Clinical trials: Laser Endomicroscopy
Inflammatory Bowel Disease, Crohn's Disease
The Value of I-Scan and Confocal Laser Endomicroscopy for the Assessment of Chronic Inflammatory Bowel Disease
Recently, Confocal Laser Endomicroscopy (CLE) has been developed as a novel technique that actually enables in vivo microscopic analysis of the gastrointestinal tract, during ongoing endoscopy.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis, Dysplasia
- Trial name
- I-Scan-CLE-IBD (NCT02481687)
- Testing
- Confocal laser endomicroscopy
- Where
- Romania
- Volunteers
- 15 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Bladder Cancer, CLE
Confocal Laser Endomicroscopy During TransUrethral Resection for Improving BC Diagnosis and Treatment
A prospective monocenter diagnostic accuracy study of Confocal Laser Endomicroscopy (CLE) for Bladder Cancer(BC) to assess two primary objectives: 1.
- Trial name
- CLETUR (NCT05273593)
- Testing
- Confocal Laser Endomicroscopy (CLE)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Interstitial Lung Diseases
Confocal Laser Endomicroscopy and Optical Coherence Tomography for Diagnosing ILD.
Often, assessing a classifying diagnosis in patients with interstitial lung disease provides a diagnostic challenge. Currently HRCT, endoscopic or surgical video assisted thoracoscopic surgery(VATS) assessment including lung…
- Trial name
- NCT02689102
- Testing
- Probe based optical techniques
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Inflammatory Bowel Disease, Ulcerative Colitis
Assessment of Colonic Permeability by Confocal Laser Endomicroscopy
The purpose of this study is to evaluate the efficacy of confocal laser endomicroscopy in assessment of colonic permeability against conventional sugar absorption test.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Irritable Bowel Syndrome
- Trial name
- NCT00883077
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
Peripheral Pulmonary Lesions
Clinical Utility of Needle-Based Confocal Laser Endomicroscopy for Peripheral Pulmonary Lesions
This prospective, multicenter diagnostic accuracy study will evaluate the clinical utility of needle-based confocal laser endomicroscopy (nCLE) for differentiating malignant from benign peripheral pulmonary lesions (PPLs).
- Trial name
- NCT07827326
- Testing
- Confocal Laser Endomicroscopy
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Lung Cancer, Non-Small Cell, Lung Cancer, Small Cell
The Diagnostic Value of Bronchoscopic Needle-based Confocal Laser Endomicroscopy (nCLE) As a Real-time Detection Tool for Diagnosing Peripheral Lung Cancer: a Multi-centre Randomised Controlled Trial
The goal of this prospective, multi-centre, randomised controlled clinical study is to evaluate the diagnostic efficacy and safety of nCLE guided lung biopsy in patients with for peripheral lung nodules under the assistance of…
- Trial name
- NCT06739421
- Testing
- nCLE-NB-rEBUS-forcep biopsy, nCLE-NB-rEBUS-TBCB, NB-rEBUS-forcep biopsy
- Where
- China
- Volunteers
- 1,040 people
- Sponsor
- China-Japan Friendship Hospital
Irritable Bowel Syndrome, Food Sensitivity
Brachyspira and Intestinal Allergy-like Immune Reactions in Patients With Irritable Bowel Syndrome (IBS)
The aim of this study is to define local immune responses in the GI tract to food antigens in IBS patients, with and without Brachyspira infection, using advanced imaging.
- Trial name
- NCT06413004
- Testing
- Elimination and re-introduction of CLE or COLAP positive food item(s)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Magnus Simrén
Intestinal Metaplasia of Gastric Mucosa, Confocal Laser Endomicroscopy
Artificial Intelligence Confocal Laser Endomicroscopy for Real-time Assessment of Gastric Cancer Risk.
Current national guidelines recommend the use of OLGIM score to evaluate the risk of gastric cancer in patients, and close gastroscopic monitoring should be performed after OLGIM grade III/IV.
- Trial name
- NCT05459428
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shandong University
Irritable Bowel Syndrome, Food Allergy
Endomicroscopic Evaluation of Food-induced Gastrointestinal Mucosal Alteration
The overarching goal of this study is to establish a first ever registry in the U.S. to collect outcomes data to evaluate changes in the gastrointestinal (GI) mucosa following direct food application utilizing Confocal Laser…
- Trial name
- NCT06792838
- Testing
- Confocal Laser Endomicroscopy
- Volunteers
- 200 people
- Sponsor
- Cook Children's Health Care System
Irritable Bowel Syndrome, Food Sensitivity
Confocal Laser Endomicroscopy to Determine Influence of Food Antigens on Mucosal Integrity
Irritable bowel syndrome (IBS) is mainly associated with food intolerance and presents a particular challenge in gastrointestinal practice.
- Conditions
- Irritable Bowel Syndrome, Food Sensitivity, Healthy Controls
- Trial name
- RDS_CLE (NCT05056610)
- Testing
- food antigens on duodenal mucosa
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Crohn's Disease
Safety and Tolerability of FITC-Adalimumab Administration During Confocal Laser Endomicroscopy of the Gut
The scientific objective of the project is to evaluate if the topical administration of Fluoresceinisothiocyanate (FITC)-Adalimumab during the endomicroscopic examination of the gut in Crohn's disease (CD) patients shows an…
- Trial name
- FA-Crohn (NCT01275508)
- Testing
- FITC-Adalimumab
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Esophageal Squamous Intraepithelial Neoplasia
Detection of Early Esophageal Squamous Neoplasia
The aim of the present study： 1. To investigate the diagnosing value of pCLE for early esophageal squamous neoplasia. 2. To assess the detection rate of early esophageal squamous neoplasia by virtual chromoendoscopy
- Trial name
- NCT01909518
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shandong University
Pancreatic Cancer, Diagnosis
The Application of Probe Confocal Laser Endomicroscopy in Pancreatic Tumor Surgery
Aim of the study: To evaluate the value of Probe Confocal Laser Endomicroscopy (PCLE) in surgery for pancreatic tumor. Methods: Patients who are diagnosed with pancreatic tumor based on preoperative radiographic findings and will…
- Conditions
- Pancreatic Cancer, Diagnosis, Pancreatoduodenectomy, Distal Pancreatectomy
- Trial name
- NCT06289803
- Testing
- probe confocal laser endomicroscopy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Low Grade Intraepithelial Neoplasia, High Grade Intraepithelial Neoplasia
Comparison of pCLE and EB in Gastric Lesion Diagnosis
This is a prospective multicenter comparative study, aiming to compare probe-based confocal laser endomicroscopy (pCLE) and endoscopic biopsies in the diagnosis of the whole specific gastric lesion especially for distinguishing…
- Conditions
- Low Grade Intraepithelial Neoplasia, High Grade Intraepithelial Neoplasia, Early Gastric Cancer, Gastric Intraepithelial Neoplasia
- Trial name
- NCT06389448
- Testing
- pCLE-gastr
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Huazhong University of Science and Technology
Lung Cancer, Lung Neoplasm Malignant
Confocal Laser Endomicroscopy VERification
The goal of this multi-center randomized clinical trial is to evaluate the added value of needle based confocal laser endomicroscopy (nCLE)-imaging to regular diagnostic bronchoscopic peripheral lung lesion analysis on the…
- Conditions
- Lung Cancer, Lung Neoplasm Malignant, Carcinoma, Non-Small-Cell Lung, Neoplasm of Lung
- Trial name
- CLEVER (NCT06079970)
- Testing
- Neelde Based Confocal Laser Endomicroscopy, Conventional diagnostic bronchoscopy
- Where
- 5 sites in United States, Austria and 3 more
- Volunteers
- 208 people
- Sponsor
- Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Cystic Tumors of Pancreas
Clinical Evaluation Of Needle-based Confocal Laser Endomicroscopy in Cystic Tumors of the Pancreas
This study focuses on pancreatic cysts, especially malignant pancreatic cysts. The primary hypothesis of the study is that using nCLE in addition to EUS-FNA and tissue sampling allows better characterization of pancreatic cysts…
- Trial name
- NCT03182270
- Testing
- nCLE
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital