Clinical trials: Large Vessel Occlusion
Coronary Artery Disease
Physicians International CT Utilization Registry 2
To determine the total plaque burden, plaque severity and composition of patients undergoing Cardiac CT who do not have any previous history of CVD. There are two cohorts: 1.
- Trial name
- Big PICTURE 2 (NCT02354196)
- Testing
- CCTA
- Where
- 2 sites in United States, India
- Volunteers
- healthy volunteers welcome
- Sponsor
- MDDX LLC
Large Artery Stiffness, Aortic Disease
Phenotyping Heterogeneity and Regionality of the Aorta
The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern.
- Conditions
- Large Artery Stiffness, Aortic Disease, Aortic Stenosis, Aortic Aneurysm
- Trial name
- PHaRAo (NCT05603520)
- Testing
- Collection of Clinical Data
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Collateral Circulation, Large-artery Occlusion
Study of Collateral Circulation in Patients With Symptomatic Intracranial Anterior Circulation Occlusion
Intracranial artery stenosis is the leading cause of stroke onset or recurrence in Asian. Multiple studies have shown that anterior circulation is most common in intracranial artery stenosis, especially the middle cerebral artery…
- Conditions
- Collateral Circulation, Large-artery Occlusion, Cerebral Infarction
- Trial name
- NCT04091412
- Testing
- Butylphthalide Soft Capsules
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Hebei Medical University
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Smartphone AI Assistance for Prehospital ECG Interpretation
Prehospital providers interpret 12-lead electrocardiograms (ECGs) under time pressure and without immediate expert support. Missed acute coronary occlusion - occlusion myocardial infarction (OMI) - delays reperfusion, while false…
- Conditions
- Acute Coronary Syndromes, ST Elevation Myocardial Infarction, Non-ST Elevated Myocardial Infarction, Myocardial Infarction (MI)
- Trial name
- ECG-IA (NCT07810686)
- Testing
- Smartphone large language model assistance (GPT-4o, version-locked)
- Where
- Switzerland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care
Anterior Large Vessel Occlusion Stroke
Prediction of Anterior Circulation Large Vessel Occlusion Stroke With EEG
This study is designed to evaluate the accuracy of saline electrode EEG in the prehospital diagnosis of LVO-a stroke.
- Trial name
- NCT06564129
- Testing
- electroencephalography
- Where
- China
- Volunteers
- 1,194 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Dementia Alzheimers, Dementia
Detecting Dementia in the Retina Using Optical Coherence Tomography
This retrospective case control explores the retinal features of dementia associated with neurodegenerative diseases, particularly Alzheimer's disease.
- Conditions
- Dementia Alzheimers, Dementia, Dementia, Vascular, Dementia Senile
- Trial name
- NCT03631069
- Where
- United Kingdom
- Volunteers
- 280,000 people, healthy volunteers welcome
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers
Study BT200-01 is a first in human (FIH) study in male and female normal human volunteers (NHVs) that uses an Integrated Protocol Design.
- Conditions
- Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis), Intracranial Arteriosclerosis
- Trial name
- NCT04103034
- Testing
- BT200, Desmopressin
- Where
- Austria
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Band Therapeutics
Acute Stroke
Ischemic Conditioning During Air tRansport Save penUmbral Tissue
The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic…
- Trial name
- ICARUS (NCT03481205)
- Testing
- Ischemic conditioning device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Enrique Leira
Stroke, Acute, Neuroprotection
Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion
The goal of this clinical trial is to determine if direct ischemic post-conditioning (IPostC) can alleviate ischemic-reperfusion injury (I/R) in patients who have undergone endovascular thrombectomy (EVT).
- Conditions
- Stroke, Acute, Neuroprotection, Ischemic Conditioning
- Trial name
- NCT06545734
- Testing
- Direct Ischemic Post-conditioning, Endovascular therapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Huanhu Hospital
Cerebrovascular Disorders
Identification of microRNAs Involved in Cerebral Collateral Regulation
Patients >18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will…
- Trial name
- microRNA (NCT03905434)
- Testing
- miRNA sampling
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Stroke, Acute, Thrombosis
RNA Sequencing Analysis in Large Vessel Occlusion Stroke DATA Bank
Introduction: the source of embolic stroke , in thrombotic embolism , is of unknown origin in 30-40% of cases. Fortunately , Mechanical thrombectomy provide a direct method to retrieve the stroke-incriminated clots from stroke…
- Trial name
- RNASA-LVOSB (NCT03490552)
- Testing
- mechanical thrombectomy
- Where
- Egypt
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Society of Minimally Invasive Neurological Therapeutic Procedures
Stroke, Acute
Prehospital Prediction of Large Anterior Vessel Occlusion
For the clinical benefit of intravenous thrombolysis "IVT" or intra-arterial thrombectomy "IAT" time is the most crucial factor. Reducing the time between stroke onset en treatment is therefore a major goal.
- Trial name
- PHPLAVO (NCT04442659)
- Testing
- pre hospital triage tool
- Where
- Netherlands
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Hemorrhagic Stroke, Ischemic Stroke
Early Feasibility Study of the SENSE Device
A single site, study of the SENSE device in up to 20 study subjects, (five healthy controls and five each with ICH, AIS with LVO and AIS without LVO) in whom SENSE can be applied within 24 hours of stroke symptom onset.
- Trial name
- NCT03827720
- Testing
- SENSE Device
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sense Diagnostics, LLC