Clinical trials: Late Effects
Stroke, Hemiparesis
Late LTP-like Plasticity Effects of tDCS in Subacute Stroke Patients
Rationale: About 80% of stroke patients suffer motor impairments, but current therapies have limited effects on motor recovery. Therefore, investigating new potential therapeutic approaches is crucial.
- Trial name
- NCT02393651
- Testing
- tDCS
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Erasmus Medical Center
Female Infertility, Female Subfertility
Effects of Recombinant LH in Patients With Repeated Implantation Failure
Pregnancy rates fall dramatically in women after 35 years undergoing to IVF or ICSI. While ovarian aging obviously plays the major role in this phenomenon, over suppression of endogenous LH concentrations with GnRH agonists or…
- Trial name
- late-rLH (NCT03204253)
- Testing
- rFSH + r-LH in combination, rFSH alone
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Postoperative Nausea and Vomiting, Breast Cancer Female
Ramosetron on Late PONV (Postoperative Nausea and Vomiting)
The purpose of this study was to evaluate the effectiveness of additional ramosetron injection for controlling late postoperative nausea and vomiting (PONV) after breast surgery in high risk PONV patients.
- Trial name
- NCT05326360
- Testing
- Ramosetron Hydrochloride
- Where
- South Korea
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Ebola Virus Disease
Natural History, Disease Progression, and Long-Term Neurologic Sequelae of Ebola Virus Disease (EVD) Survivors in PREVAIL III
Background: Ebola virus disease (EVD) is a viral fever that can cause internal bleeding. The death rate from EVD is very high. In a 2014 outbreak in West Africa, 28,000 were affected and 11,000 died.
- Trial name
- NCT05494801
- Where
- Liberia
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Cancer
Effect of Early vs Late Drainage Removal in Women After Radical Mastectomy With Axillary Clearance
The aim of the study is to assess whether early drainage removal in patients with less than 150ml of lymph in postoperative day 1 can reduce total lymphorrhoea
- Trial name
- CHLONKA (NCT01221064)
- Testing
- Early drainage removal, Late drainage removal
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
Distal Amputation of the Fingers
Lipofilling Versus Conservative Treatment in Fingertips Injuries Sequelae
The purpose of this study is to evaluate the contribution of autologous graft reinjection (lipofilling) in the treatment of dysaesthesic pulp.
- Trial name
- LIPOFILLING (NCT04076397)
- Testing
- autologous transplant reinjection, desensitization
- Where
- 2 sites in France
- Sponsor
- University Hospital, Brest
Brain Tumors
Working Memory Performance Among Childhood Brain Tumor Survivors
Children treated with radiation therapy for brain tumors are at risk for cognitive problems. These problems have typically been demonstrated on global cognitive measures including measures of intellectual functioning (IQ).
- Trial name
- NCT00693914
- Testing
- Series of tests/questionnaires
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Renal Failure, Left Ventricular Hypertrophy
Attenuation of Cardiac Effects of Arteriovenous Fistula Creation With Losartan
The primary objective is to determine if the use of losartan, an angiotensin II receptor blocker, can attenuate left ventricular hypertrophy, independent of its antihypertensive effects, in patients with near end stage chronic…
- Trial name
- NCT00602004
- Testing
- losartan
- Where
- Australia
- Volunteers
- 52 people
- Sponsor
- Melbourne Health
Stroke, Spasticity as Sequela of Stroke
Radial Extracorporeal Shock Wave Therapy as an Adjunct to Botulinum Toxin Type A for Post-Stroke Lower Limb Spasticity (SOLUTION)
The goal of this pilot clinical trial is to determine whether radial extracorporeal shock wave therapy (rESWT), when used as an adjunct to ultrasound-guided botulinum toxin type A (BoNT-A) injections, can enhance the therapeutic…
- Conditions
- Stroke, Spasticity as Sequela of Stroke, Lower Limb Spasticity, Upper Motor Neuron Syndrome
- Trial name
- SOLUTION (NCT07875868)
- Testing
- Radial shock Wave therapy (3000 pulses, 5 Hz, 2.5 bar)., Ultrasound-guided abobotulinumtoxin A
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Parc de Salut Mar
Anemia
Effect of Maternal Hemoglobin on Neurobehavioural Development of Late Preterm Neonates : A Cohort Study
The study entitled 'Effect of maternal hemoglobin on neurobehavioral development of late preterm neonates' was done with an objective to determine whether low maternal hemoglobin (<11gm/dl), in late preterm neonates(>34weeks but…
- Trial name
- NCT02840292
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Lady Hardinge Medical College
Premature Infant
Psychomotor Therapy for Very Premature Infants
Our current reflexion is that sensory dys-stimulations, including vestibule-proprioceptive disorders and unbalanced between brain and brainstem maturation of the neonatal period involve an early deviant development for immature…
- Trial name
- VPI (NCT03093337)
- Testing
- Early post hospital discharge psychomotor therapy
- Where
- 10 sites in France
- Volunteers
- 162 people
- Sponsor
- University Hospital, Toulouse
Brain Injury, Sequelae
Hyperbaric Oxygen Therapy in Chronic Stable Brain Injury
The purpose of this study is to discover the feasibility of conducting clinical research in individuals with chronic sequelae following brain injury who are given hyperbaric oxygen.
- Conditions
- Brain Injury, Sequelae, Stroke, Anoxia
- Trial name
- HYBOBI (NCT00830453)
- Testing
- Hyperbaric oxygen therapy (HBO2)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Intermountain Health Care, Inc.
Testicular Cancer
TACkLE Study - Tackling Adverse Chemotherapy-associated Late Effects
Testicular cancer (TC) is a rare disease, which mostly affects young men aged 15-35 years. Their life expectancy has greatly improved due to the introduction of platinum-containing chemotherapy for disseminated TC in the late…
- Trial name
- TACkLE (NCT02276430)
- Testing
- Vena punction
- Where
- 3 sites in Netherlands
- Volunteers
- 939 people
- Sponsor
- University Medical Center Groningen
Cerebral Hemorrhage
Human Umbilical Cord Mesenchymal Stem Cell in Cerebral Hemorrhage Sequela
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for cerebral hemorrhage sequela.
- Trial name
- NCT02283879
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Stroke Sequelae, Stroke
Multiple Dose Study to Evaluate Drug-drug Interactions, Safety and Tolerability of NDC-002 in Healthy Volunteers
An Open-label, One-sequence, Three-period, Multiple-dose Study to Evaluate Drug-drug Interactions, Safety and Tolerability between NDC-002A/NDC-002B and NDC-002C in Healthy Volunteers
- Trial name
- NCT06090474
- Testing
- NDC-002
- Where
- South Korea
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Dr. Noah Biotech Inc.
Post Acute COVID-19 Syndrome, Long COVID
Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Long COVID
The main purpose of this study is to gather data and assess changes in patient-reported outcomes with the stellate ganglion blocks as treatment for their sympathetically-mediated long COVID symptoms.
- Conditions
- Post Acute COVID-19 Syndrome, Long COVID, Long Covid19, COVID-19 Recurrent
- Trial name
- DSBLongCOVID (NCT05638620)
- Testing
- stellate ganglion block with 0.5% bupivacaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jonathann Kuo, MD
Ischemic Stroke
Radial Shock Waves for Functional Disability in Stroke
This is a double blind randomized clinical trial to evaluate the effect of radial shock waves on functional recovery of the upper limb of patients with sequelae of ischemic strokes in the territory of the middle cerebral artery.
- Trial name
- NCT02924168
- Testing
- Active Radial Shockwave
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Marta Imamura
Stroke, Ischemic, Stroke, Acute
Efficacy of Cerebrolysin Treatment as an add-on Therapy to Mechanical Thrombectomy in Acute Ischemic Stroke.
This study is designed to determine the efficacy and safety of Cerebrolysin treatment as an add- on therapy to mechanical thrombectomy (MT) in reducing global disability in subjects with acute ischemic stroke (AIS).
- Conditions
- Stroke, Ischemic, Stroke, Acute, Stroke Sequelae
- Trial name
- NCT04904341
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Military Institute od Medicine National Research Institute
Cranial Nerve Injury, Oropharyngeal Cancer
Proactively Intervening On Early Cranial Nerve Injury As A Delayed Sequela Of Oropharyngeal Cancer: A Randomized Feasibility Clinical Trial For Pro-Habilitation (proNERVE RCT)
The goal of this clinical research study is to learn about possible intervention strategies to help control cranial neuropathy in patients after they receive radiation therapy for OPC.
- Trial name
- NCT07832266
- Testing
- Prednisone, Ajovy, Manual Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- M.D. Anderson Cancer Center
Hand Flexor Tendon, Facial Mobilization
Effect of Myofascial Release on Pain, Grip Strength, Manual Dexterity, and Quality of Life in Late-Term Rehabilitation of Hand Flexor Tendon Repairs
The aim of this study was to investigate the effectiveness of myofascial release exercises performed in the late period compared to classical physiotherapy training in individuals with hand flexor tendon repair.
- Conditions
- Hand Flexor Tendon, Facial Mobilization, Exercise
- Trial name
- NCT07233369
- Testing
- Fascial mobilization therapy, conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University