Clinical trials: Large Vessel Occlusion
Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation
Sodium Sivelestat With Mechanical Thrombectomy for Acute Stroke: A Pilot Study
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as the standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation, Large Vessel Occlusion, Thrombectomy
- Trial name
- NCT07196605
- Testing
- Sodium Sivelestat
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke Code, Large Vessel Occlusion
Evaluation of a Point-of-care Lateral Flow Assay in Glial Fibrillary Acidic Protein (GFAP) and D-dimer in Diagnosis of Large Vessel Occlusion Acute Ischemic Stroke in a Pediatric Hospital
The goal of this study is to test the efficacy of a rapid bedside blood test in determining if a stroke is happening in children who present to the emergency department with stroke symptoms.
- Conditions
- Stroke Code, Large Vessel Occlusion, Acute Ischemic Stroke
- Trial name
- NCT07474675
- Testing
- Point of Care Rapid Assay
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Children's Hospital
Ischemic Stroke, Large Vessel Occlusion
Advancing Reperfusion Therapy for Ischemic Stroke: Direct Transfer to Angiography Suite for Patients With Suspected Large Vessel Occlusion
The investigators initiated a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) controlled trial to evaluate the efficacy and safety of the direct transfer to angiography suite (DTAS) triage strategy…
- Trial name
- ARTS-DTAS (NCT07460713)
- Testing
- direct transfer to angiography suite, conventional CT/MRI triage strategy
- Where
- China
- Volunteers
- 568 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke From Large Vessel Occlusion
Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Stroke remains a predominant global public health challenge, ranking as the third leading cause of death and the fourth leading contributor to disability-adjusted life years (DALYs).
- Trial name
- AMASS2 (NCT07365475)
- Testing
- 20% human serum albumin
- Volunteers
- 306 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke (AIS), Acute Ischemic Stroke From Large Vessel Occlusion
Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke
Since 2015, many randomized trials have shown that endovascular thrombectomy improve functional outcomes in acute ischemic stroke patients with large vessel occlusion.
- Trial name
- XL-STROKE (NCT06210633)
- Testing
- medical management, endovascular thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhongming Qiu
Acute Ischemic Stroke From Large Vessel Occlusion
The Preliminary Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Albumin-assisted therapy has demonstrated good safety and potential neuroprotective effects following mechanical thrombectomy. To further systematically evaluate its efficacy and safety, we are conducting a Phase IIa clinical…
- Trial name
- NCT07294391
- Testing
- Human serum albumin infusion 20%
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke From Large Vessel Occlusion
Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter
The objective of this study is to assess the safety and effectiveness of mechanical thrombectomy (MT) using the ANA funnel catheter in its intended use, which is to facilitate the navigation and deployment of other neurovascular…
- Trial name
- ATHENA (NCT06370182)
- Testing
- ANA Funnel Catheter, Control
- Where
- 22 sites in United States, France and 3 more
- Volunteers
- 327 people
- Sponsor
- Anaconda Biomed S.L.
Stroke, Ischemic, Large Vessel Occlusion
Biomarkers algOrithm for strOke diagnoSis and Treatment Resistance Prediction
Triage of acute ischemic stroke (AIS) patients is critical, to decrease time to treatment, and improve functional outcome. The therapeutic standard of care for AIS consecutive to large vessel occlusion (LVO) is the association of…
- Trial name
- BOOST (NCT04726839)
- Testing
- Standard of care for stroke management and evaluation of functionnal outcome at 3 months
- Where
- 4 sites in France
- Volunteers
- 3,880 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Ischemic Stroke, Large Vessel Occlusion
Evaluation of the CONDA Stent Retriever in Acute Ischemic Stroke
The goal of this study is to evaluate the safety and performance of the CONDA stent retriever in patients with acute ischemic stroke due to large vessel occlusion, treated within 24 hours of symptom onset.
- Trial name
- ARTEMIS (NCT07174505)
- Testing
- Mechanical Thrombectomy using the CONDA Stent Retriever
- Where
- 2 sites in Hungary, Spain
- Volunteers
- 50 people
- Sponsor
- Anaconda Biomed S.L.
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase vs Medical Management in 4.5-24h LVO no Access to EVT
The goal of this clinical trial is to learn if tenectplase works to acute ischemic stroke (AIS) with onset 4.5-9 hours. It will also learn about the safety of tenectplase in AIS with onset 4.5-9 hours.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Tenecteplase, Thrombolysis
- Trial name
- TNK LATE (NCT07168278)
- Testing
- TNK, Standard medical treatment
- Where
- China
- Volunteers
- 794 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Ischemic Stroke, Acute, Large Vessel Occlusion
Image Detection of Impaired Microcirculatory Reperfusion
Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain.
- Trial name
- ID IMR (NCT07099599)
- Testing
- CT Perfusion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Stroke, Large Vessel Occlusion
Mechanical Thrombectomy Blood Flow Reversal
The goal of this study is to reduce the chance of complications during mechanical thrombectomy, which is a procedure to remove blockages from the brain.
- Trial name
- NCT06721338
- Testing
- Mechanical thrombectomy via blood flow reversal using BOBBY balloon guide catheter
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- MediSys Health Network
Stroke, Acute Ischemic, Albumin
Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients
The purpose of this study is to investigate the safety and feasibility of intra-arterial albumin infusion for patients with acute ischemic stroke after successful thrombectomy and to further explore the optimal dose of albumin…
- Conditions
- Stroke, Acute Ischemic, Albumin, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- NCT05953623
- Testing
- Albumin
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke From Large Vessel Occlusion, Endovascular Thrombectomy
Efficacy and Safety of Plasma Adsorption Combined With EVT for AIS-LVO
The purpose of this study is to determine the efficacy and safety of plasma adsorption for patients of acute ischemic stroke who underwent endovascular thrombectomy due to large vessel occlusion of anterior circulation.
- Trial name
- PROMOTE-EVT (NCT07042490)
- Testing
- Plasma adsorption, Endovascular Thrombectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yi Yang
Large Vessel Occlusion, Acute Ischemic Stroke
Cerebral Large Vessel Occlusion Stroke Multiomics Biosample Cohort
This multicenter, ambispective cohort study establishes a comprehensive multiomics biobank from five stroke centers, encompassing thrombi, intracranial blood, peripheral arterial/venous blood, and…
- Trial name
- CLOMB (NCT06963489)
- Testing
- Not applicable- observational study
- Where
- 5 sites in China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Acute Ischemic Stroke, Large Vessel Occlusion
Acute Ischemic Stroke EndoVascular Therapy: a Multicenter REGISTRY Study
A Multicenter Registry of Endovascular Treatment for Acute Ischemic Stroke.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Thrombosis
- Trial name
- NCT05864638
- Testing
- Endovascular treatment
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Changhai Hospital
Acute Ischemic Stroke, Large Vessel Occlusion
Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment
The goal of this clinical trial is to learn if semaglutide works to treat acute ischemic stroke (AIS). It will also learn about the safety of semaglutide in AIS.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Neuroprotective Drugs, Endovascular Treatment
- Trial name
- GALLOP2 (NCT06788626)
- Testing
- Semaglutide 0.5 mg, Standard medical treatment
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Wei Hu
Acute Ischemic Stroke, Stroke
Early Feasibility Study of RapidPulseTM Aspiration System for Patients With Acute Ischemic Stroke
The goal of this clinical trial is to assess the initial safety and performance of the RapidPulseTM Aspiration System in patients experiencing acute ischemic stroke within 24 hours since the onset of stroke symptoms, or last…
- Conditions
- Acute Ischemic Stroke, Stroke, Large Vessel Occlusion, Mechanical Thrombectomy
- Trial name
- PULSE-C (NCT05899036)
- Testing
- RapidPulseTM Aspiration System
- Where
- 2 sites in Paraguay, Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- RapidPulse, Inc
Ischemic Stroke, Large Vessel Occlusion
Combination of Hypothermia and Thrombectomy in Acute Stroke
The goal of this clinical trial is to test the combination of hypothermia and endovascular treatment in acute stroke patients with large vessel occlusion.
- Conditions
- Ischemic Stroke, Large Vessel Occlusion, Endovascular Treatment
- Trial name
- COTTIS-2 (NCT06301412)
- Testing
- hypothermia
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University of Freiburg
Large Vessel Occlusion, Stroke Acute
Rescue Stenting and Intravenous Thrombolysis In Patients With Large Vessel Ischemic Stroke
Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are the standard of care for treating selected patients with acute large-vessel occlusion stroke (LVOS).
- Conditions
- Large Vessel Occlusion, Stroke Acute, Thrombolysis, Rescue Stenting
- Trial name
- STARS (NCT06727006)
- Where
- 7 sites in Italy
- Volunteers
- 400 people
- Sponsor
- ASST Santi Paolo e Carlo