Clinical trials: Laser in Situ Keratomileusis
Refractive Surgery
CONTOURA vs WFO Ablation PRK & LASIK
This is a prospective randomized contralateral double-masked study. Each patient will be randomized as to which eye undergoes wave-front optimized (WFO) vs.
- Trial name
- NCT05037370
- Testing
- Wave-Front Optimized (WFO) ablation vs Topography-guided (TG) ablation
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Refractive Surgery
Comparison of Outcomes Between TransPRK and Off-flap Epi-LASIK
To compare the quantitative and qualitative optical outcomes between single-step transepithelial photorefractive keratectomy (TransPRK) and off-flap epipolis laser in situ keratomileusis (Epi-LASIK) in moderate to high myopia.we…
- Trial name
- NCT05060094
- Volunteers
- 38 people
- Sponsor
- Wenzhou Medical University
Myopia, Astigmatism
Randomized, Prospective Comparison of the Outcome of Toric Implantable Contact Lens (TICL) and Q-LASIK for the Correction of Myopia With Astigmatism
The objective is to conduct a contralateral prospective clinical study to compare the safety, efficacy, and quality of vision of the STAAR Surgical Co.
- Trial name
- NCT01088568
- Testing
- the implantation of toric implantable collamer lens, customized laser-assisted in situ keratomileusis
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Myopic Regression
Effect of Timolol on Refractive Outcomes in Eyes With Myopic Regression After LASIK: a Randomized Clinical Trial
In this randomized controlled clinical trial, we compare the effects of timolol versus placebo for treatment of myopic regression after LASIK
- Trial name
- NCT01506635
- Testing
- Timolol
- Where
- Iran
- Volunteers
- 45 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Surgery, Myopia
Topo-guided LASIK and Photorefractive Keratectomy vs Wavefront LASIK and Photorefractive Keratectomy
This study evaluates the difference in results between eyes that have been treated wavefront optimized laser vision correction (either LASIK or Photorefractive Keratectomy) compared to eyes treated with topography-guided laser…
- Trial name
- NCT03075176
- Testing
- Wavefront optimized LASIK, Wavefront optimized Photorefractive Keratectomy, Topography-guided LASIK
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Utah
Myopic Astigmatism
A Study to Investigate the Safety and Effectiveness of the Technolas® TENEO 317 Model 2 Excimer Laser for Laser In Situ Keratomileusis (LASIK) Surgery to Treat Myopia or Myopic Astigmatism
This will be a multicenter, prospective, open label, non-randomized, single arm study evaluating the safety and effectiveness of the Technolas® TENEO 317 Model 2 (version 1.28 US software) Excimer Laser when used in LASIK surgery…
- Trial name
- NCT07377474
- Testing
- TENEO 317 Model 2 (1.28 US) Excimer Laser
- Volunteers
- 32 people
- Sponsor
- Bausch & Lomb Incorporated
Lasik Eye Surgery
Assessment of the Preoperative Risk Factors for the Development of Post-LASIK Ectasia
: Laser-assisted in situ keratomileusis (LASIK) is one of the most widely performed refractive surgeries, offering effective and long-lasting correction for visual refractive errors.
- Trial name
- NCT06806306
- Testing
- LASIK
- Volunteers
- 13 people
- Sponsor
- Al-Azhar University
Myopia
Optical Coherence Pachymetry to Evaluate Central Corneal Ablation Depth in Myopic Femtosecond Laser in Situ Keratomileusis
Prospective study aiming to measure central ablation depth during excimer laser surgery in myopic patients operated with femtosecond laser assisted LASIK with intraoperative OCP, before and after laser ablation.
- Trial name
- PACO (NCT02893644)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Tomography, Corneal Biomechanics
Long-term Safety and Effectiveness of LASIK-Xtra Compared to Conventional LASIK
Laser in situ keratomileusis (LASIK) is a widely used procedure for the correction of myopia and myopic astigmatism. Despite its high effectiveness and the general safety of the procedure, long-term safety and effectiveness…
- Conditions
- Tomography, Corneal Biomechanics, Manifest Ref, Endothelial Cells
- Trial name
- Xtra Lasik (NCT06857032)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Clinic Frankfurt
Dry Eye
Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?
Can Lyrica (Pregabalin) help prevent severe Dry Eye post LASIK surgery?
- Trial name
- NCT02701764
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Miami
Myopia, Astigmatism
Z8 OCT-controlled 2D vs 3D LASIK
The aim of this study was to test the hypothesis that OCT-guided 110 µm targeted flaps will result in accurate, predictable, and precise thickness flaps, with low complication rates when performed and compared using both 2D and…
- Trial name
- NCT04426175
- Testing
- 2D and 3D cutting method using a low energy Femtosecond laser LDV Z8 for LASIK flap cutting
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Zentrumsehstarke Hamburg
Myopia
Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Moderate to High Myopia
The purpose of this study is to determine whether the MEL 80 Excimer Laser is effective in the treatment of moderate to high myopia (nearsightedness), when used as part of the Laser In Situ Keratomileusis (LASIK) procedure.
- Trial name
- NCT00762541
- Testing
- MEL 80 Treatment of High Myopia
- Where
- 5 sites in United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Nearsightedness, Farsightedness
Advanced Surface Ablation (ASA) vs Laser-Assisted In Situ Keratomileusis (LASIK)
The purpose of this combined retrospective and prospective chart review analysis is to investigate the safety, efficacy, and predictability obtained via Laser-Assisted In Situ Keratomileusis (LASIK) and Advanced Surface Ablation…
- Conditions
- Nearsightedness, Farsightedness, Astigmatism
- Trial name
- NCT00778570
- Where
- Canada
- Volunteers
- 4,000 people
- Sponsor
- Ottawa Hospital Research Institute
Myopia, Astigmatism
Changes Between Lenticule Extraction and Femtosecond Laser-assisted Laser in Situ Keratomileusis
The aim is to evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (FLEx) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) procedures.
- Trial name
- NCT02550353
- Testing
- lenticule extraction, femtosecond laser-assisted laser in situ keratomileusis
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Laser in Situ Keratomileusis
Patient-Reported Outcomes With LASIK:PROWL-1
This study evaluates a questionnaire designed to measure satisfaction and ophthalmic-related quality of life (QOL)in up to 550 active duty subjects prior to and six months following state-of-the-art laser in situ keratomileusis…
- Trial name
- PROWL-1 (NCT01526291)
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Food and Drug Administration (FDA)
Keratomileusis, Laser In Situ
Mechanical vs. Alcohol Separation of the Corneal Epithelium During Surface Ablation Refractive Procedures
A recent survey of trends among the members of the American Society of Cataract and Refractive Surgery determined that laser in situ keratomileusis (LASIK) is the leading surgical procedure for photorefractive corrections ranging…
- Trial name
- NCT00366808
- Testing
- LASIK surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Refractive Errors
Anxiety-related Fixation Instability During LASIK
Anxiety is common among patients undergoing eye surgery, which is typically performed under topical anesthesia while the patient is awake.
- Trial name
- NCT06148428
- Testing
- Laser in situ keratomileusis (LASIK)
- Where
- Egypt
- Volunteers
- 2,435 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myopic LASIK Candidates With Spherical Equivalent up to - 10 Diopters
Thin-Flap Laser in Situ Keratomileusis Associated Dry Eye
Laser in situ keratomileusis (LASIK) eye surgery continues to be the most common refractive procedure used to correct different forms of ametropia.
- Trial name
- NCT04831177
- Testing
- Laser in situ keratomileusis
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Assiut University
FS-LASIK Surgery Effect on Higher Order Aberrations
Contribution of SA and Coma to The Total Ocular HOA Before and After FS-LASIK Using An Aspheric Ablation Profile
Laser-assisted in situ keratomileusis (LASIK) is the most frequently performed refractive surgery procedure for the correction of myopia, hyperopia, and astigmatism.
- Trial name
- NCT04966806
- Testing
- LASIK refractive surgery
- Where
- Egypt
- Volunteers
- 17 people
- Sponsor
- Kasr El Aini Hospital
Refractive Errors
Changes in Angle Kappa and Corneal Back Elevations After Laser in Situ Keratomileusis in Myopic Astigmatism
Refractive errors and corneal astigmatism are associated with changes in angle kappa and corneal back elevation at the thinnest point in Pentacam.
- Trial name
- NCT06166212
- Volunteers
- 50 people
- Sponsor
- Ain Shams University