Clinical trials: Laryngectomy, open to volunteers
Cancer, Otorhinolaryngeal
Rehabilitation Improved by Early Detection of Fisyulas Post (Pharyngo) -Total Laryngectomy by Cytokine Measurement on Drainage Fluid on the Second Post-Operative Day
Post-pharyngo-laryngectomy fistula is a frequent surgical complication, resulting in delayed patient management and reduced quality of life.
- Trial name
- RADEFILAC (NCT06604494)
- Testing
- early feeding resumption, late feeding resumption
- Where
- 7 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Clermont-Ferrand
Patients With Total Laryngectomy and Their Close Relatives
FRENCH THERAPEUTIC EDUCATION PROGRAM AIMING TO IMPROVE LARYNGECTOMIZED PATIENTS' AND THEIR FAMILY CAREGIVER'S QUALITY OF LIFE
The therapeutic education of patients and their close relations is, as yet, poorly developed in France in the field of oncology (Pérol2007), in particular for cancers of the upper aerodigestive tract (Allison2010).
- Trial name
- PETAL2 (NCT04569500)
- Testing
- PETAL program
- Where
- France
- Volunteers
- 264 people
- Sponsor
- University Hospital, Caen
Laryngectomy, Total Pharyngo-laryngectomy
Correlation Between Personnality Traits and Ability to Learn Oroesophageal Voice
After total laryngectomy and loss of laryngeal phonation, the oro-oesophageal voice (VOO) is a communication option for the patient.
- Trial name
- CoPerVOO (NCT06856863)
- Testing
- Test of personality : questionnary
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Squamous Cell Carcinoma
European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]
ELOS is a prospective, randomized, open-label, controlled, two-armed parallel group, phase II multicentre trial in local advanced stage III, IVA/B head and neck squamous cell carcinoma of the larynx or hypopharynx (LHNSCC) with…
- Conditions
- Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma Stage III, Laryngeal Squamous Cell Carcinoma Stage IV
- Trial name
- ELOS (NCT06137378)
- Testing
- KEYTRUDA®
- Where
- 9 sites in Germany
- Volunteers
- 140 people
- Sponsor
- University of Leipzig
ORL Cancer
Acceptability and Benefits of an Onco-sexology Program for Laryngectomy Patients and Their Partners
Single-centre prospective pilot study designed to demonstrate the acceptability of onco-sexology management for laryngectomy patients and their partners in order to improve their perception of their intimate life.
- Trial name
- ABSENS (NCT06517355)
- Testing
- In this research, the procedure under study is represented:
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Institut Claudius Regaud
Laryngectomy
Post-operative Use of New Adhesive After Total Laryngectomy
The goal of this clinical trial is to evaluate the feasibility, safety, and performance of the new adhesive when used in the immediate post-operative period after total laryngectomy.
- Trial name
- NCT07366281
- Testing
- Provox Life Comfort Adhesive
- Where
- 3 sites in Netherlands
- Volunteers
- 25 people
- Sponsor
- Atos Medical AB
Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Locally Advanced Laryngeal Squamous Cell Carcinoma
Window of Opportunity in Preserving Laryngeal Function Trial
This trial will study the safety and tolerability and disease survival rates in adult patients with recurrent/metastatic (R/M) HNSCC when treated with carboplatin or cisplatin, paclitaxel, and toripalimab.
- Conditions
- Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Locally Advanced Laryngeal Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma
- Trial name
- WOLF (NCT07423078)
- Testing
- Toripalimab, Carboplatin, Cisplatin
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Matthew Spector
Laryngectomy
A Randomized Trial Comparing Routine Use of the ActiValve to Standard Voice Prostheses
The goal of this clinical research study is to learn if regular use of Provox® ActiValve® by patients after a total laryngectomy with TEP can decrease the number of VP device replacements needed annually.
- Trial name
- NCT07369050
- Testing
- Provox® ActiValve®
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- M.D. Anderson Cancer Center
Laryngectomy; Status, Laryngeal Cancer
Workshops and Exchange Groups for Laryngectomized Patients
This research is conducted with the aim of improving the quality of life of laryngectomized patients and their entourage. Worldwide, there are 185,000 new cases of laryngeal cancer per year.
- Trial name
- GELAT (NCT06077643)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgery Site Fistula
Hypopharynx ICG to Reduce the Fistula Rate in Patients Undergoing Salvage Laryngectomy
A laryngectomy involves removing the voice box from the throat. After the voice box has been removed from the throat, the surgeon sews the throat closed.
- Trial name
- NCT05350540
- Testing
- ICG dye
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Total Laryngectomy
Early Feeding TL Trial
This is a randomized, single-center phase 2 study comparing early versus delayed oral feeding after total laryngectomy. Dysphagia-related outcomes will be assessed using the MDADI preoperatively, and on postoperative days 14 (±7)…
- Trial name
- NCT07919821
- Testing
- oral intake
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Larynx Carcinoma
The Role of the Free/Pedunculated Flap in Total Laryngectomy After (Chemo-)Radiotherapy Failure for Laryngeal Carcinoma: Impact on the Risk of Pharyngocutaneous Fistula (PCF)
Multicenter, prospective, randomized study aimed at evaluating the difference in risk of PCF after salvage laryngectomy in two groups of patients: one cohort treated with Total Laryngectomy (LT) with primary suture, a second…
- Trial name
- NCT06287034
- Testing
- Primary suture
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Regina Elena Cancer Institute
Dysphonia, Aphonia
A Personalized Voice Restoration Device for Patients With Laryngectomy
The investigators will conduct a pilot experiment for a novel and personalized method for voice restoration using machine learning applied to surface EMG (sEMG) signal from articulatory muscles of the face and the neck allowing…
- Trial name
- NCT05479643
- Testing
- Surface Electromyography
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Speech Disorders, Speech Dysfunction
Gender Disparities in Voice Outcomes After Tracheoesophageal Puncture in Total Laryngectomy Patients (UC Davis)
To perform a multi-site prospective study assessing, both subjectively and objectively, the gender disparities in speech outcomes of patients using TEP after total laryngectomy.
- Conditions
- Speech Disorders, Speech Dysfunction, Laryngectomy; Status, Tracheoesophageal Prosthesis
- Trial name
- NCT05489965
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis