Clinical trials: Language Disorder, open to volunteers
Aphasia
Neural Bases of Vocal Sensorimotor Impairment in Aphasia
Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control.
- Trial name
- NCT04742894
- Testing
- Visual Feedback Training
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Autism Disorder, Language Development Disorders
Rural Autistic Individuals - Supporting Expression
This research study investigates how hand gestures can support language comprehension and communication skills of hearing speaking, non-speaking, and/or minimally verbal individuals with Autism Spectrum Disorders (ASD), who are…
- Conditions
- Autism Disorder, Language Development Disorders, ADHD, Typical Development
- Trial name
- RAISE (NCT07054866)
- Testing
- Speech-Gesture combinations
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montana State University
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Psychotic Disorder
Speech-based Assessment of Relapse Risk in People With Psychosis
This observational, multinational study assesses the feasibility of speech and self-report data collection across six languages for Artificial Intelligence (AI)-driven relapse risk estimation in psychosis.
- Trial name
- TRUSTING-WP4 (NCT07397975)
- Testing
- Weekly online speech assessments via a smartphone app collect speech and self-report data. Recordings are securely transferred and analyzed by an AI-based backend to calculate relapse risk scores.
- Where
- 7 sites in Czechia, Ireland and 4 more
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Philipp Homan
Logopenic Progressive Aphasia, Primary Progressive Aphasia
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
AD afflicts over 5.5. million Americans and is one of the most expensive diseases worldwide. In AD the variant in which language functions are most affected are referred to as 'logopenic variant Primary Progressive Aphasia'…
- Trial name
- NCT03887481
- Testing
- High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Stuttering, Childhood, Stuttering
Network Connectivity and Temporal Processing in Adolescents Who Stutter
The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter.
- Trial name
- NCT05286151
- Testing
- Rhythm discrimination
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Smartphone AI Assistance for Prehospital ECG Interpretation
Prehospital providers interpret 12-lead electrocardiograms (ECGs) under time pressure and without immediate expert support. Missed acute coronary occlusion - occlusion myocardial infarction (OMI) - delays reperfusion, while false…
- Conditions
- Acute Coronary Syndromes, ST Elevation Myocardial Infarction, Non-ST Elevated Myocardial Infarction, Myocardial Infarction (MI)
- Trial name
- ECG-IA (NCT07810686)
- Testing
- Smartphone large language model assistance (GPT-4o, version-locked)
- Where
- Switzerland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care
Aphasia
Based on the Spatio-temporal Coding Characteristics of Frontotemporal Network, This Paper Explores the Mechanism of Five-tone Speech Training in Reshaping Language Fluency Function.
To explore the mechanism of five-tone speech training in reshaping language fluency function and the clinical efficacy of aphasia language function, daily communication ability and communication efficiency based on the temporal…
- Trial name
- NCT07329751
- Testing
- Traditional Chinese Medicine Five-Tone Therapy, Melodic Intonation Training, Standard speech therapy; Routine medical treatment; Health education
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fujian University of Traditional Chinese Medicine
Autism Spectrum Disorder
Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Researchers think brain development may be controlled by gamma-aminobutyric acid (GABA).
- Trial name
- NCT04798274
- Testing
- Continuous Theta Burst Stimulation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
AI-Assisted Diagnosis, Large Language Models
Improving AI-Assisted Medical Diagnosis and Triage by the General Public
This study is a randomized controlled trial (RCT) investigating whether access to a new LLM interface can improve medical triage and diagnostic accuracy for laypeople compared to access to a standard LLM interface.
- Trial name
- NCT07728513
- Testing
- new GPT-4o Interface, Control
- Where
- Pakistan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Preterm Birth, Developmental Dyslexia
Reading-FREE Markers for Early Detection of Developmental Dyslexia
This study aims to identify early signs of developmental dyslexia (DD) and other reading difficulties in children born preterm, using behavioral, cognitive, and brain imaging data collected before reading problems typically…
- Trial name
- FREE-DD (NCT07072104)
- Testing
- Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 2, MRI - Grade 2, Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 3
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Dyslexia, Developmental, Reading
Enhancing Letter-Speech Sound Learning and Reading Network Activation With Transcranial Electrical Stimulation
This study investigates the effects of transcranial electrical stimulation (tES) on the brain and its potential to enhance reading-related learning.
- Conditions
- Dyslexia, Developmental, Reading, Dyslexia, Learning
- Trial name
- LexiStim (NCT07546292)
- Testing
- Transcranial random noise stimulation
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Silvia Brem
Wisconsin Alzheimer's Disease Research Center, Wisconsin Registry for Alzheimer's Prevention
Speech Pattern Evaluation and Analysis for Knowledge of AD
The goal of this observational study is to validate changes in speech as a measure of cognition in individuals at increased risk of Alzheimer's disease and related dementias (ADRD).
- Trial name
- SPEAK-AD (NCT06230783)
- Testing
- TalkTracker
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer's Disease (AD), Frontotemporal Dementia (FTD)
Automated Language Analysis in Neurodegenerative Diseases: Application of Artificial Intelligence Models
This multicenter study aims to characterize the language profiles of patients with various neurodegenerative diseases, including Alzheimer's disease (AD), Primary Progressive Aphasia (PPA), behavioral variant Frontotemporal…
- Conditions
- Alzheimer's Disease (AD), Frontotemporal Dementia (FTD), Parkinsons Disease (PD), Lewy Body Dementia
- Trial name
- AILAN (NCT07906769)
- Testing
- Speech and language Test to support clinical diagnosis
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Ophthalmology, Large Language Models
A Multimodal AI Agent for Ophthalmic Clinical Decision Support
This study is a multicenter randomized controlled trial evaluating the effectiveness and safety of EyeAgent, a multimodal artificial intelligence (AI) agent designed to assist ophthalmologists in clinical decision-making.
- Conditions
- Ophthalmology, Large Language Models, AI Agent, Eye Disease
- Trial name
- NCT07401459
- Testing
- EyeAgent AI system
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Ophthalmic Diseases (Specific Types Not Restricted)
Research on the Real-World Community Application of Large Language Models
There is an imbalance between the supply and demand of eye care services, especially in local communities and remote areas. To address this, it's important to use new intelligent technologies to expand the reach of eye disease…
- Trial name
- NCT06966882
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Autism, Autism Spectrum Disorder
Milieu Teaching-AV: Adaptation of Milieu Teaching That Encourages Looking to the Mouth
This project will look at Milieu Teaching (i.e., a language intervention) that encourages looking to audiovisual speech cues (Milieu Teaching-AV) for infants with autistic older siblings (Baby Sibs), who are highly likely be…
- Conditions
- Autism, Autism Spectrum Disorder, Autism, Susceptibility to, 6
- Trial name
- MilieuTeach-AV (NCT07494513)
- Testing
- Milieu Teaching-AV, Milieu Teaching-NoAV
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Developmental Language Disorder, Language Impairment
The Relationship Between Child Language Proficiency and Language of Treatment on the Outcomes of Bilingual Children with Developmental Language Disorder
Of the 12 million children in the USA growing up bilingual, about 1 million experience Developmental Language Disorder (DLD), a disorder in language learning and use.
- Trial name
- NCT06085300
- Testing
- Sentence recast
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Houston
Schizophrenia Disorders, Psychosis
Magnetoencephalography in Psychosis Program
This research involves the examination of speech, thinking patterns and symptoms and recordings from brain's activity in patients with schizophrenia.
- Trial name
- MEGPSY (NCT06978881)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke
RCT of HeartBot in Women
The goal of this clinical trial is to find out whether an app-based program called HeartBot II, which uses an artificial intelligence (AI) chatbot, can help improve women's awareness and knowledge of heart attacks in women.
- Conditions
- Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke, Participants Should Have no Terminal Illness or Diagnosed Cognitive Impairment, Including Alzheimer's Disease, Participants Should Not be a Healthcare Professionals or Healthcare Trainees
- Trial name
- HeartBot II (NCT07416734)
- Testing
- HeartBot II Program, Waitlist Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco