpose of this study is to assess the health and performance outcomes associated with supplementation of Veillonella atypica.
- Trial name
- VP (NCT05816291)
- Testing
- Time to Exhaustion at velocity at VO2max
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Diabetic Ketoacidosis
Intravenous Fluids in Adults With Diabetic Ketoacidosis in the Emergency Department
Diabetes mellitus is a common chronic disease. It is estimated that up to 40% of adults may develop diabetes in their lifetime. Patients with poorly controlled blood sugars often visit the emergency department for treatment of…
- Trial name
- BRISK-ED (NCT04926740)
- Testing
- Ringer's lactate
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Glycogen Storage Disease Type IA, Glycogen Storage Disease Type I
Accuracy of Home Lactate Meter and Accu-chek Glucometer in Patients With Glycogen Storage Disease
The goal of this study is to determine if the Lactate Plus meter is accurate compared to lab lactate levels, and to determine if the Accu chek guide glucometer is accurate compared to lab serum glucose levels in patients with…
- Conditions
- Glycogen Storage Disease Type IA, Glycogen Storage Disease Type I, Glycogen Storage Disease Type IB, Glycogen Storage Disease Xi
- Trial name
- NCT07459582
- Testing
- Lactate Meter, Accu Chek
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Connecticut Children's Medical Center
Donor Hepatectomy, Serum Lactate
Effect of Preoperative Carbohydrate Loading on Serum Lactate Levels in Patients Undergoing Donor Hepatectomy
This randomized controlled trial investigated whether preoperative carbohydrate loading reduces perioperative serum lactate levels in patients undergoing donor hepatectomy.
- Conditions
- Donor Hepatectomy, Serum Lactate, Preoperative Carbohydrate Loading
- Trial name
- NCT07723391
- Testing
- Preoperative Carbohydrate Loading
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shifa International Hospital
Cardiopulmonary Bypass
Comparative Analysis Between Ringer's Lactate vs Plasma Lyte-A as Cardiopulmonary Bypass Prime
Metabolic acidosis is a frequent problem in cardiopulmonary bypass. The cause is poorly understood, but it appears to be multifactorial. It is assumed to be result of hypoperfusion with resultant lactatemia.
- Trial name
- NCT03043131
- Testing
- Plasmalyte A, Ringer Lactate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pre Diabetes, Metabolic Syndrome
Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?
Aim To investigate the effects of oral lactate administration on nutrient absorption and substrate utilization in individuals with pre-diabetes.
- Trial name
- NCT06668714
- Testing
- Lactate + mixed meal, PET-scan, Mixed meal with 18F-FTHA
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Aarhus