Clinical trials: Lasers
Apical Periodontitis, Post Operative Pain, Acute
Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation
When a tooth's nerve dies, inflammation can develop at the tip of the tooth's root. Root canal treatment is carried out to allow this inflammation to heal.
- Trial name
- NCT07883486
- Testing
- sonically activated irrigation, laser activated irrigation, conventional needle irrigation
- Where
- 2 sites in Belgium
- Volunteers
- 183 people
- Sponsor
- University Ghent
Post Menopausal Vaginal Atrophy
Efficacy of Fractional CO2 Laser Treatment in Post-Menopausal Women With Vaginal Atrophy
Vaginal dryness, itching, burning, irritability, secretion, and various urinary problems are the symptoms of vulvovaginal atrophy.
- Trial name
- NCT06726746
- Testing
- Fractional CO2 laser
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Carpal Tunnel Syndrome, Entrapment Neuropathy
High Intensity Laser Therapy in Carpal Tunnel Syndrome
This research aims to investigate the effect of high-intensity laser therapy on pain, function, nerve conduction studies and grip strength in patients with idiopathic carpal tunnel syndrome.
- Conditions
- Carpal Tunnel Syndrome, Entrapment Neuropathy, Median Neuropathy, Musculoskeletal Diseases
- Trial name
- NCT04949373
- Testing
- High-intensity laser therapy (HILT)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Afyonkarahisar Health Sciences University
Tattoo, Acne Keloidalis Nuchae
7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream
The purpose of this study is to compare the efficacy of 7% lidocaine / 7% tetracaine cream and 2,5% lidocaine / 2,5% prilocaine cream in reducing self-reported pain during a single laser procedure in the treatment of acne…
- Trial name
- OPTICA (NCT02372786)
- Testing
- 2,5% lidocaine / 2,5% prilocaine cream, 7% lidocaine / 7% tetracaine cream, Neodymium-doped yttrium aluminium garnet (Nd:Yag) laser
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Burn Scar
The Role of Fractional Vascular Laser Therapy in the Management of Burn Scars
While the literature tends to support the use of laser therapy in the management of burn scars, there is a definite lack of appropriately powered, randomized controlled trials.
- Trial name
- NCT01619917
- Testing
- Fractional Vascular Laser
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Manitoba
Chronic Periodontitis
Photodynamic Therapy Associated With Full-mouth Ultrasonic Debridement in the Treatment of Severe Chronic Periodontitis
Background: Photodynamic therapy (PDT) is a method of microbial reduction which can benefit periodontal treatment in areas of difficult access, such as deep pockets and furcations.
- Trial name
- NCT01535690
- Testing
- photodynamic therapy and periodontal debridement
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Escola Bahiana de Medicina e Saude Publica
Photodynamic Therapy& Low Level Laser in Management of COVID 19
Photodynamic Therapy for the Treatment of COVID-19
Until now there is no vaccine or reliable treatment for the COVID-19 pandemic. The fundamental mechanisms of non-invasive low-level laser in photobiomodulation (PBM) and photodynamic therapy is to stimulate the mitochondrial…
- Trial name
- NCT04416113
- Testing
- photobiomodulation and photodynamic therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Pigmentation, Gingiva
Post Gingival Depigmentation Assessment: Comparison of Surgical Stripping vs (Er,Cr:YSGG) Laser
The appearance and health of the gingiva significantly contribute to an aesthetically pleasing smile. Pink gingiva indicates healthy gums and is generally preferred over dark or mixed colors.
- Trial name
- NCT06075641
- Testing
- Gingival depigmentation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Osteoarthritis (OA) of the Knee, Osteoarthitis
Effect of High-Intensity Laser Therapy on Femoral Cartilage in Knee Osteoarthritis
This clinical trial will evaluate the effects of High-Intensity Laser Therapy (HILT) on femoral cartilage thickness and other clinical outcomes in people with knee osteoarthritis.
- Trial name
- HILT-KOA (NCT07584603)
- Testing
- High-Intensity Laser Therapy (HILT) + Conventional Physiotherapy, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- University of Lahore
Class II Division 1 Malocclusion
Effect of Low-level Laser Therapy During Maxillary Molar Distalization Using a Skeletally Anchored Appliance
study will be directed to evaluate the effect of low-level laser therapy during maxillary molar distalization using a skeletally anchored appliance
- Trial name
- NCT05465473
- Testing
- Distalization
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Osteoporosis, Postmenopausal, Osteopenia
High-Intensity Laser Therapy and Physiotherapy for Bone Health in Postmenopausal Women: A Randomized Trial
The goal of this clinical trial is to learn if adding high-intensity laser therapy (HILT) to a physiotherapy programme helps bone health in women after menopause who have low bone density (osteopenia or osteoporosis).
- Trial name
- NCT07734922
- Testing
- High-Intensity Laser Therapy, Standardised Physiotherapy Programme
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Lateral Epicondylitis
Lateral Epicondylitis Treatment High Intensive Laser Therapy and Extracorporeal Shock Wave Therapy
Objectives: This study aims to evaluate and compare the short-term efficacy of high-intensity laser therapy (HILT) and extra corporeal shock wave therapy(ESWT) on pain, sensitivity, handgrip strength, and functions in the…
- Trial name
- NCT06301152
- Testing
- high intensive laser, extracorporeal shock wave therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Cataract
Cytokines in Femtosecond Laser-assisted Cataract Surgery
The investigators performed the current study to compare: 1) the pain scores by Visual Analogue Scale; 2) the cytokines concentrations in aqueous humor by human cytokine antibody array; 3) the prostaglandin E2 (PGE2)…
- Trial name
- NCT05511506
- Testing
- aqueous humor collection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pain During and After Endovenous Laser Obliteration of Large Saphenous Vein Based on Lidocaine Tumescent Concentration
Efficacy of Variable Lidocaine Concentrations in Tumescent Anesthesia for Pain Control During and After Endovenous Laser Procedure; Non-inferiority Trial
Endovenous laser treatment is a minimally invasive procedure that has been shown to be a safe and effective treatment for varicose veins.
- Trial name
- NCT02192411
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Midwest Vein Center
Corneal Astigmatism
Manually Performed Limbal Relaxing Incisions vs Femtosecond Laser-guided Astigmatic Keratotomy
Astigmatic keratotomy (AK) is used to treat numerous refractive disorders, including congenital astigmatism, residual corneal astigmatism at the time of or following cataract surgery, post-traumatic astigmatism, and astigmatism…
- Trial name
- NCT03264534
- Testing
- limbal relaxing incisions, astigmatic keratotomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Hepatocellular Carcinoma
Neoadjuvant Sorafenib Therapy Prior to Laser Ablation for Hepatocellular Carcinoma
The purpose of this study is to determine whether neoadiuvant therapy with sorafenib increases the efficacy of thermal ablation in inducing the necrosis of hepatocellular carcinoma.
- Trial name
- LANEX (NCT01507064)
- Testing
- Sorafenib, laser ablation (LA)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Cardarelli Hospital
Hemorrhoids Second Degree, Hemorrhoids Third Degree
Comparison of Laser Hemorrhoidoplasty Versus Conventional Milligan Morgan Hemorrhoidectomy in Grade II and III Hemorrhoids
Hemorrhoidal disease is one of the most common anorectal disorders. Conventional Milligan Morgan Hemorrhoidectomy remains the standard treatment but is associated with considerable postoperative pain.
- Conditions
- Hemorrhoids Second Degree, Hemorrhoids Third Degree, Internal Hemorrhoids
- Trial name
- LHP-MMH (NCT07678814)
- Testing
- Laser Hemorrhoidoplasty, Milligan Morgan Hemorrhoidectomy
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Allama Iqbal Medical College
Cataract
Economic Evaluation of Femtosecond Laser Assisted Cataract Surgery
Cataract is the leading cause of blindness worldwide and cataract surgery is the most frequent surgery performed in France. A new technology, the femtosecond laser-assisted cataract surgery, has to be compared with…
- Trial name
- FEMCAT (NCT01982006)
- Testing
- Cataract surgery with Phacoemulsification, Femtosecond laser-assisted cataract surgery
- Where
- 5 sites in France
- Volunteers
- 920 people
- Sponsor
- University Hospital, Bordeaux
Hand-Foot Syndrome
The Efficacy of Acupuncture and Laser Acupuncture in Treating Chemotherapy or Target Therapy-induced Hand-foot Syndrome
Chemotherapy or target therapy-induced hand-foot syndrome in cancer patients affects the quality of life. At present, there is no better treatment for this side effect of chemotherapy or target therapy.
- Trial name
- NCT05949307
- Testing
- acupuncture, laser acupuncture
- Volunteers
- 60 people
- Sponsor
- China Medical University Hospital
Retinopathy of Prematurity
European Disease Registry on Retinopathy of Prematurity (ROP)
The EU-ROP registry is a European wide multicenter non-interventional observational registry study intended to run open-ended in as many countries as possible including infants treated for retinopathy of prematurity irrespective…
- Trial name
- EU-ROP (NCT04939571)
- Testing
- Registry of preterm born infants with treatment-requiring ROP
- Where
- 59 sites in Austria, Bulgaria and 10 more
- Volunteers
- 3,000 people
- Sponsor
- University Medicine Greifswald
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