Clinical trials: Late-life Depression
Late Life Depression
Exploration of the Potential Mechanisms of n-3 Fatty Acids Supplementation in Depression and Cognitive Function in Patients With Late-life Depression
Depression in the elderly causes considerable distress, disability, and loss of life. The accelerating aging boom is accentuating the importance of addressing late life depression (LLD).
- Trial name
- NCT05972798
- Testing
- Omega-3 fatty acids, Soybean oil
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Depressive Symptoms, Depression
Virtual Therapy as a Method Supporting Treatment of Late-Life Depression
This study evaluates the addition of virtual therapy intervention in the treatment of depression in the elderly. Half of the participants will receive virtual reality treatment as an addition to physical exercises and…
- Conditions
- Depressive Symptoms, Depression, Anxiety
- Trial name
- NCT04047511
- Testing
- VRTierOne, Group general fitness training, Group Psychoeducation
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Depressive Symptoms, Depression
Virtual Therapeutic Garden for Depressive Symptoms
This study evaluates the addition of virtual therapy intervention in the treatment of depression in the elderly. Half of the participants will receive virtual reality treatment as an addition to physical exercises and…
- Conditions
- Depressive Symptoms, Depression, Anxiety
- Trial name
- NCT05285501
- Testing
- Group general fitness training, Group relaxation and psychoeduaction, VRTierOne
- Where
- 2 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Depression Mild, Depressive Disorder, Major
Cognitive Fitness for Depression in Older Adults
This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants.
- Conditions
- Depression Mild, Depressive Disorder, Major, Mild Cognitive Impairment
- Trial name
- NCT04790630
- Testing
- Computerized Cognitive Remediation of Executive Functioning (CCR-EF), Active Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- UConn Health
Major Depressive Disorder
Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression
The specific focus of this study is to gather data regarding the effects of a psychological therapy known as Problem Solving Therapy (PST) on cerebral blood flow (CBF), cortical gray matter (GM) atrophy, subcortical white matter…
- Trial name
- PRS (NCT02440815)
- Testing
- Problem Solving Therapy
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression in Old Age
Fitness for Brain Optimization for Late-Life Depression
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD).
- Trial name
- FIT BOLD (NCT04670510)
- Testing
- On-site AE, At-home AE, Social Engagement (SE)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Mechanisms of Antidepressant Non-Response in Late-Life Depression
This project seeks to elucidate the mechanisms by which antidepressant medications have limited efficacy in Late Life Depression (LLD) in order to develop new treatment interventions for this prevalent and disabling illness.
- Trial name
- NCT01931202
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- New York State Psychiatric Institute
Late-Life Depression, Resistant Depression, Treatment
Nitrous Oxide for Late-Life Depression - PROTO-BRAIN
Resistant Depression is a common condition in older adults and there is an urgent need for novel antidepressant in this population.
- Trial name
- PROTO-BRAIN (NCT05007028)
- Testing
- EMONO, Medical Air
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Tours
Treatment Resistant Depression (TRD), Late Life Depression (LLD)
Lumateperone for Late-Life Depression
The purpose of this research study is to examine how well a medication called lumateperone (Caplyta) works to relieve depression in older adults with treatment-resistant depression. Lumateperone (Caplyta) is approved by the U.S.
- Conditions
- Treatment Resistant Depression (TRD), Late Life Depression (LLD), Depression / Major Depressive Disorder
- Trial name
- IRL Grey-C (NCT07623135)
- Testing
- Lumateperone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Eric Lenze
Memory Impairment, Executive Dysfunction
The Effects of Playing High School Football on Later Life Cognitive Functioning and Mental Health
The purpose of this study is to assess the effect of playing high school football on later in life cognitive functioning and mental health.
- Conditions
- Memory Impairment, Executive Dysfunction, Depression
- Trial name
- NCT02833129
- Volunteers
- 3,904 people
- Sponsor
- University of Pennsylvania
Depression, Anxiety
Study of Dronabinol Treatment for Depression and/or Anxiety in Older Patients
This is an observational study evaluating the safety and efficacy of dronabinol for the treatment of anxiety and/or depression in older adults.
- Trial name
- NCT03369639
- Where
- United States
- Sponsor
- Mclean Hospital
Bipolar Disorder
Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study
The purpose of this study is to collect pilot data on the feasibility of recruiting, eliciting informed consent, assessing, treating, and following patients aged 60 and older with bipolar mood disorders.
- Trial name
- NCT00177567
- Testing
- lithium carbonate, Depakote-ER, risperidone
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Late-Life Depression
Fish Oil Supplementation in Late-life Depression
To investigate whether fish oil supplementation, compared to placebo (olive oil), could have better effects on depression course and cognitive function in older people with major depression.
- Trial name
- NCT01235533
- Testing
- N-3 polyunsaturated fatty acids
- Where
- 2 sites in Taiwan
- Volunteers
- 89 people
- Sponsor
- Taipei City Psychiatric Center, Taiwan
Depression
Examining the Feasibility and Effectiveness of Case Manager Delivered Problem Solving Therapy on Late Life Depression
This study seeks to determine the feasibility and efficacy of a Problem Solving Therapy intervention for the treatment of late life depression (LLD).
- Trial name
- NCT02505178
- Testing
- Problem Solving Therapy
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Late-Life Depression
Effects of Specific Amino Acid Supplementation and Lifestyle Factors on Brain Ageing
The aim of this clinical trial is to investigate the effects of L-serine supplementation on cognitive decline and psychosocial functioning in older adults with late-life depression (LLD).
- Trial name
- AAAgeing (NCT07497347)
- Testing
- L-serine supplementation
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Primary Insomnia, Depression
Paroxetine in the Treatment of Chronic Primary Insomnia
The goal of the study is to examine the role of paroxetine, an antidepressant medication, in the acute and continuation treatment of insomnia.
- Trial name
- NCT00178048
- Testing
- paroxetine
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Pittsburgh
Depression in Old Age, Psychotherapy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations.
- Conditions
- Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
- Trial name
- NCT05356611
- Testing
- Engage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nevada, Las Vegas
Depressive Disorder
Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing
In this new research study, 80 adults aged > 60 years with a significant depressive disorder and slowed processing and/or gait speed will be randomized to receive levodopa (L-DOPA; which the Candidate has previously shown to…
- Trial name
- NCT04650217
- Testing
- Carbidopa/levodopa, Exercise training, Control
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- New York State Psychiatric Institute
Depressive Symptoms, Caregiver Burden
Caregiver Stress and Sleep Study
The purpose of this research study is to better understand how stress, sleep and activity might impact caregivers' mood and brain health.
- Trial name
- CARES (NCT05219955)
- Testing
- Morning Action Plan Execution, Activity Strategy-based Session with Therapist, Attention-based Session with Therapist
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Late Radiation Injury, Chronic Pain
HBOT Late Radiation Tissue Injury
Background: Radiotherapy is a common treatment for many malignancies. Radiation-related complications developing months or years after radiation treatment are known as late radiation tissue injury (LRTI) and are estimated to…
- Trial name
- NCT02425215
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto