Clinical trials: Laser in Situ Keratomileusis
Myopia, Astigmatism
Randomized, Prospective Comparison of the Outcome of Toric Implantable Contact Lens (TICL) and Q-LASIK for the Correction of Myopia With Astigmatism
The objective is to conduct a contralateral prospective clinical study to compare the safety, efficacy, and quality of vision of the STAAR Surgical Co.
- Trial name
- NCT01088568
- Testing
- the implantation of toric implantable collamer lens, customized laser-assisted in situ keratomileusis
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Hyperopia
Safety and Effectiveness of the TENEO 317 Model 2 (1.28 US) Excimer Laser for Laser In Situ Keratomileusis (LASIK) Surgery to Treat Hyperopia With or Without Astigmatism
This will be a multicenter, prospective, open label, non-randomized, single arm 12 month study, evaluating the safety and effectiveness of the TECHNOLAS TENEO 317 Model 2 (Software version "1.28 US") excimer laser when used in…
- Trial name
- NCT05264623
- Testing
- TENEO 317 Model 2 excimer laser
- Where
- 9 sites in United States
- Volunteers
- 140 people
- Sponsor
- Bausch & Lomb Incorporated
Keratomileusis, Laser In Situ
The Role of Psychosocial and Other Quality of Life Parameters in Evaluating Functional Changes Prior to and Following Laser In-situ Keratomileusis (LASIK)Changes Laser In-situ Keratomileusis (LASIK)
To evaluate the changes in quality of life parameters after LASIK surgery.
- Trial name
- NCT00344604
- Testing
- Role of psychosocial and quality of life parameters prior to and following LASIK.
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Myopia, Astigmatism
Changes Between Lenticule Extraction and Femtosecond Laser-assisted Laser in Situ Keratomileusis
The aim is to evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (FLEx) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) procedures.
- Trial name
- NCT02550353
- Testing
- lenticule extraction, femtosecond laser-assisted laser in situ keratomileusis
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Keratomileusis, Laser In Situ
Mechanical vs. Alcohol Separation of the Corneal Epithelium During Surface Ablation Refractive Procedures
A recent survey of trends among the members of the American Society of Cataract and Refractive Surgery determined that laser in situ keratomileusis (LASIK) is the leading surgical procedure for photorefractive corrections ranging…
- Trial name
- NCT00366808
- Testing
- LASIK surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
FS-LASIK Surgery Effect on Higher Order Aberrations
Contribution of SA and Coma to The Total Ocular HOA Before and After FS-LASIK Using An Aspheric Ablation Profile
Laser-assisted in situ keratomileusis (LASIK) is the most frequently performed refractive surgery procedure for the correction of myopia, hyperopia, and astigmatism.
- Trial name
- NCT04966806
- Testing
- LASIK refractive surgery
- Where
- Egypt
- Volunteers
- 17 people
- Sponsor
- Kasr El Aini Hospital
Myopia, Astigmatism
Randomized, Non-inferiority Trial Comparing SMILE and LASIK
Background: Small Incision Lenticule Extraction or SMILE is a novel form of 'flapless' corneal refractive surgery that was adapted from Refractive Lenticule Extraction (ReLEx).
- Conditions
- Myopia, Astigmatism, Hypermetropia
- Trial name
- NCT01216475
- Testing
- Femtosecond LASIK, Small incision lenticule extraction (SMILE)
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Refractive Surgery
Analysis of Ocular Surface Microbiota in Dry Eye Patients After Femtosecond Laser-assisted In-situ Keratomileusis (FS-LASIK)
By using 16S rRNA sequencing technology to analyze the changes in ocular surface microbiota before and after surgery, as well as the impact of changes in ocular surface microbiota on FS-LASIK induced DES, new treatment ideas are…
- Trial name
- NCT06448468
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Chronic Ocular Pain
Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)
The study was designed to demonstrate the safety and efficacy of two dose concentrations of SAF312 eye drops (5 mg/mL and 15 mg/mL) in subjects with CICP persisting at least for 4 months after refractive or cataract surgery and…
- Trial name
- NCT04630158
- Testing
- SAF312
- Where
- 28 sites in United States, Japan and 1 more
- Volunteers
- 153 people
- Sponsor
- Novartis Pharmaceuticals
Laser in Situ Keratomileusis
Patient Reported Outcomes With LASIK: PROWL-2
This study evaluates a questionaire designed to measure satisfaction and ophthalmic-related quality of life (QoL) of 300 civilian participants prior to and three months following state-of-the-art laser in situ keratomileusis…
- Trial name
- PROWL-2 (NCT01655420)
- Testing
- LASIK
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- Food and Drug Administration (FDA)
Myopic Regression
Effect of Timolol on Refractive Outcomes in Eyes With Myopic Regression After LASIK: a Randomized Clinical Trial
In this randomized controlled clinical trial, we compare the effects of timolol versus placebo for treatment of myopic regression after LASIK
- Trial name
- NCT01506635
- Testing
- Timolol
- Where
- Iran
- Volunteers
- 45 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Dry Eye
Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?
Can Lyrica (Pregabalin) help prevent severe Dry Eye post LASIK surgery?
- Trial name
- NCT02701764
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Miami
Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG)
A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases
The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.
- Conditions
- Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG), Dry Eye Disease (DED), Keratoconus
- Trial name
- NCT07780890
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lasik Eye Surgery
Long-term LASIK Follow up Study
Laser in situ keratomileusis (LASIK) is the most common corneal refractive surgery performed for correction of myopia. There are very few studies that have been performed to evaluate long-term outcomes after LASIK.
- Trial name
- LASIK (NCT01695642)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Michigan
Dry Eye, Dry Eye After LASIK-Laser in Situ Keratomileusis
Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery
Laser corneal refractive surgery is a widely adopted approach for correcting refractive errors, but postoperative dry eye remains a common side effect.
- Trial name
- TEBELID (NCT05803798)
- Testing
- IPL+LLLT
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Tomography, Corneal Biomechanics
Long-term Safety and Effectiveness of LASIK-Xtra Compared to Conventional LASIK
Laser in situ keratomileusis (LASIK) is a widely used procedure for the correction of myopia and myopic astigmatism. Despite its high effectiveness and the general safety of the procedure, long-term safety and effectiveness…
- Conditions
- Tomography, Corneal Biomechanics, Manifest Ref, Endothelial Cells
- Trial name
- Xtra Lasik (NCT06857032)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Clinic Frankfurt
Dry Eye Disease
Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Laser-assisted in Situ Keratomileusis (LASIK)
Evaluate the safety and effectiveness of OC-01 (varenicline) nasal spray for amelioration of signs and symptoms of dry eye disease in subjects following laser-assisted in situ keratomileusis (LASIK).
- Trial name
- NCT05082974
- Testing
- OC-01 (varenicline 0.6mg/ml) nasal spray
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision ND
Myopia
Comparison of LASIK and SBK
The objective of the study is to compare clinical outcomes from LASIK and SBK using FDA-approved laser technology on the same patient
- Trial name
- NCT00714363
- Testing
- LASIK, SBK
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Mixed Astigmatism
Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Mixed Astigmatism
The purpose of this study is to determine whether the MEL 80 Excimer Laser is effective in the treatment of mixed astigmatism up to 6.0 D, when used as part of the Laser In Situ Keratomileusis (LASIK) procedure.
- Trial name
- NCT00761826
- Testing
- MEL 80 Mixed Astigmatism Treatment
- Where
- 5 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt