Clinical trials: Lactobacillus Infection
Enterocolitis, Pseudomembranous Colitis
Addition of Lactobacillus to Metronidazole in Treatment of CDAD
The purpose of this study is to determine whether dietary supplementation with Lactobacillus GG will reduce the rate of failure or relapse following treatment of CDAD with metronidazole.
- Conditions
- Enterocolitis, Pseudomembranous Colitis, Antibiotic-associated Colitis
- Trial name
- NCT00304863
- Testing
- Lactobacillus GG
- Where
- United States
- Sponsor
- Michael E. DeBakey VA Medical Center
Nosocomial Infection, Necrotizing Enterocolitis
Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants
The purpose of this study is to determine whether oral probiotic supplementation could reduce the incidence of nosocomial infections in preterm infants.
- Trial name
- NCT01340469
- Testing
- probiotics
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Bacterial Vaginosis (BV), Recurrent Bacterial Vaginosis
Evaluation of the Medical Device Vagitab - T as Adjuvant Therapy in Patients With Bacterial Vaginosis.
This clinical trial is looking at how well and safely the vaginal administration of Vagitab-T works . Vagitab-T is already on the market in several countries in Europe as a medical device.
- Trial name
- Vagitab (NCT06725888)
- Testing
- Vagitab -T vaginal tablets. Components: tyndallized probiotic L. plantarum HA-119, lactic acid, and xylo-oligosaccharides, lauryl glucoside, and macrogol 3350:
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- S.I.I.T. Srl
Pulmonary Inflammation, Cystic Fibrosis
Modulation of Intestinal and Pulmonary Inflammation by Lactobacillus Diet Supplementation in Pediatric Cystic Fibrosis
Pulmonary inflammation is an independent risk factor for disease progression in cystic fibrosis patients (CF). Yet, no effective treatment is known to reduce this detrimental inflammation.
- Conditions
- Pulmonary Inflammation, Cystic Fibrosis, Microbiota
- Trial name
- MoHuM-1 (NCT01837355)
- Testing
- Lactobacillus rhamnosus
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Helicobacter Pylori Infection
Eradication of Helicobacter Pylori With a Lactobacillus Reuteri Strain Plus Proton Pump Inhibitor
Meta-analyses involving >4000 subjects with probiotics added to antimicrobial Helicobacter pylori eradication therapy in populations with antibiotic resistance have reported a mean increase in eradication rate of 12.2%.
- Trial name
- NCT03404440
- Testing
- L.Reuteri
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Bari
Death, Nosocomial Infection
Prophylactic Probiotics in Premature Infants
This study tries to determine whether the oral administration of a specific probiotic (good bacteria) in premature infants hospitalized in a neonatal intensive care unit may prevent infections and the development of a severe…
- Trial name
- C3P (NCT00727363)
- Testing
- Lactobacillus reuteri
- Where
- 8 sites in Colombia
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- Colombian Neonatal Research Network
Helicobacter Pylori Infection
Control of Helicobacter Pylori Infection by Probiotics
Helicobacter pylori colonises an estimated 50% of the world´s population (Taylor \& Blaser, 1991; Go, 2002). Despite clear clinical guidelines on the treatment of this infection (Malfertheiner et al.
- Trial name
- NCT01115296
- Testing
- L. reuteri DSM 17938 and ATCC PTA 6475
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bari
Common Infectious Diseases
Effect of the Consumption of a Fermented Milk on Common Infections in Children Aged 3-6 Years, Attending Day Care Centers
This multicentric, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Trial name
- NCT01200173
- Testing
- 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), 2-Non fermented dairy product (control)
- Where
- Russia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Microbial Colonization
Investigating the Impact of Humiome B2 (Colon Delivered Riboflavin) and Riboflavin-overproducer Probiotic Strain Limosilactobacillus Reuteri AMBV339 on Intestinal and Vaginal Microbiome and Health of Healthy Adult Women (The VIAB2L Project)
The goal of this clinical trial is to learn if the probiotic strain Limosilactobacillus reuteri AMBV339 or colon-delivered riboflavin or their combination can change the gut and vaginal microbiome and metabolomics.
- Trial name
- VIAB2L (NCT06425081)
- Testing
- Limosilactobacillus reuteri AMBV339, Humiome B2, Limosilactobacillus reuteri AMBV339 + Humiome B2
- Where
- Belgium
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Helicobacter Pylori Infection
IMPROVEMENT in ERADICATION of H-PYLORI INFECTION
Efficacy in terms of H pylori eradication of clarithromycin based sequential therapy with lactobacillus is better than sequential based therapy alone.
- Trial name
- NCT05701683
- Testing
- Lactobacillus Reuteri Probiotic
- Where
- Pakistan
- Volunteers
- 195 people
- Sponsor
- Liaquat National Hospital & Medical College
Herpes Labialis
Immune Evidence to the Consumption of Lactobacillus GG and FOS Consumption in Patients With Herpes Labialis
Herpes labialis (HL) is the result of the presence of a virus called HSV-1 and is a common disease. Because of its visibility due to cold sores it has a serious impact on social life.
- Trial name
- EVIM2 (NCT03310294)
- Testing
- Prebiotics and Probiotics
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Sprim Advanced Life Sciences
Orthodontic Appliance Complication, Lactobacillus Infection
SPACE MAINTAINERS EFFECTS ON ORAL MİCROFLORA
Space maintainers are used to preserve the space after premature loss of teeth but they could effect some factors that play a role in caries formation.
- Conditions
- Orthodontic Appliance Complication, Lactobacillus Infection, Dental Caries in Children, Streptococcus, Other Specified Group
- Trial name
- NCT04749654
- Testing
- The Salivary pH measured, The saliva flow rate was measured, Streptococcus mutans and Lactobacillus counts in saliva were measured
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Helicobacter Pylori Infection
Study of the Usefulness of the Probiotic 'Lactobacillus Reuteri' in the Therapy of Quadruple Eradication of Helicobacter Pylori Infection in Usual Clinical Practice.
Helicobacter pylori is a Gram-negative bacterium with a helical bacillus shape that it's able to penetrate and colonize the stomach mucosal lining by infecting it. The eradication treatment of H.
- Trial name
- NCT03150394
- Testing
- GASTRUS
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Dr. Luis Fernandez
Intestinal Infections, Dysbacteriosis
Study of the Safety and Tolerability of the Broad-spectrum Probiotic Medicine "AS-Probionorm"
The subject of this clinical trial is the medicine "AS-Probionorm". Pharmacological group - Antidiarrheal drugs. Antidiarrheal microorganisms. Microorganisms that produce lactic acid.
- Trial name
- NCT06252831
- Testing
- "AS-Probionorm"
- Where
- Kazakhstan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Industrial Microbiology LLP
Bacterial Vaginosis
Will Lactobacillus Increase Cure Rate After Treatment of Bacterial Vaginosis and Chronic Vulvovaginal Candida
From the earlier studies the investigators have treated women with bacterial vaginosis and cronic vulvovaginal candida. The investigators have then treated them with laktobacilli 10 days for 2 month.
- Trial name
- NCT02295579
- Testing
- lactobacillus (EcoVag)
- Where
- 2 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Skaraborg Hospital
Human Papillomavirus Infection
Probiotc Lactobacillus Crispatus-M247 (Crispact®) Supplementation in the Sterilization of High-risk Human Papilloma (HPV-HR) Viruses
There is growing scientific interest in probiotic supplementation as a possible therapy for clearing the human papillomavirus (HPV) infection and reducing the risk of developement of cervical cancer.
- Trial name
- NCT06245486
- Testing
- Crispact®
- Volunteers
- 150 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Recurrent Vulvovaginal Candidiasis
Effect of a Lactobacillus Strain on the Prevention of Recurrent Vaginal Candidiasis
The objective of this study is to evaluate the efficacy of the consumption of the one probiotic strain in the prevention of new vaginal candidiasis events in women with recurrent vaginal candidiasis.
- Trial name
- NCT04639544
- Testing
- Lactobacillus strain
- Where
- Spain
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Healthy Infants
Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants
Randomized, doble blind, clinical, controlled trial aimed to investigate the role of Lactobacillus reuteri DSM 17938 in the prevention of gastrointestinal and respiratory tract infections in mexican children who attend day care…
- Trial name
- NCT01249911
- Testing
- Lreuteri
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- National Institute of Pediatrics, Mexico
Post-COVID-19 Syndrome
Efficacy of Lactobacillus Paracasei PS23 for Patients With Post-COVID-19 Syndrome
To evaluate whether probiotics PS23 can improve the symptoms of patients with long COVID-19 ; also to evaluate the effects on blood cortisol and inflammation-related indicators in patients.
- Trial name
- NCT05813899
- Testing
- PS23 heat-treated
- Where
- Taiwan
- Volunteers
- 39 people
- Sponsor
- Mackay Memorial Hospital
Bacterial Vaginosis (BV)
Live Double Combined Lactobacillus Capsule for Vaginal Use（IIa）
This is a mutilcenter, randomized, double-blind, Metronidazole controlled phase lIa clinical study to evaluate the safety and tolerability of dual - live lactobacilli-containing vaginal capsules for the treatment of Bacterial…
- Trial name
- BV (NCT07418996)
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guangdong Longchuangji Pharmaceutical Co., Ltd.