Clinical trials: Laryngectomy
OBSTRUCTIVE SLEEP APNEA
Obstructive Apnea in Patients Submitted to Partial Laryngectomy
The investigators intend to study the prevalence of obstructive apnea in patients submitted to partial laryngectomy by larynx cancer. Volunteers will be evaluated using polissonografy.
- Trial name
- NCT01157286
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital do Servidor Publico Estadual
Squamous Cell Carcinoma, Laryngeal Cancer
Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer
The purpose of this prospective, multi-institutional, observational cohort study is to determine if an initial surgical approach leads to better function and quality of life than primary chemoradiation in a subset of patients…
- Trial name
- NCT01089803
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- University of Minnesota
Larynx Stenosis, Larynx Disease
Laryngeal Allograft Transplantation
The purpose of this proposed study is to obtain safety and efficacy data on human laryngeal allograft transplantation in an effort to safely use these procedures as a viable reconstructive option for patients with severe…
- Conditions
- Larynx Stenosis, Larynx Disease, Laryngectomy, Larynx
- Trial name
- NCT03269396
- Testing
- Larynx Allograft Transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Laryngectomy; Status
Long Term Effects of Heat and Moisture Exchangers (HMEs)
Assessment of long term effect of Provox Life HME use on pulmonary symptoms in laryngectomized patients.
- Trial name
- NCT06084611
- Testing
- Provox Life
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Atos Medical AB
Total Laryngectomy
Short-term Clinical Feasibility of the New Provox Vega 22.5 Voice Prosthesis
The purpose of this study is to investigate the performance of a new voice prosthesis in comparison with the Provox2 and the Provox ActiValve voice prosthesis in 15 laryngectomized patients.
- Trial name
- NCT00743262
- Testing
- Provox voice prosthesis
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Atos Medical AB
Oropharyngeal Dysphagia, Laryngectomy; Status
CPAP to Improve Swallow Function Post Total Laryngectomy
Investigator initiated prospective study to determine whether use of Continuous Positive Airway Pressure (CPAP) can improve the swallow function in patients who underwent total laryngectomy and are experiencing difficulty…
- Trial name
- NCT03328702
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, Davis
Cancer Larynx, Total Laryngectomy
Effects of Propofol-dexmedetomidine on Immune Function in Patients With Cancer Larynx
The aim of this prospective, randomized clinical study is to compare between propofol and isoflurane on perioperative immune cell populations and function in patients undergoing total laryngectomy surgery.
- Trial name
- NCT02739958
- Testing
- Propofol group, Isoflurane group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Laryngectomy, Total Pharyngo-laryngectomy
Correlation Between Personnality Traits and Ability to Learn Oroesophageal Voice
After total laryngectomy and loss of laryngeal phonation, the oro-oesophageal voice (VOO) is a communication option for the patient.
- Trial name
- CoPerVOO (NCT06856863)
- Testing
- Test of personality : questionnary
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Larynx Cancer, Pharynx Cancer
Use of Human Dehydrated Amnion Chorion Allograft in Laryngectomy/Pharyngectomy
This trial aims to determine if intra-operative use of human dehydrated amnion chorion allograft improves post-operative patient healing outcomes.
- Conditions
- Larynx Cancer, Pharynx Cancer, Pharyngocutaneous Fistula
- Trial name
- NCT03479463
- Testing
- Dehydrated human amnion/chorion membrane
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- MiMedx Group, Inc.
Total Laryngectomy
Short-term Clinical Feasibility of the Provox XtraHMEs for Pulmonary Rehabilitation After Total Laryngectomy
This study is a short term feasibility study that aims to investigate patient satisfaction with and performance of new Provox Xtra HME in 20 laryngectomized patients.
- Trial name
- N08HME (NCT00942903)
- Testing
- Provox Xtra HME
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Atos Medical AB
Laryngectomy; Status
Pilot Feasibility Study of Peristomal Adhesives
Loss of voice is one of the greater consequences of total laryngectomy. The voice prosthesis allows the patients to speak again in a very short time but forces them to use one hand when speaking.
- Trial name
- NCT05762497
- Testing
- Moldable adhesive
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Laryngeal Squamous Cell Carcinoma
Decisional Regret in Open Partial Horizontal Laryngectomy
Prospective multicentric study to evaluate decisional regret and psychometric and functional outcomes in patient previously treated with Open Horizontal partial Laryngectomy
- Trial name
- NCT06805071
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Laryngectomy
Assessment of the New Provox Life System for Pulmonary Health and Quality of Life After Total Laryngectomy
Background: The benefits of using Heat and Moisture Exchangers (HMEs) for pulmonary rehabilitation after total laryngectomy are widely known.
- Trial name
- NCT04974801
- Testing
- Provox Life, Usual Care
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Atos Medical AB
Laryngectomy
Clinical Feasibility of a New Voice Prosthesis
The objective of this clinical investigation is to evaluate the short-term clinical feasibility of a new voice prosthesis and explore its acceptability, limitations and advantages.
- Trial name
- NCT05079386
- Testing
- New Voice Prosthesis
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Atos Medical AB
Patient-controlled Analgesia
The Comparison of the Analgesic Effects of Dezocine and Sufentanil in Patient-controlled Analgesia After Laryngectomy
Laryngeal cancer is one of the most common tumors in otolaryngology. In China, it accounts for 1-5% of all malignancies and has an incidence of 1.13 per 100,000.
- Trial name
- NCT06000137
- Testing
- Dezocine, Sufentanil injection, Flurbiprofen
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Dysphonia, Aphonia
A Personalized Voice Restoration Device for Patients With Laryngectomy
The investigators will conduct a pilot experiment for a novel and personalized method for voice restoration using machine learning applied to surface EMG (sEMG) signal from articulatory muscles of the face and the neck allowing…
- Trial name
- NCT05479643
- Testing
- Surface Electromyography
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Laryngeal Cancer
Study of the Risk of Pharyngocutaneous Fistula in a Population of Patients Undergoing Total Laryngectomy and Creation of a Score for Pre-operative Risk Stratification.
Multicenter retrospective study of a cohort of patients affected by laryngeal carcinoma and subjected to total laryngectomy surgery at the centers participating in the reference period and responding to inclusion criteria.
- Trial name
- NCT06308016
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Regina Elena Cancer Institute
Head and Neck Cancer
TPF Plus Radiotherapy and Cetuximab to Avoid Total Laryngectomy in Patients With Larynx Cancer
A Phase II Trial With Radiotherapy Plus Cetuximab to Evaluate Specific Survival Free of Laryngectomy in Patients With Resectable and Locally Advanced Larynx Cancer, After Treatment With TPF Chemotherapy.
- Trial name
- NCT00765011
- Testing
- TPF, radiotherapy and cetuximab, H&N surgery
- Where
- 17 sites in Spain
- Volunteers
- 94 people
- Sponsor
- Grupo Español de Tratamiento de Tumores de Cabeza y Cuello
Laryngeal and Hypopharyngeal Tumors
Study Title: Oncological and Functional Results After Total Laryngectomy and Pharyngolaryngectomy
Salvage total laryngectomy (TL) and total pharyngolaryngectomy (TPL) are the gold standard for most recurrent laryngeal and hypopharyngeal tumors as well as in patients with contraindication for chemoradiotherapy (CRT).
- Trial name
- TL&TPL (NCT07287865)
- Testing
- surgical flap
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Malignant Tumor of the Larynx
Stapler Versus Conventional Pharyngeal Repair After Total Larygectomy
This study was done to investigate the efficacy and safety of the linear stapler closure of the pharynx after total laryngectomy.
- Trial name
- NCT06256263
- Testing
- total laryngectomy
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Mansoura University