Clinical trials: Late Life Depression
Depression
Cortical/Subcortical Circuits in Late-Life Depression
The purpose of the study is to examine the relationship between brain structure and depression in adults aged 60 or older. This relationship is determined using magnetic resonance imaging technology (MRI), a scanner with a magnet…
- Trial name
- NCT01327417
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Late Life Depression
One-Year Trajectory of Cognitive Changes in Patients With Late-life Depression in the Short Term
The purpose of this study was to investigate the one-year trajectory of cognitive change in elderly patients with depression, to explore the transfer characteristics and transfer rules of various states of cognitive impairment in…
- Trial name
- NCT06447428
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Depression, Dementia
Antidepressant Medication Plus Donepezil for Treating Late-life Depression
This study will determine the effectiveness of combining escitalopram, venlafaxine, or duloxetine with donepezil, a medication used in Alzheimer's disease, in improving memory, concentration, attention, and problem solving…
- Trial name
- NCT00177671
- Testing
- Escitalopram, Donepezil, Venlafaxine
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Late Life Depression, Cognitive Decline
Dopaminergic Dysfunction in Late-Life Depression
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments.
- Conditions
- Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa
- Trial name
- D3 (NCT04469959)
- Testing
- L-Dopa
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Late-Life Depression
Determining Changes in Brain Structure Associated With Symptoms of Late-life Depression
This study will determine the changes in brain structure and function that are responsible for mood and cognition changes that are sometimes associated with late-life depression.
- Trial name
- NCT00178087
- Where
- 2 sites in United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Pathophysiology of Neurodegeneration in Late-life Depression (AV45+THK)
Late-life depression has been frequently associated with cognitive impairment. Several meta-analyses consistently suggested that a history of depression approximately doubles an individual's risk for developing dementia later in…
- Trial name
- NCT03430869
- Testing
- F-18 AV-45, F-18-THK-5351
- Where
- Taiwan
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Unipolar Depression
The Effects of Sleep Deprivation on Antidepressant Response
This study will use positron emission tomography (PET) to examine the effect of sleep deprivation on brain function.
- Trial name
- NCT00178074
- Testing
- total sleep deprivation, PET imaging
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Major Depression
Duke Conte Center for the Neuroscience of Depression in Late Life
The proposed Silvio O. Conte Center for Neuroscience of Depression will focus on understanding the neurobiological mechanism of depression. A total of 5 projects are proposed. The center is focused on a single hypothesis.
- Trial name
- NCT00576875
- Where
- United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression
Apathy in Late Life Depression: New Biomarkers Using Actimetry and Magnetic Resonance Imaging
Old age (> 60 years) is at high risk to develop major depression disorders (MDD). MDD doubles the risk for subsequent cognitive disorders and dementia. Apathy (i.e.
- Trial name
- ACTIDEP (NCT03807167)
- Testing
- Mattis Dementia Rating Scale, Unified Parkinson 's Disease Rating Scale-III, Mini Neuropsychiatric Investigation
- Where
- 6 sites in France
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital