Clinical trials: Late Effects, active
Cancer, Cancer in Pregnancy
ProspectiveFemaleAYA - Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, the evidence-based knowledge on the prevalence and risk factors for gonads impairment, including infertility, following cancer and numerous cancer treatment regimen has significantly increased.
- Conditions
- Cancer, Cancer in Pregnancy, Infertility, In Vitro Fertilisation (IVF) Treatment
- Trial name
- FemFertilAYA (NCT07622420)
- Volunteers
- 3,000 people
- Sponsor
- Karolinska Institutet
Nursing Education, Simulation of Physical Illness
Moulage Technique in Child Abuse Recognition
Early recognition of physical abuse in children is essential for ensuring child safety and preventing further harm. However, distinguishing abuse-related injuries from accidental findings can be challenging, especially for…
- Conditions
- Nursing Education, Simulation of Physical Illness, Child Physical Abuse, Suspected, Sequela
- Trial name
- Moulage (NCT07509723)
- Testing
- Moulage Technique Group, movie group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Atlas University
Tuberculosis, Pulmonary
Post TB Sequelae Study
The goal of this prospective cohort study is to learn about the long-term health effects of tuberculosis (TB) in children, adolescents, and adults who have completed standard TB treatment in Bangladesh.
- Trial name
- NCT06744179
- Testing
- echocardiography, chest x-ray, full blood count , SGPT, lipid profile, HbA1C, AQ20 questionnaire, mmRC dyspnoea scale, Duke activity status index, COPD assessment test, Age and stage questionnaire
- Where
- Bangladesh
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Postoperative Pain, Facial Swelling
Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery
This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of…
- Conditions
- Postoperative Pain, Facial Swelling, Trismus
- Trial name
- Reparil (NCT07244029)
- Testing
- Escin, Ibuprofen 400 mg
- Where
- Oman
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oman Medical Speciality Board
Breast Cancer, Breast Cancer Female
Effectiveness of Personalized Surveillance and Aftercare for Breast Cancer
Surveillance and aftercare for curatively treated primary breast cancer patients is currently mostly 'one-size-fits-all', but can be personalized based on patients' risk of recurrence (depending on patient-, tumor- and…
- Conditions
- Breast Cancer, Breast Cancer Female, Survivorship
- Trial name
- NABOR (NCT05975437)
- Testing
- personalized surveillance plans (PSP) and personalized aftercare plans (PAP)
- Where
- 10 sites in Netherlands
- Volunteers
- 1,040 people
- Sponsor
- Comprehensive Cancer Centre The Netherlands
Sleep Quality
The Effect of CBD on Sleep Quality Following Late Evening Exercise
The trial is a double-blind, placebo-controlled crossover design. In a randomized order, 20 participants undergo one control and two experimental sessions separated by a 1-week wash out period.
- Trial name
- NCT07570472
- Testing
- late evening exercise
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Carbon Monoxide Poisoning, Delayed Neurocognitive Sequelae
The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning
Background and Aim: Carbon monoxide (CO) poisoning is a significant public health issue that can cause delayed neuropsychological sequelae (DNS). DNS mechanisms involve oxidative stress, inflammation, and immune injury.
- Trial name
- NCT06811675
- Testing
- Dexamethasone and N-acetylcysteine (NAC)
- Where
- Taiwan
- Volunteers
- 128 people
- Sponsor
- China Medical University Hospital
Stroke, Stroke Sequelae
Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors
The proposed study is a two-arm randomized clinical trial designed to assess the effects of the StrokeWear system on clinical outcomes over a period of 6-months in chronic stroke survivors.
- Conditions
- Stroke, Stroke Sequelae, Hemiparesis;Poststroke/CVA
- Trial name
- NCT05626894
- Testing
- StrokeWear Motor and Behavioral Intervention, Usual Care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Spaulding Rehabilitation Hospital
COVID-19, SARS CoV 2 Infection
NIH RECOVER Tissue Pathology: Understanding the Long-Term Impact of COVID-19
The Post-Acute Sequelae of SARS-CoV-2 (PASC) Autopsy Study is a cross-sectional study designed to define and characterize the epidemiology, natural history, clinical spectrum, and underlying mechanisms of post-acute effects of…
- Trial name
- NCT05292274
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- NYU Langone Health
Neoplasms
Health Effects of CArdiac FluoRoscopy and MOderN RadIotherapy in PediatriCs - Radiotherapy
The goal of the HARMONIC-RT study is to evaluate late health and social outcomes of contemporary techniques of external beam radiotherapy in paediatric patients, based on the setting-up of a European, long-term registry…
- Trial name
- HARMONIC-RT (NCT04746729)
- Testing
- No intervention
- Where
- 5 sites in Belgium, Denmark and 2 more
- Volunteers
- 2,670 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Sickle Cell Disease, Pulmonary Disease
Cooperative Assessment of Late Effects for SCD Curative Therapies
Sickle Cell Disease is one of the most common genetic diseases in the United States, occurring in approximately 1 in 400 births. Approximately 100,000 individuals are diagnosed with SCD in the United States.
- Conditions
- Sickle Cell Disease, Pulmonary Disease, Renal Disease, Heart Disease
- Trial name
- COALESCE (NCT05153967)
- Where
- 5 sites in United States
- Volunteers
- 377 people
- Sponsor
- Vanderbilt University Medical Center
Stroke; Sequelae
Postural Decoding for Post-Stroke Shoulder Pain: A RCT.
Brief Summary Purpose of the Study: This clinical trial aims to determine whether Postural Decryption Technique can effectively treat hemiplegic shoulder pain (HSP) in patients recovering from stroke.
- Trial name
- NCT06763796
- Testing
- Postural Decryption Technique, Traditional Chinese Medicine (TCM) Massage Therapy
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shenzhen Baoan District Fuyong People's Hospital
Late-Life Adults, Late-Life Prodromal Depression
Effects of Mindfulness or Brain Stimulation Intervention for Late-life Adults in Taiwan Urban and Rural Areas
This randomized controlled trial will examine the effects of mindfulness-based interventions and brain stimulation interventions on cognitive function and psychological well-being in older adults.
- Conditions
- Late-Life Adults, Late-Life Prodromal Depression, Late-Life Depression, Mindfulness
- Trial name
- PredictNPI (NCT07186023)
- Testing
- MBSR, MBWC, MBCI
- Where
- 2 sites in Taiwan
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Breast Feeding, Exclusive Breast Feeding
Hybrid Breastfeeding Education in Late Pregnancy: Effects on Antenatal Attachment and Breastfeeding
This randomized controlled study aims to examine the effect of individualized hybrid breastfeeding education provided during late pregnancy on antenatal attachment and breastfeeding behaviors among first-time mothers.
- Conditions
- Breast Feeding, Exclusive Breast Feeding, Maternal-Fetal Attachment, Primiparity
- Trial name
- NCT07478341
- Testing
- Individualized Hybrid Breastfeeding Education
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Emel GÜÇLÜ CİHAN
Stroke Patients, Stroke
Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
The Investigators are running a small, early-phase research study across several hospitals in Melbourne, Australia. The study will involve up to 100 young adults between the ages of 18 and 55 who have had a stroke.
- Conditions
- Stroke Patients, Stroke, Stroke; Sequelae, Young Adults
- Trial name
- NCT07019493
- Testing
- Observational Cohort
- Where
- 2 sites in Australia
- Volunteers
- 100 people
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Post-acute Sequelae of COVID-19, Long COVID
SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
The purpose of this research study is to test if the combination of three drugs, valacyclovir, celecoxib, and Paxlovid will decrease the symptoms of Long COVID in adults compared to a placebo (this does not contain the…
- Trial name
- SHIELD (NCT07597902)
- Testing
- Valacyclovir, Celecoxib, Paxlovid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Stroke
Psychometric Study of the Spanish Version of Two Upper Limb Assessment Scales in Chronic Stroke
The purpose of this cross-sectional study is to translate and cross-culturally adapt to Spanish the Motor Evaluation Scale for Upper Extremity in Stroke Patients (MESUPES) and the Stroke Upper Limb Capacity Scale (SULCS) and to…
- Trial name
- NCT05872191
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Valencia
Childhood Cancer, Genetic Predisposition
Genetic Risks for Childhood Cancer Complications in Switzerland
The objectives of the GECCOS project are to identify genetic variants associated with complications of childhood cancer using genotype-phenotype association studies.
- Conditions
- Childhood Cancer, Genetic Predisposition, Late Effect
- Trial name
- GECCOS (NCT04702321)
- Testing
- Procedure: Biospecimen Collection, Procedure: Medical Chart Review
- Where
- Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Geneva
Long COVID, Long Covid19
Understanding the Long-term Impact of COVID-19 in Adults
Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences.
- Trial name
- NCT07498504
- Where
- United States
- Volunteers
- 5,205 people
- Sponsor
- NYU Langone Health
Post-Acute COVID-19 Syndrome
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from an acute COVID-19 infection may continue to have symptoms that persist for months or years.
- Trial name
- NCT07388550
- Testing
- Keytruda
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)