Clinical trials: Language Disorder
Primary Progressive Aphasia, Apraxia of Speech
Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area and left inferior frontal gyrus)…
- Trial name
- NCT05368350
- Testing
- high-definition transcranial direct current stimulation (HD-tDCS)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas at Dallas
Aphasia, Stroke
The Intensive Comprehensive Aphasia Program (ICAP)
The purpose of this study is to conduct a randomized clinical trial that assesses the efficacy and cost-effectiveness of an Intensive Comprehensive Aphasia Program (ICAP), specifically focusing on the variable of intensity.
- Trial name
- NCT03514186
- Testing
- Speech and Language Therapy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia, Stroke
Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia
The purpose of this study is to assess changes in language abilities of participants with chronic, post-stroke aphasia following an 8-week therapy period combined with brain stimulation.
- Trial name
- NCT04142866
- Testing
- Anodal transcranial direct current stimulation, Speech-Language Therapy (SLT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- City University of New York
Deafness, Hearing Loss
Family ASL: Longitudinal Study of Deaf Children and Hearing Parents Who Receive Services to Support the Learning of ASL
This study examines the development of American Sign Language by deaf and hard of hearing (DHH) children and their parents.
- Trial name
- FASL (NCT04988451)
- Testing
- ASL Services
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Connecticut
Lung Cancer, Gastrointestinal Cancer
ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy
Evaluate the feasibility of using a chatbot combined with continuous activity monitoring to proactively identify, appropriately triage and help manage patients' symptoms during cancer treatment Determine whether such an early…
- Conditions
- Lung Cancer, Gastrointestinal Cancer, Head and Neck Cancer
- Trial name
- NCT05318027
- Testing
- ChatBot
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Auditory Perceptual Disorder, Language Delay
Hereditary Deficits in Auditory Processing Leading to Language Impairment
Some children with certain language disorders may not properly process the sounds they hear, resulting in language impairments. The purpose of this study is to determine if deficits in auditory temporal processing the way the…
- Conditions
- Auditory Perceptual Disorder, Language Delay, Language Disorder
- Trial name
- NCT00004570
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Dyslexia, Dance Therapy
The Effects of Creative Dance Therapy on Motor and Executive Functions in Children With Dyslexia
Although some benefits of dance have been described for motor and cognitive skills, the effects on individuals with dyslexia are unclear.
- Conditions
- Dyslexia, Dance Therapy, Motor Skills, Executive Function
- Trial name
- NCT05850169
- Testing
- Creative Dance Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Ankara Medipol University
Aphasia, Dysgraphia
Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery
The purpose of this study is to investigate the effects of treatment for specific language deficits in people with aphasia. In addition to language and cognitive measures, changes in brain function will also be gathered before…
- Conditions
- Aphasia, Dysgraphia, Anomia, Agrammatism
- Trial name
- NCT01927302
- Testing
- Treatment Focusing on Naming Objects, Treatment Focusing on Improving Spelling Abilities, Treatment Focusing on Improving Sentence Processing
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Bipolar Disorder, Schizophrenia
Emotions in Schizophrenia and Bipolar Disorders: a Common Vulnerability?
The initial aim of the project was to gain an understanding of the comprehension of "language-oriented" emotions among schizophrenic and bipolar patients.
- Trial name
- ELISE (NCT02805088)
- Testing
- Electroencephalographic recordings, neuropsychological evaluation, clinical evaluation of symptoms
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Type 2 Diabetes Mellitus (DM)
Proteome-Wide Association and LLM-Based Prioritization of Type 2 Diabetes Protein Targets
Type 2 diabetes is a common condition in which the body has difficulty controlling blood sugar. This study will use existing genetic, protein, and health data from prior research studies to identify blood proteins that may play a…
- Trial name
- LAUNCH-T2D (NCT07832656)
- Volunteers
- 31,994 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Brain Neoplasms
Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques
One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk.
- Trial name
- MALTA (NCT01793714)
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Epilepsy
Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy: A Case Study
Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure.
- Trial name
- REPREO SCED (NCT05325047)
- Testing
- Intensive speech rehabilitation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Aphasia, Stroke
Intention Treatment for Anomia
Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia).
- Trial name
- NCT04267198
- Testing
- Intention Treatment for Anomia
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development
Breast Neoplasms, Breast Diseases
Construction of a Benchmark for Breast Ultrasound AI Interpretation and Performance Evaluation of Multimodal AI Models
This single-center, retrospective, observational study aims to construct a standardized benchmark evaluation system for intelligent breast ultrasound image interpretation and to systematically assess the diagnostic performance of…
- Conditions
- Breast Neoplasms, Breast Diseases, Ultrasonography
- Trial name
- BUST-AI Bench (NCT07500428)
- Testing
- Multimodal AI Model Diagnostic Evaluation
- Where
- China
- Volunteers
- 1,380 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Developmental Language Disorder, Adults Without Language Disorder
Category Learning Retention in Adults With and Without Developmental Language Disorder
Approximately 7% of the population experiences developmental language disorder (DLD), a language disorder with unclear causes. DLD affects communication beyond adolescence and poses challenges for education and career advancement…
- Trial name
- Time2Learn (NCT05901493)
- Testing
- Perceptual category training
- Where
- 2 sites in United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Stuttering, Adult
Investigating the SMA's Role in Speech and Reading Fluency in PWS With rTMS
The goal of this clinical trial is to study how a part of the brain called the supplementary motor area (SMA) is connected to speech and reading fluency in adults who stutter.
- Trial name
- NCT06809387
- Testing
- Brain stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Medipol University
Brain Arteriovenous Malformations
Language Function Reorganization in Patients With Arteriovenous Malformations
Brain arteriovenous malformation (AVM) is generally considered as a congenital lesion. Its unique clinical manifestation is that when the unruptured AVM involves and destroys the language function area of the left hemisphere, the…
- Trial name
- NCT07537504
- Testing
- MRI
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Aphasia
Semantic Feature Analysis Treatment for Aphasia
This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of…
- Trial name
- NCT04215952
- Testing
- Semantic Feature Analysis Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Pittsburgh Healthcare System
Diabetes
SUPREME-DM (Diabetes Mellitis) Treatment Study
This multisite pragmatic clinical trial was designed to assess the effectiveness of a single scripted telephone call to diabetes patients who (a) were currently above recommended clinical goals for glucose, blood pressure, or…
- Trial name
- NCT02192255
- Testing
- Intervention Phone Call
- Where
- United States
- Volunteers
- 2,378 people
- Sponsor
- HealthPartners Institute
Central Nervous System Disease, Cerebrovascular Accident
Brain Processing of Language Meanings
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible.
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury
- Trial name
- NCT00005004
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)