Clinical trials: Late-life Depression
Late Life Depression
CM Delivered PST in LLD Pilot
This study seeks to determine the feasibility and efficacy of a Problem Solving Therapy intervention for the treatment of late life depression (LLD).
- Trial name
- NCT03408821
- Testing
- Problem Solving Therapy (PST)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Late Life Depression
Explore the Neural Mechanism of Mindfulness Training to Reduce Loneliness in Depressed Older Adults
Perceived loneliness causes a global health burden on older adults. Mindfulness training may be a feasible solution. Through our study, we expect that comprehensive and convincing neuroscientific evidence may support the efficacy…
- Trial name
- NCT05620511
- Testing
- Mindfulness based stress reduction
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Cognition, Depression
To Enhance Cognition in Late Life Depression Using Transcranial Direct Current Stimulation
Late Life Depression (LLD) is a serious health problem which not only causes depressed mood but also results in impairments in memory and attention.
- Trial name
- NCT02212366
- Testing
- Active TDCS
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre for Addiction and Mental Health
Depression
Village-based Intervention for Late-life Depression
Investigators aimed to examine the feasibility and effectiveness of a village-based multilevel intervention for late-life depression.
- Trial name
- NCT04013165
- Testing
- Active control, Village-based intervention
- Where
- South Korea
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Depressive Disorder, Major
NMDA Modulation in Major Depressive Disorder in Late- Life
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Most of the current antidepressants are based upon the monoamine hypothesis which cannot fully explain the etiology of depression.
- Trial name
- NCT03414931
- Testing
- NMDA, Sertraline
- Where
- 2 sites in Taiwan
- Volunteers
- 136 people
- Sponsor
- Chang Gung Memorial Hospital
Late Life Depression
Automatic Self Transcending Meditation (ASTM) Versus Heart Rate Variability (HRV) Biofeedback in Patients With Late Life Depression (LLD): a Longitudinal Pilot Feasibility Study
Background: Depression in the elderly, also known as late life depression (LLD) is common and its prevalence ranges from 2 to 6% in the community.
- Trial name
- NCT01908673
- Testing
- HRV biofeedback, ASTM
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression, Late Life Mood Disorder
A Study on Better Cognitive Functioning Through Braintraining on the Internet
This study evaluates the efficacy of an eight-week online cognitive training program on feasability and on objective and subjective cognitive functions in patients with late life mood disorders (LLMD).
- Conditions
- Depression, Late Life Mood Disorder, Impaired Cognition, Alteration in Mood
- Trial name
- BrainFit (NCT04006756)
- Testing
- Online cognitive training 1, Online cognitive training 2
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Amsterdam UMC, location VUmc
Depression
Evaluation of Metacognitive Training for Depression in Later Life (MCT-Silver)
The study will evaluate the efficacy of metacognitive training for depression in later life (MCT-Silver) vs. cognitive remediation (mybraintraining©) in reducing depressive symptoms among older adults.
- Trial name
- NCT03691402
- Testing
- MCT-Silver, Cognitive Remediation
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Major Depressive Disorder, Neuroticism
Predictors of Cognitive Outcomes in Geriatric Depression
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging.
- Conditions
- Major Depressive Disorder, Neuroticism, Cognitive Change, Stress
- Trial name
- NBOLD (NCT05273996)
- Testing
- Sertraline, bupropion, desvenlafaxine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- David Steffens
Major Depressive Disorder
Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial
Background Adults over the age of 60 with symptoms of major depressive disorder are said to have late-life depression (LLD), a condition that usually decreases a person's quality of life and is associated with other risks like…
- Trial name
- LLDOPA (NCT06626152)
- Testing
- Apo-levocarb
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Depression, Major Depressive Disorder
Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine
The purposes of this project are to examine the feasibility, safety, tolerability and clinical effect of low-dose buprenorphine as a novel treatment for late-life treatment-resistant depression and to develop preliminary data…
- Trial name
- IRLGREY-B (NCT02176291)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Jordan F. Karp
Late Life Depression
TBS,TMS, Suicidal Ideation, Magnetic Resonance Imaging, Dorsolateral Prefrontal Cortex, Ventrolateral Prefrontal Cortex
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique, its approved therapeutic indication is high-frequency stimulation to the left dorsolateral prefrontal cortex (DLPFC) for treatment resistant.
- Trial name
- NCT05010915
- Testing
- Transcranial magnetic stimulation
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Loneliness, Well-Being, Psychological
A Randomized Controlled Trial of Robotic Support for Enhanced Later Life (RoSELL)
The purpose of this study is to compare the efficacy of a personalized, co-designed robot interaction against a standardized, fixed robot interaction for reducing loneliness, depression, as well as improving self-agency and…
- Conditions
- Loneliness, Well-Being, Psychological, Depression - Major Depressive Disorder
- Trial name
- RoSELL (NCT07102017)
- Testing
- Co-Design LOVOT Intervention, Standard LOVOT Intervention
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Melanoma, Quality of Life
Quality of Life and Surgical Late Effects of Melanoma Treatment
Health-related Quality of life in Danish stage IB-III cutaneous melanoma patients.
- Conditions
- Melanoma, Quality of Life, Lymphedema, Depression
- Trial name
- NCT02352623
- Testing
- DXA scan, Clinical examination
- Where
- Denmark
- Volunteers
- 435 people
- Sponsor
- Herlev Hospital
Major Depressive Disorder
LEPR Polymorphism Weight Gain by Mirtazapine in Late Life Depression
Patients with an episode of depression in late life prescribed mirtazapine recruited from a clinical sample will be monitored for weight and receive a blood test during their usual course of treatment to determine polymorphisms…
- Trial name
- NCT01601002
- Testing
- Mirtazapine
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression
Augmenting Antidepressant Treatment With Interpersonal Psychotherapy for Treating Late-life Depression
This study will determine whether adding interpersonal psychotherapy to treatment with the antidepressant escitalopram will be more effective in reducing symptoms of depression than antidepressant medication alone.
- Trial name
- NCT00177294
- Testing
- Escitalopram, Interpersonal Psychotherapy, Clinical Monitoring
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- University of Pittsburgh
Depression
Effect of Brain Lesion Severity on Treatment Response in Late-Life Depression
This study will determine the relationship between brain lesion severity, treatment response, and frontal lobe brain function in people with late-life depression (LLD).
- Trial name
- NCT00339066
- Testing
- Sertraline
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Duke University
Depression
Primary Prevention of Major Depression in Later Life
The Institute of Medicine has called for studies of "indicated" preventive interventions to reduce the incidence of mental illness in persons already symptomatic but not yet presenting with fully developed clinical syndromes.
- Trial name
- NCT00326677
- Testing
- Problem Solving Therapy, Dietary Education
- Where
- 2 sites in United States
- Volunteers
- 306 people
- Sponsor
- University of Maryland, College Park
Depression, Cognitive Impairment
1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study)
Growing evidence suggests that dopamine contributes to key cognitive, emotional, and motor functions across the lifespan. In Late-Life Depression (LLD), dysfunction in these areas is common, predicts poor outcomes, and manifests…
- Conditions
- Depression, Cognitive Impairment, Gait Impairment
- Trial name
- NCT04493320
- Testing
- Carbidopa/levodopa
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Fatigue, Depression, Anxiety
Fatigue As a Late Effect in Breast Cancer Survivors - is Acupuncture a Treatment Option?
The success of treatment of breast cancer has improved, hence the prevalence of survivors have increased. However, experienced late effects from the cancer itself or from cancer treatment is substantial.
- Conditions
- Fatigue, Depression, Anxiety, Insomnia, Hot Flashes
- Trial name
- NCT04418115
- Testing
- Acupuncture; based on Tradidtional Chinese Medicine
- Where
- Norway
- Volunteers
- 223 people
- Sponsor
- Kristiania University College