Clinical trials: Language Impairment
Stroke
Speech Therapy for Aphasia: Comparing Two Treatments
This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking.
- Trial name
- PMvSFA (NCT02153710)
- Testing
- Semantic Feature Analysis therapy, Phonomotor Therapy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Primary Progressive Aphasia
Transmagnetic Stimulation Pilot in Primary Progressive Aphasia
Frontotemporal degeneration (FTD) is a non-Alzheimer's dementia that is the 2nd most common cause of dementia in the United States.
- Trial name
- TMS in PPA (NCT05860647)
- Testing
- Intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- HealthPartners Institute
Alzheimer's Disease, Aphasia
Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease
The investigators wish to investigate the efficacy of targeted repetitive transcranial magnetic stimulation (rTMS) on expressive language in patients with Alzheimer's disease (AD).
- Conditions
- Alzheimer's Disease, Aphasia, Dementia
- Trial name
- NCT00814697
- Testing
- Repetitive Transcranial Magnetic Coil Stimulation (rTMS)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The New York Memory Services
Aphasia, Cerebrovascular Stroke
Transcranial Magnetic Stimulation to Improve Speech in Aphasia
The purpose of this study is to examine whether repetitive transcranial magnetic stimulation (rTMS) can be used to improve speech in chronic stroke patients with aphasia. Aphasia patients can have problems with speech production.
- Trial name
- NCT00608582
- Testing
- Transcranial Magnetic Stimulation, Repetitive
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- Boston University
Language Development Disorders, Speech Sound Disorder
Manipulating Linguistic Complexity to Improve Child Language Treatment Outcomes
Phonological disorder (PD) and specific language impairment (SLI) directly impact a child's ability to communicate and are among the most prevalent developmental disorders.
- Trial name
- NCT03977701
- Testing
- Phonological treatment, Morpheme treatment
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- San Diego State University
Developmental Language Disorder, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder, Specific Language Impairment, Language Development
- Trial name
- NCT06026124
- Testing
- Retrieval-based word learning: Repeated Spaced Retrieval condition, Retrieval-based word learning: Repeated Study condition
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Purdue University
Aphasia, Cerebrovascular Accident
Treating Intention In Aphasia: Neuroplastic Substrates
The purpose of this study is to determine if an "intentional act" improves treatment response for patients with nonfluent aphasia. The treatment involves naming pictures and saying members of categories.
- Trial name
- NCT00567242
- Testing
- Word-finding with intention component, Word-finding with no intention component
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Language Disorder
Efficacy of AMALS in Treating Language Impairment in Children
The goal of this proposal is to examine the efficacy of a manualized treatment intervention, AMALS: Addressing Multiple Aspects of Language Simultaneously, which is designed to remediate semantic, morphological, and syntactic…
- Trial name
- AMALS (NCT00840060)
- Testing
- AMALS, DTA
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Lamar University
Parkinson's Disease
An RCT of a Telemedicine Intervention for Hypokinetic Dysarthria in PD
Nearly 90% of people with Parkinson's disease have speech and voice disorders that negatively impact their ability to communicate effectively in daily life.
- Trial name
- NCT04617496
- Testing
- Combined speech and exercise intervention, Health education
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- VA Office of Research and Development
Aphasia
Transcranial Direct Current Stimulation (tDCS) and Intensive Therapy in Aphasia
Intensive therapy for aphasia has been demonstrated to improve language functioning after stroke or other neurological injury. However, recovery is generally not complete and new therapies are needed to improve outcomes.
- Trial name
- NCT03510182
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Michigan
Selective Mutism
What Treatment Works for Children With Selective Mutism?
The purpose of this pilot study is to explore the outcome of a manual based treatment for children with Selective Mutism
- Trial name
- NCT00554749
- Testing
- Interventions at home, in the kindergarten/school
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- Regionsenter for barn og unges psykiske helse
Primary Progressive Aphasia
HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms
This study aims to evaluate the effectiveness of a therapy called High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for the treatment of the language deficits experienced by people with a type of Primary…
- Trial name
- NCT03805659
- Testing
- HD-tDCS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical College of Wisconsin
Stroke, Aphasia
Effects of Transcranial Direct Current Stimulation (tDCS) on Language
This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.
- Trial name
- NCT04166513
- Testing
- Targeted Transcranial Direct Current Stimulation, Active Control Transcranial Direct Current Stimulation, Phonologic-Focused Speech Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical College of Wisconsin
Language Disorders in Children
Training Grammar With Meaning
This study will enroll children between the ages of 4 and 6 years of age who exhibit significant difficulty developing language skills without any other handicapping conditions.
- Trial name
- NCT06250101
- Testing
- Enhanced Conversational Recast treatment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Arizona
Stroke, Aphasia
Digital Interventions in Neurorehabilitation: iTALKbetter
iTALKBetter will provide an app-based therapy for people with word retrieval difficulties who have had a stroke. This study aims to test the therapy application for people with naming difficulties through a small scale…
- Conditions
- Stroke, Aphasia, Anomia
- Trial name
- NCT04566081
- Testing
- iTalkBetter Trained Items, iTalkBetter Untrained Items
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University College, London
Aphasia
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia
Transcranial Magnetic Stimulation (TMS) has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies, many of which did not include a control group.
- Trial name
- NCT03651700
- Testing
- Active TMS, CILT
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- H. Branch Coslett
Childhood-Onset Fluency Disorder (Stuttering)
Effects of Ecopipam or Placebo in Adults With Stuttering (Speak Freely)
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase 2 exploratory study in adult subjects with childhood onset fluency disorder.
- Trial name
- NCT04492956
- Testing
- Ecopipam
- Where
- 9 sites in United States
- Volunteers
- 68 people
- Sponsor
- Emalex Biosciences Inc.
Dementia, Mild Cognitive Impairment
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Spanish Language Homes
This study aims to develop, evaluate, and commercialize an in-home supportive technology that is designed to alleviate anxiety, burden, and loneliness in spousal and familial caregivers of individuals with Alzheimer's disease…
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT05159596
- Testing
- In-Home Technology System, Limited In-Home Technology
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Hearing Loss, Idiopathic Sudden Sensorineural
Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment
The primary objective of the trial is the confirmation of the efficacy of AM-111 in the recovery of severe to profound idiopathic sudden sensorineural hearing loss (ISSNHL).
- Trial name
- ASSENT (NCT02809118)
- Testing
- AM-111 0.4 mg/ml, AM-111 0.8 mg/ml
- Where
- 51 sites in United States, Canada and 1 more
- Volunteers
- 56 people
- Sponsor
- Auris Medical, Inc.
Aphasia, Stroke
Post-Stroke Aphasia and Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Study
In this study the investigators will examine the efficacy of navigated excitatory repetitive transcranial magnetic stimulation (nerTMS) for the treatment of post stroke aphasia.
- Trial name
- PART (NCT01512264)
- Testing
- Magstim SuperRapid
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham