Clinical trials: Laparotomy
Gynecologic Surgical Procedures
Rectus Sheath Block for Analgesia After Gynecological Laparotomy
Thirty subjects undergoing laparotomy for Gynecologic oncology surgery will be prospectively enrolled and will receive a bilateral rectus sheath block (RSB) under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml…
- Trial name
- NCT06575699
- Testing
- Rectus sheath block, Thoracic Epidural Analgesia, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Surgical Wound, Wound Dehiscence, Surgical
Prophylactic Negative Pressure Wound Therapy for High Risk Laparotomy Wounds. A Randomized Prospective Clinical Trial.
Negative pressure wound closure technique (NPWT) has been widely introduced in different clinical settings. Most of the studies report it as an effective and cost-effective method to treat complicated surgical wounds or even open…
- Conditions
- Surgical Wound, Wound Dehiscence, Surgical, Surgical Site Infection, Dehiscence of Internal Surgical Wound
- Trial name
- NCT03716687
- Testing
- Prophylactic negative pressure wound dressing after laparotomy
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- St. Borbala Hospital
Anesthesia, Intravenous, Laparotomy
TCI vs Manually Controlled Infusion of Propofol
Anesthesia records for patients anesthetized with target controlled infusion of propofol and remifentanil will be matched with patients anesthezied with manyally controlled infusion.
- Conditions
- Anesthesia, Intravenous, Laparotomy, Airway Extubation
- Trial name
- NCT04266535
- Testing
- Target controlled infusion
- Volunteers
- 40 people
- Sponsor
- Regional Hospital West Jutland
Quality of Life, Postoperative Complications
Recovery After Emergency Laparotomy: a Prospective Observational Feasibility Study
Observational feasibility study using Patient Reported Outcomes (PRO) to assess quality of life and 'return to normal life' up to 1 year following emergency laparotomy
- Trial name
- REmLap (NCT02791633)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Dudley Group NHS Foundation Trust
Post-operative Milestones
Abdominal Binder and Steps Trial
Large lower abdominal incisions are still used in many types of common gynecologic surgeries. Patients may experience pain and restrictions to ambulation because of this, which can make healing after surgery harder and more…
- Trial name
- ABS (NCT04414384)
- Testing
- Abdominal Binder, Step Counter
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Abdominal Pain
A Comparison of Postoperative Outcomes Provided by a Continuous Preperitoneal Infusion Versus Ultrasound Guided Rectus Sheath Block for Midline Emergency Laparotomy
aim of this study is to compare the postoperative analgesia provided bya continuous preperitoneal infusion versus ultrasound guided rectus sheath block for midline emergency laparotomy. anticoagulated patients
- Trial name
- NCT03228797
- Testing
- an ultrasound guided rectus sheath block, multiholed catheter, an ultrasound guided rectus sheath block &multiholed catheter
- Volunteers
- 60 people
- Sponsor
- Dr Manar Mamdouh Fahmy Elsharkawi
Surgical Site Infection, Length of Stay
Prevena to Prevent Surgical Site Infection After Emergency Abdominal Laparotomy
Post-operative wound complications in abdominal surgery have a major impact on patient outcomes and the real impact of Closed incision negative pressure therapy (CINVt) is not clear in the literature moreover concerning its…
- Conditions
- Surgical Site Infection, Length of Stay, Seroma, Hematoma
- Trial name
- CiPNT/SSI (NCT04496180)
- Testing
- Closed incision negative pressure therapy versus standard dressing after emergency abdominal laparotomies
- Volunteers
- 334 people
- Sponsor
- University Hospital, Geneva
Incisional Hernia After Midline Laparotomy, Quality of Life (QOL)
NoPro - Norwegian Hernia Prophylaxis Study
A multicenter randomized controlled trial comparing midline laparotomy closures using the small-bite suture technique alone to those using the small-bite suture technique with an additional onlay prophylactic polypropylene mesh.
- Conditions
- Incisional Hernia After Midline Laparotomy, Quality of Life (QOL), Burst Abdomen, Surgical Site Infections
- Trial name
- NoPro (NCT06858020)
- Testing
- Prophylactic polypropylene onlay mesh
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Sykehuset Innlandet HF
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Peritoneal Inflammation, Peritoneum; Injury
Effect of Warmed Humidified CO2 on Peritoneum During Laparotomy
The operating theatre is deliberately made to be cold and dry to prevent bacteria from growing. The problem with this is that during open abdominal surgery, the intestine and the overlying peritoneum is exposed to cold dry air.
- Trial name
- NCT02975947
- Testing
- Humidified, warmed CO2 insufflation of open peritoneum using Fisher & Paykel's HUMIGARD (Fisher & Paykel Healthcare Ltd, Auckland, New Zealand), Standard heating
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Concord Repatriation General Hospital
Pain, Postoperative
Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty
This is a Phase 3, multicenter, randomized, double-blind, parallel-group, placebo-controlled efficacy and safety study of postoperative pain in adults who are scheduled for unilateral inguinal hernioplasty via open laparotomy…
- Trial name
- MATRIX-2 (NCT02525133)
- Testing
- XaraColl
- Where
- 24 sites in United States
- Volunteers
- 319 people
- Sponsor
- Innocoll
Fibroid Uterus
Robot-Assisted Laparoscopic Myomectomy Is an Improvement Over Laparotomy in Patients With a Limited Number of Fibroids
This is a retrospective, case-control study of 75 patients having undergone a robotic-assisted laparoscopic myomectomy were compared to patients having undergone myomectomy via laparotomy.
- Trial name
- NCT00910468
- Testing
- Robot-assisted Laparoscopic myomectomy
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ascher-Walsh, Charles, M.D.
Ruptured Ectopic Pregnancy
Laparascopy Versus Laparatomy in the Management of Ruptured Ectopic Pregnancy
Standard management for patients with ruptured ectopic pregnancies at our institution is treatment by laparotomy. This trail will investigate the feasibility of treatment with laparoscopy and will look at outcomes such as…
- Trial name
- NCT01932957
- Testing
- Laparotomy arm, Laparoscopy arm
- Where
- South Africa
- Volunteers
- 140 people
- Sponsor
- University of Pretoria
Mortality, Pediatric
Operative Duration as a Predictor of Mortality in Pediatric Emergency Surgery
Introduction Operative duration is an important but under-studied predictor of mortality in emergency laparotomies. Aims \& Objectives The objective of this study was to quantify the effect of duration of emergency laparotomy in…
- Conditions
- Mortality, Pediatric, Laparotomy, Emergencies
- Trial name
- NCT03270930
- Testing
- Emergency laparotomy
- Volunteers
- 213 people
- Sponsor
- Jawaharlal Nehru Medical College
Open Abdomen
An Adhesion Reduction Plan in the Management of the Surgical Open Abdomen
The purpose of this study is to determine whether an adhesion reduction plan, consisting of early adhesion prevention and application of a bioresorbable membrane is effective in reducing the severity of adhesions and the…
- Trial name
- NCT01010464
- Testing
- Adhesion Reduction Plan
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Neural Tube Defects, Spina Bifida
Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
The purpose of this study is to evaluate the feasibility of a fetoscopic surgical technique for antenatal correction of fetal myelomeningocele. Two surgical approaches will be utilized.
- Conditions
- Neural Tube Defects, Spina Bifida, Myelomeningocele, Chiari Malformation
- Trial name
- NCT03856034
- Testing
- Fetoscopy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- USFetus
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Pain, Postoperative, Anaplasia
the Effect of Doctor-nurse-patient Cooperative Analgesic Linkage Program on Movement Evoked Pain
1. To establish doctor-nurse-patient cooperative analgesic linkage program. 2. Evaluate the effect of doctor-nurse-patient cooperative analgesic linkage program on movement evoked pain after laparotomy for patients with…
- Trial name
- NCT03823846
- Testing
- Routine Dezocine injection, Adjusted Dezocine injection, Routine Dynastat or Flurbiprofen Axetil jinjection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Laparotomy
Supplemental Oxygen - Effect on Occurrence of Subsequent Cancer After Abdominal Surgery (Follow-up of the PROXI Trial)
Aim: to investigate the effect of a high inspiratory oxygen fraction (FiO2) given during and after laparotomy procedures on occurrence of a subsequent, new or recurrent, cancer diagnosis at a long-term follow-up.
- Trial name
- PROXI (NCT01723280)
- Testing
- Oxygen
- Where
- Denmark
- Volunteers
- 1,386 people
- Sponsor
- Lars S. Rasmussen
Surgical Site Infection
Comparison Of Outcome Of Antibiotic Coated Vicryl Vs Non-Coated Vicryl In Abdominal Fascial Closure After Laparotomy In Children
We are investigating outcome of antibiotic coated vicryl versus non coated vicryl in terms of rate of surgical site infection and lebgth of hospital stay in children after lalaprotomy for perforated viscera.
- Trial name
- NCT06129773
- Testing
- antibiotic coated vicryl used for fascial closure
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Muhammad Adeel Ashiq