Clinical trials: Lactic Acidosis
MELAS Syndrome
Glutamine Supplement in MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes) Syndrome
The purpose of this study is to assesses the efficacy of oral supplementation with glutamine over three months on several amino acids and lactate concentration measured in cerebrospinal fluid and cerebral lactate measured by…
- Trial name
- NCT04948138
- Testing
- Glutamine oral supplementation
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Jesús González de la Aleja Tejera
Compare Blood Age for Transfusion
Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital
In resolving lactic acidosis among children with severe malarial anemia, there is no difference between those transfused with blood of longer storage compared to shorter storage age
- Trial name
- NCT01580111
- Testing
- Blood transfusion
- Where
- Uganda
- Volunteers
- 74 people
- Sponsor
- Makerere University
Lactic Acidosis
Remote Ischemic Preconditioning During Cardiopulmonary Bypass
The objective of study is to detect effect of remote ischemic preconditioning on serum lactate levels during and after cardiac surgery with cardiopulmonary bypass in addition to its effect on cardiac and renal clinical outcomes.
- Trial name
- RIPC (NCT03723993)
- Testing
- Inflated cuff, Non inflated cuff
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fayoum University
Mitochondrial Enzyme Deficiencies
Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access
Expanded access to DCA as continued treatment for congenital lactic acidosis.
- Trial name
- CLA (NCT01797276)
- Testing
- Dichloroacetate
- Where
- United States
- Sponsor
- University of Florida
Lactic Acidosis
Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis
OBJECTIVES: I. Compare the safety of sodium dichloroacetate (DCA) vs placebo in children with congenital lactic acidosis. II. Determine the quality of life of these patients. III.
- Trial name
- NCT00004490
- Testing
- sodium dichloroacetate
- Volunteers
- 45 people
- Sponsor
- University of Florida
Renal Insufficiency, Chronic
Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study
To validate on the mid-term in moderate and severe renal failure (CKD 3-4) a nomogram to adapt a fixed metformin daily posology according to renal function on the basis of the first short-term study made by the investigators.
- Trial name
- METsuiviIRC (NCT02848508)
- Testing
- Metformin
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Drug Overdose, Metformin
Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both…
- Conditions
- Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis
- Trial name
- NCT07193069
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Type 2 Diabetes Mellitus
Metformin Treatment, Renal Function and Lactic Acidosis
From a central registry at the National Board of Health and Welfare in Sweden collect all patients in the city of Malmö prescribed metformin during two years.
- Trial name
- NCT01358994
- Where
- Sweden
- Volunteers
- 4,500 people
- Sponsor
- Skane University Hospital
Type 2 Diabetes
Lactic Acidosis and Prior Metformin Treatment
Metformin is a drug frequently prescribed to patients with type 2 diabetes. Furthermore, diabetes can lead to micro- and macrovascular complications that may cause chronic organ failure.
- Trial name
- MALA (NCT07300293)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Diabetes Mellitus, Lactic Acidosis
Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
The purpose of this study is to determine whether metformin causes lactic acidosis in diabetic patients with preserved kidney function, undergoing coronary angiography or angioplasty with new contrast media.
- Trial name
- NCT01873859
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 166 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Trauma, Hemorrhagic Shock
Phase 2c Dose Comparison Study of MP4OX in Trauma
MP4OX is being developed as an ischemic rescue therapy to perfuse and oxygenate tissues at risk during hemorrhagic shock. MP4OX is a pegylated hemoglobin-based colloid designed to improve perfusion and target delivery of oxygen…
- Conditions
- Trauma, Hemorrhagic Shock, Lactic Acidosis
- Trial name
- NCT01973504
- Testing
- MP4OX, Control
- Where
- 31 sites in Australia, Belgium and 9 more
- Sponsor
- Sangart
Lactic Acidosis
Dichloroacetate Kinetics, Metabolism and Toxicology
Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern.
- Trial name
- NCT00015015
- Testing
- Dichloroacetate
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Epilepsy
Lactic Acidosis During and After Seizures
This project looks at the time course of lactic acid rise (if any) after seizures. Salivary and capillary lactic acid are tested. This type of measurement may be useful in signalling the occurrence or recent history of a seizure.
- Trial name
- NCT01833247
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Liver Transplantation
Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation
Lactic acidosis is a common phenomenon occurring during orthotopic liver transplantation (OLT), especially during the anhepatic and early postreperfusion phases.
- Trial name
- GIK (NCT03522181)
- Testing
- saline, Insulin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Central South University
Heart Failure, Acidosis, Lactic
Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery
The objective of this study is to determine whether preoperative parenteral thiamin supplementation does prevent the intra and early postoperative increase of lactate and whether this effect is related to the extent of thiamine…
- Conditions
- Heart Failure, Acidosis, Lactic, Thiamine Deficiency
- Trial name
- NCT01524315
- Testing
- Vitamin B1-ratiopharm
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Hemodynamics, Renal Dialysis
Presep and Vascath Interaction Study
This is a prospective, observational study to compare presep(tm) catheter central vein mixed venous oxygen saturation before and after dialysis is initiated via the vascath(tm) central venous dialysis catheter to evaluate device…
- Conditions
- Hemodynamics, Renal Dialysis, Sepsis, Shock
- Trial name
- NCT00739089
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Mitochondrial Myopathy, MELAS Syndrome
Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia
OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia. II. Define the nature of the metabolic defect.
- Conditions
- Mitochondrial Myopathy, MELAS Syndrome, Lactic Acidosis
- Trial name
- NCT00004353
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Center for Research Resources (NCRR)
Shock, Hemorrhagic, Shock, Traumatic
Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients
MP4OX is a novel oxygen therapeutic agent specifically developed to perfuse and oxygenate tissue at risk for ischemia and hypoxia.
- Conditions
- Shock, Hemorrhagic, Shock, Traumatic, Acidosis, Lactic
- Trial name
- NCT01004198
- Testing
- MP4OX, Ringers Lactate solution
- Where
- 13 sites in France, Germany and 2 more
- Volunteers
- 51 people
- Sponsor
- Sangart
Plasmodium Falciparum Malaria
The Cytoadherence in Pediatric Malaria (CPM) Study
The purpose of this study is to determine the importance of key blood group molecules in the clinical outcome of Plasmodium falciparum malaria infection in children.
- Trial name
- CPM (NCT00707200)
- Where
- Uganda
- Volunteers
- 2,000 people
- Sponsor
- University Health Network, Toronto
Lactic Acidosis, Metformin
Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis
Metformin is the first line drug of choice for the treatment of type II diabetes. Lactic acidosis can develop as a side effect, especially when renal failure leads to drug accumulation.
- Trial name
- NCT00942123
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico