Clinical trials: Late-life Depression
Unipolar Depression
Paroxetine and Interpersonal Psychotherapy for Maintaining Health and Well-being in Elderly Individuals With Depression
This study will evaluate the effectiveness of paroxetine versus interpersonal psychotherapy and a combination of the two in helping elderly patients with depression remain well and improve quality of their lives.
- Trial name
- NCT00178100
- Testing
- Interpersonal Psychotherapy, paroxetine
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder, Depression
Buprenorphine Used With Treatment Resistant Depression in Older Adults
The investigators are conducting a research study to learn about the safety and benefit of using a medication called buprenorphine for patients with difficult to treat depression.
- Trial name
- IRLGreyB (NCT02181231)
- Testing
- venlafaxine XR, buprenorphine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Depression
Vascular Augmentation of Late-life Unremitted Depression (VALUeD)
Depression has a high occurrence and causes other problems in older people, two thirds of these patients will not have a lessening in their condition from routine treatment medication.
- Trial name
- VALUeD (NCT01557153)
- Testing
- Amlodipine
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Gateshead Health NHS Foundation Trust
Late-Life Depression, Anhedonia
Investigating the Efficacy and Mechanisms of Individualized tACS Targeting Anhedonia in Late-Life Depression
This project focuses on clinical translational research into personalized transcranial alternating current stimulation (tACS) for treating anhedonia in late-life depression (LLD).
- Trial name
- NCT07637773
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jie Li
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Depression
Late-life Depression and Cerebral Perfusion
The long-term goal is to determine if decreased blood flow to the brain (cerebral hypoperfusion) is predictive of antidepressant outcomes in late-life depression (LLD).
- Trial name
- NCT01751828
- Testing
- Sertraline
- Where
- United States
- Sponsor
- Vanderbilt University
Late-life Depression, Treatment-resistant Depression
SSM vs HEP in Late-Life Depression
The investigators will conduct a randomized controlled trial (RCT), comparing SSM (n=96) versus HEP (n=96) in 192 LLD participants stratified by site and presence of treatment resistant late life depression (TR-LLD).
- Trial name
- NCT03564041
- Testing
- Sahaj Samadhi Meditation (SSM), Health Enhancement Program (HEP)
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression in Old Age
High-definition Transcranial Direct Current Stimulation (HD-tDCS) in Late-life Depression (LLD)
To determine the efficacy of a 2-week daily programme (10 sessions) of HD-tDCS to augment antidepressant therapy in subjects with late-life depression who had residual depressive symptoms despite adequate dosage and duration of…
- Trial name
- NCT05322863
- Testing
- High-definition Transcranial Direct Current Stimulation
- Where
- Hong Kong
- Volunteers
- 58 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment, Major Depressive Disorder
Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression
The overall goals of this project are to assess the feasibility and impact of designing and implementing an at-home intervention aimed at preventing long-term cognitive decline and improving cognition in individuals currently…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Alzheimer's Dementia, Transcranial Direct Current Stimulation
- Trial name
- NCT02959502
- Testing
- Receive tDCS+CR, Facilitate tDCS + CR
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Depression
Psychotherapy for Late Life Depression
This randomized pilot study will test the feasibility of a behavioral intervention for late life depression. Enrolled participants will receive 9 weeks of a specialized form of psychotherapy we call "ENGAGE" or standard of care…
- Trial name
- ENGAGE-II (NCT01698255)
- Testing
- ENGAGE, Standard of Care Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Weill Medical College of Cornell University
Alcoholism, Depression
Treating Alcohol Use In Older Adults With Depression
The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.
- Trial name
- NCT00018824
- Testing
- NALTREXONE
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- US Department of Veterans Affairs
Hearing Loss, Depression
Treating Hearing Loss to Improve Mood and Cognition in Older Adults
Age-related hearing loss (ARHL) is the third most common health condition affecting older adults after heart disease and arthritis and is the fifth leading cause of years lived with disability worldwide.
- Trial name
- NCT03321006
- Testing
- Phonak Audeo B-R 90 hearing aid device (Active), Duloxetine or escitalopram
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Depression
A Randomized Sham-Controlled Study of H-Coil Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Late-Life Depression
The purpose of the study is to explore the efficacy and safety of H-Coil rTMS in comparison to a sham H-Coil rTMS in older patients with treatment-resistant major depressive disorder.Subjects will be randomized to receive H1-Coil…
- Trial name
- NCT01760681
- Testing
- H- Coil DTMS
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Shalvata Mental Health Center
Late Life Depression
One-Year Trajectory of Cognitive Changes in Patients With Late-life Depression in the Short Term
The purpose of this study was to investigate the one-year trajectory of cognitive change in elderly patients with depression, to explore the transfer characteristics and transfer rules of various states of cognitive impairment in…
- Trial name
- NCT06447428
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Major Depressive Disorder
Biomarkers for Outcomes In Late-life Depression (BOLD)
Major depressive disorder (MDD) is a common psychiatric illness with high cost to society and individual patients. One reason for the high cost is that most patients endure lengthy and ultimately unsuccessful empiric…
- Trial name
- BOLD (NCT01082237)
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Melancholia
Serotonin Transporter Density in Late-life Depression With and Without Dementia
This study will recruit a total of 40 evaluable subjects (20 cognitively depressive, and 20 AD depressive); each evaluable subject involved in this study must fulfill all the inclusion and exclusion criteria according the subject…
- Trial name
- NCT01548937
- Testing
- I-123 ADAM
- Volunteers
- 39 people
- Sponsor
- Chang Gung Memorial Hospital
Major Depression, Dysthymic Disorder
Improving Depression Care for Elders: Coordinating Center
Purpose: To determine the effectiveness of the Improving Mood-Promoting Access to Collaborative Treatment(IMPACT) collaborative care management program for late-life depression.
- Conditions
- Major Depression, Dysthymic Disorder, Both Major Depression and Dysthymic Disorder
- Trial name
- IMPACT (NCT01561105)
- Testing
- IMPACT
- Volunteers
- 1,801 people
- Sponsor
- University of California, Los Angeles
Depression
Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals
This study will determine the effectiveness of total sleep deprivation (TSD) for one night plus paroxetine versus either TSD plus placebo or paroxetine alone in inducing rapid symptom resolution of major depression in the elderly.
- Trial name
- NCT00178035
- Testing
- paroxetine, One night of Total Sleep Deprivation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Pittsburgh
Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder
The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
The goal of this clinical trial is to test whether a personalized approach to treatment selection improves symptoms in older adults with treatment-resistant depression.
- Conditions
- Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- BAARD (NCT07810738)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation
- Where
- 3 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Depression
Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression
The goal of this study is to find out if the antihistamine, clemastine, can make the white matter in the brain better in older adults with depression.
- Trial name
- CLIMB (NCT06591091)
- Testing
- Clemastine Fumarate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Illinois Chicago