Clinical trials: Laser Endomicroscopy
Irritable Bowel Syndrome (IBS)
Confocal Endomicroscopy Utility (p-CLE) in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. It has prevalence in general population of 5-20% and is more common in women and young adults.
- Trial name
- NCT02651532
- Testing
- Confocal Laser Endomicroscopy
- Where
- Ecuador
- Volunteers
- 74 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Peripheral Pulmonary Lesions (PPLs)
CLE vs. ROSE for Ex Vivo Lung Biopsy Assessment
The goal of this observational study is to evaluate the diagnostic efficacy of Confocal Laser Endomicroscopy (CLE) compared to Rapid On-Site Evaluation (ROSE) for ex vivo lung biopsy specimens obtained via bronchoscopy.
- Trial name
- NCT07725510
- Testing
- Ex Vivo Confocal Laser Endomicroscopy (CLE) Imaging and Interpretation, Rapid On-Site Evaluation (ROSE) Imaging and Interpretation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Lung Carcinoma
Needle-Based Confocal Laser Endomicroscopy for Diagnosis of Lung Cancer in Patients With Peripheral Pulmonary Nodules
This clinical trial compares the addition of needle-based confocal laser endomicroscopy (nCLE) and fluorescein to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS TBNA) with EBUS TBNA alone for the diagnosis…
- Trial name
- NCT05556525
- Testing
- Fluorescein, Image-Guided Needle Confocal Laser Endomicroscopy, Ultrasound-Guided Transbronchial Needle Aspiration
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Crohn's Disease
Impact of Diet and Lifestyle Modification on the Intestinal Barrier Integrity in Crohn's Disease
The goal of this prospective interventional study is to evaluate whether the targeted avoidance of a particular food that was diagnosed to be disruptive for the intestinal barrier during confocal laser endomicroscopy (CLE)…
- Trial name
- LeakyDiet (NCT06719778)
- Testing
- Two-stage nutritional therapy concept
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universität Duisburg-Essen
Colorectal Cancer, Colorectal Adenoma
Molecular Imaging of Epidermal Growth Factor Receptor in Colorectal Neoplasia Using Confocal Laser Endomicroscopy
The study aims to: 1. Achieve molecular imaging of EGFR in patients with colorectal neoplasia in vivo using confocal laser endomicroscopy. 2.
- Trial name
- NCT01372189
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shandong University
Lower Gastrointestinal Disorders
Validation of Clinical Efficacy and Development of New Diagnostic Algorithm of Probe-based Confocal Laser Endomicroscopy in Patients With Lower Gastrointestinal Disorder
The aims of this research are to validate and develop of therapeutic strategies for patients with colorectal lesions in real time through pCLE(probe-based confocal laser endomicroscopy).
- Trial name
- NCT02091895
- Testing
- probe-based confocal laser endomicroscopy
- Where
- South Korea
- Volunteers
- 311 people
- Sponsor
- Yonsei University
Barrett's Esophagus
Confocal Laser Endomicroscopy vs Conventional Histology for the Identification of Intestinal Metaplasia
Real-time Diagnosis of Barrett's Esophagus: Comparing Confocal Laser Endomicroscopy with Conventional Histology for the Identification of Specialized Intestinal Metaplasia
- Trial name
- NCT02632682
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Minnesota Institute for Minimally Invasive Surgery
Gastric Intestinal Metaplasia, Confocal Laser Endomicroscopy
A Comparison of pCLE Based Targeted Biopsy and WLE Based Standard Biopsy in Staging the Operative Link on Gastric Intestinal Metaplasia (OLGIM): A Randomized，Cross-over Study
Gastric intestinal metaplasia (GIM) is an important premalignant lesion for gastric cancer. Precisely surveillance of patients with GIM may result in early detection and improved prognosis.
- Conditions
- Gastric Intestinal Metaplasia, Confocal Laser Endomicroscopy, Operative Link on Gastric Intestinal Metaplasia, Biopsy
- Trial name
- NCT02930616
- Testing
- Patients in Group 1 will receive pCLE at first and WLE 2 months later, patients in Group 2 will receive WLE at first and pCLE 2 months later.
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shandong University
Gastric Cancer, Intestinal Metaplasia
New Classification of Stomach Using Probe-based Confocal Laser Endomicroscopy
The aim of the present study was to propose a new pCLE classification of gastric pit patterns and vessel architecture, and to assess the accuracy and interobserver agreement of this new pCLE classification system in the stomach.
- Conditions
- Gastric Cancer, Intestinal Metaplasia, Atrophic Gastritis, Inflammation
- Trial name
- NCT01896310
- Testing
- probe-based confocal laser endomicroscopy
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Shandong University
Interstitial Lung Disease (ILD)
Confocal Laser Endomicroscopy Guided Cryobiopsy in the Diagnosis of Interstitial Lung Disease
This prospective, single-center, randomized controlled trial compares pCLE-guided TBLC with conventional TBLC in patients with suspected interstitial lung disease.
- Trial name
- NCT06741826
- Testing
- pCLE-guided transbronchial lung cryobiopsy, Fluoroscopy-guided transbronchial lung cryobiopsy
- Where
- China
- Volunteers
- 430 people
- Sponsor
- China-Japan Friendship Hospital
Rectal Cancer
Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy
Currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy.
- Trial name
- NCT05316103
- Testing
- Probe-based confocal laser endomicroscopy targeted optical biopsy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Primary Sclerosing Cholangitis, Inflammatory Bowel Disease
Endomicroscopy in Primary Sclerosing Cholangitis Related Inflammatory Bowel Disease Surveillance
Evaluation of the efficacy of laser-based endomicroscopy as a complement to white-light colonoscopy and chromoendoscopy for early detection of colon dysplasia in patients with PSC-IBD.
- Trial name
- pCLE-PSC-IBD (NCT01880606)
- Testing
- colonoscopy with endomicroscopy
- Where
- Sweden
- Volunteers
- 69 people
- Sponsor
- Karolinska University Hospital
Digestive System Diseases
Confocal Laser Endomicroscopy in Digestive Diseases
Confocal laser endomicroscopy (CLE) is a newly endoscopic device that enables microscopic view of the digestive tract. The purpose of this study is to determine if confocal laser endomicroscopy can improve detection of digestive…
- Trial name
- NCT01156064
- Testing
- Confocal Laser Endomicroscopy (Pentax/Optiscan), Narrow Band Imaging/Auto Fluorescence Imaging (Olympus)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Probe-based Confocal Laser Endomicroscopy, the Operative Link on Gastric Intestinal Metaplasia
The Efficacy of Probe-based Confocal Laser Endomicroscopy in Staging OLGIM
Gastric intestinal metaplasia (GIM) is an important premalignant lesion for gastric cancer. Precisely surveillance of patients with GIM may result in early detection and improved prognosis.
- Trial name
- NCT02932735
- Volunteers
- 30 people
- Sponsor
- Shandong University
Crohn´s Disease
Endomicroscopy and Crohn´s Disease
Purpose: The main objective of this study is to determine endomicroscopic features of Crohn´s disease. Background: Crohn´s disease is an inflammatory disease of the intestines that may affect any part of the gastrointestinal…
- Trial name
- NCT01102855
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Gastric Intestinal Metaplasia
Confocal Laser Endomicroscopy With Cresyl Violet for in Vivo Diagnosis of Gastric Intestinal Metaplasia
Confocal laser endomicroscopy (CLE) is a novel endoscopic system which can provide approximately 1000-fold magnification of the gastrointestinal mucosa.
- Trial name
- NCT03672708
- Testing
- Cresyl violet
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shandong University
MALT-lymphoma
Endomicroscopy and Gastric MALT-lymphoma
Extranodal marginal zone B-cell lymphoma (MZBL) of the mucosa associated lymphoid tissue (MALT-lymphoma) represents a distinct clinical entity and is the most common form of extranodal lymphoma, with a predilection for the…
- Trial name
- NCT01583699
- Testing
- Confocal laser endomicroscopy, Confocal Laser Endomicroscope
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Barrett Syndrome, Barrett's Syndrome
CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia
This study focuses on demonstrating the value of probe-based Confocal Laser Endomicroscopy (pCLE) in guiding endoscopic therapeutic procedures in Barrett's Esophagus (BE).
- Conditions
- Barrett Syndrome, Barrett's Syndrome, Barrett's Esophagus, Barrett Esophagus
- Trial name
- CLEAN-MARGIN (NCT01032044)
- Testing
- Standard endoscopic evaluation, pCLE guided evaluation
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 164 people
- Sponsor
- Mauna Kea Technologies
Undifferentiated Gastric Cancer
Role of Probe-based Confocal Laser Endomicroscopy Targeted Biopsy in the Molecular Study of Undifferentiated Gastric Cancer
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02799420
- Testing
- GastroFlex UHD, Cellvizio; Mauna Kea Technologies, Paris, France, white light endoscopy (WLE)
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Gastric Cancer
A Pilot Study on Usefulness of Probe-based Confocal Laser Endomicroscopy Targeted Gastric Biopsy
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02089373
- Testing
- Probe-based confocal laser endomicroscopy, White light endoscopy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University