Clinical trials: Laryngectomy
Esophageal Neoplasm, Laryngeal Neoplasms
Feasibility Study CORPPS
The incidence of cancer in France has increased by +135% to reach nearly 400,000 new cases in 2018. The ten-year cancer control strategy 2021-2030 and the health innovation plan have defined strategic axes.
- Trial name
- FAISA-CORPPS (NCT05406024)
- Testing
- Digital platform
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Patient-controlled Analgesia
The Comparison of the Analgesic Effects of Dezocine and Sufentanil in Patient-controlled Analgesia After Laryngectomy
Laryngeal cancer is one of the most common tumors in otolaryngology. In China, it accounts for 1-5% of all malignancies and has an incidence of 1.13 per 100,000.
- Trial name
- NCT06000137
- Testing
- Dezocine, Sufentanil injection, Flurbiprofen
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Laryngeal Cancer
Comparison of 2 Cefazolin Prophylactic Protocol in Laryngectomy Patients
Patients who need major head \& neck surgery are at risk of post operative wound infection. In spite of role of antibiotics in prophylaxis of clean contaminated head and neck surgery has been well documented, controversy exists…
- Trial name
- NCT00467948
- Testing
- cefazolin
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
Laryngeal Cancer, Hypopharynx Cancer
A Novel Modified Tracheo-Esophageal Voice Prosthesis for Total Laryngectomy Patients
This study is being conducted at Healthcare Global Enterprises Ltd to evaluate the role of a novel Tracheo-Esophageal voice Prosthesis for total laryngectomy +/- partial pharyngectomy patients.
- Trial name
- TEP (NCT03039465)
- Testing
- Modified Trans-Esophageal Prosthesis
- Where
- India
- Volunteers
- 50 people
- Sponsor
- HealthCare Global Enterprise Ltd.
Patients With Total Laryngectomy and Their Close Relatives
FRENCH THERAPEUTIC EDUCATION PROGRAM AIMING TO IMPROVE LARYNGECTOMIZED PATIENTS' AND THEIR FAMILY CAREGIVER'S QUALITY OF LIFE
The therapeutic education of patients and their close relations is, as yet, poorly developed in France in the field of oncology (Pérol2007), in particular for cancers of the upper aerodigestive tract (Allison2010).
- Trial name
- PETAL2 (NCT04569500)
- Testing
- PETAL program
- Where
- France
- Volunteers
- 264 people
- Sponsor
- University Hospital, Caen
Total Laryngectomy
Pre-operative Counselling in Laryngectomized Patients
The investigators aim to verify the effects of pre-operative Speech-Language Pathology (SLP) counselling on patients undergoing total laryngectomy in terms of levels of distress, post-traumatic stress symptoms, anxious-depressive…
- Trial name
- NCT04491487
- Testing
- pre-operative counselling
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Laryngectomy; Status
Pilot Feasibility Study of Peristomal Adhesives
Loss of voice is one of the greater consequences of total laryngectomy. The voice prosthesis allows the patients to speak again in a very short time but forces them to use one hand when speaking.
- Trial name
- NCT05762497
- Testing
- Moldable adhesive
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Laryngectomy, Voice
Estimation of Benefit From Regular Versus Leakage-related Exchange of Voice Prosthesis in Patients Post Laryngectomy.
The tracheoesophageal voice with voice prosthesis is currently the mainstay of voice rehabilitation post laryngectomy. The primary surgical technique of tracheoesophageal fistula formation with insertion of prosthesis and quick…
- Conditions
- Laryngectomy, Voice, Prosthesis Failure
- Trial name
- RvLPE (NCT04268459)
- Testing
- Provox prosthesis exchange
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Warsaw
Laryngectomy
Cost-effectiveness Analysis of Vocal Rehabilitation With Strengthened Tracheoesophageal Voice Implant Prosthesis Versus Standard Voice Prosthesis in Case of Repeated Intra-prosthetic Leakage After Total Laryngectomy
The purpose of this study is to determine the cost-effectiveness of vocal rehabilitation with reinforced inter-tracheoesophageal voice prosthesis versus standard voice prosthesis in case of repeated intra-prosthetic leakage in…
- Trial name
- PHRASAL (NCT04100954)
- Testing
- Reinforced prosthesis, Standard prosthesis
- Where
- 13 sites in France
- Volunteers
- 81 people
- Sponsor
- Nantes University Hospital
Oropharyngeal Dysphagia, Laryngectomy; Status
CPAP to Improve Swallow Function Post Total Laryngectomy
Investigator initiated prospective study to determine whether use of Continuous Positive Airway Pressure (CPAP) can improve the swallow function in patients who underwent total laryngectomy and are experiencing difficulty…
- Trial name
- NCT03328702
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, Davis
Cognitive Aging, Hyposmia
Mechanical and Sensorial Training in the Olfactive Rehabilitation of Patients With Total Laryngectomy
To assess the efficacy of two olfactory rehabilitation protocols (Nasal Airflow-Inducing Maneuver (NAIM) with or without ol-factory training) on olfactory function (sniffing stick test) and quality of life (questionnaire Self-MOQ…
- Conditions
- Cognitive Aging, Hyposmia, Total Laryngectomy
- Trial name
- OLFAC-TL (NCT07122037)
- Testing
- DosMedical Smell Training Set, Nasal Airflow Inducing Maneuver
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University Hospital of Mont-Godinne
Carcinomatous Disease
Establishment of an Artificial Larynx After Total Laryngectomy
This study aims to evaluate the effectiveness of an artificial larynx on the restoration of laryngeal functions, mainly breathing and swallowing.
- Trial name
- LA (NCT01474005)
- Testing
- PROTIP MEDICAL ( Artificial larynx prosthesis)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Strasbourg, France
Malignant Tumor of the Larynx
Stapler Versus Conventional Pharyngeal Repair After Total Larygectomy
This study was done to investigate the efficacy and safety of the linear stapler closure of the pharynx after total laryngectomy.
- Trial name
- NCT06256263
- Testing
- total laryngectomy
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Mansoura University
Total Laryngectomy Patients Who Use Voice Prostheses
Mixed-species Biofilms and Silicone Device Longevity
The purpose of this study is to determine whether the mix of microbial species isolated from biofilm-clogged voice prostheses is specific to each participant, whether the microbes are orally-derived and whether the presence of…
- Trial name
- NCT02507401
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Aberdeen
Laryngectomy; Status
Long Term Effects of Heat and Moisture Exchangers (HMEs)
Assessment of long term effect of Provox Life HME use on pulmonary symptoms in laryngectomized patients.
- Trial name
- NCT06084611
- Testing
- Provox Life
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Atos Medical AB
Cutaneous Fistula, Laryngectomy
Effect of Cervical Epidural Analgesia on the Occurrence of Pharyngocutaneous Fistula
Pharyngocutaneous fistula (PCF) is the most commonly reported postoperative complication in total laryngectomy patients. PCF significantly increases morbidity, length of hospitalization, and cost of care, in addition to delaying…
- Trial name
- NCT02870556
- Testing
- cervical epidural analgesia
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Laryngeal Squamous Cell Carcinoma
Decisional Regret in Open Partial Horizontal Laryngectomy
Prospective multicentric study to evaluate decisional regret and psychometric and functional outcomes in patient previously treated with Open Horizontal partial Laryngectomy
- Trial name
- NCT06805071
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Laryngeal Neoplasm
The Efficacy of Superficial Cervical Block Application in Postoperative Analgesia Management in Patients Undergoing Total Laryngectomy and Bilateral Neck Dissection
The goal of this clinical trial is to evaluate the efficacy of the superficial cervical block in postoperative pain management for patients undergoing total laryngectomy and bilateral neck dissection.
- Trial name
- NCT06852651
- Testing
- Superficial Cervical Block (SCB) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Total Laryngectomy
Long-term Clinical Feasibility of the New Indwelling Provox Vega 20 Voice Prosthesis
The purpose of this study is to investigate long-term clinical feasibility of a new voice prosthesis and insertion system Provox Vega 20 with SmartInserter) for voice rehabilitation after total laryngectomy.
- Trial name
- NCT00661570
- Testing
- Provox Vega voice prosthesis (20 Fr)
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Atos Medical AB
Head and Neck Cancer
S9709, Laser Surgery Plus Radiation Therapy in Treating Patients With Early Stage Cancer of the Larynx
RATIONALE: Laser surgery for cancer of the larynx may have fewer side effects and improve recovery. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003040
- Testing
- laser surgery, radiation therapy
- Where
- 12 sites in United States
- Volunteers
- 42 people
- Sponsor
- SWOG Cancer Research Network