Clinical trials: Late-life Depression
Late Life Depression (LLD), Depression - Major Depressive Disorder
Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS protocol (where participants receive multiple TBS treatments daily) to conventional TBS protocol (where…
- Conditions
- Late Life Depression (LLD), Depression - Major Depressive Disorder, Depressive Disorder, Treatment-Resistant, Mood Disorders
- Trial name
- ACT-LLD (NCT06854367)
- Testing
- TBS
- Where
- 2 sites in Canada
- Volunteers
- 280 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Reward Function and Therapy for Late-Life Depression
The goal of this study is to learn about changes in the brain that occur during Engage, a psychotherapy for depression in older adults, and how they may differ from changes that occur during supportive therapy.
- Trial name
- NCT03688139
- Testing
- Engage Therapy, Supportive Therapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
Gait, Depression, and Mind-body Therapy in Seniors
Falls are the leading cause of injury---related hospitalization and death in the elderly. As such, fear of falling (FOF) is common among senior populations and often leads to activity avoidance, social isolation, and reduced…
- Trial name
- NCT02283541
- Testing
- Automatic self-transcending meditation
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression, Inflammation
Stress and Inflammation in Late-Life Depression
Over 18% of Americans aged 65 years and older have depression. Recent evidence suggests that there is a link between depression and inflammatory disease.
- Trial name
- S&I (NCT02389465)
- Testing
- Escitalopram + Celecoxib
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Suicide, Bereavement
Risk and Resilience to Suicide Following Late-Life Spousal Bereavement
The purpose of the RISE study is to examine how the 24-hour rhythm of sleep and social activity relate to mood and suicidal ideation among older adults that recently lost a spouse or life partner.
- Trial name
- RISE (NCT06191484)
- Testing
- WELL Behavioral Probe
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Electroconvulsive Therapy Amplitude Titration
This study is focused on advancing ECT treatment for older adults with depressive disorders by refining neuromodulation stimulus parameters to improve efficacy and cognitive safety.
- Trial name
- NCT04621786
- Testing
- Mecta Spectrum 5000Q paired with Soterix Medical 4X1 HD - ECT Multi-Channel Stimulation Interface
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of New Mexico
Depression, Suicide
Intranasal Ketamine for Late-Life Depression and Suicidal Ideation
The investigators of this study plan to investigate the feasibility and efficacy of repeated doses of intranasal ketamine in severely depressed patients who are at least 65 years of age and experiencing suicidal ideation.
- Conditions
- Depression, Suicide, Suicidal Ideation
- Trial name
- NCT02295787
- Testing
- Ketamine
- Sponsor
- Massachusetts General Hospital
Breast Neoplasms, Quality of Life
Breast Cancer and Resilience in Couple
This is a prospective pilot study examining the couple's dyadic attitudes from diagnosis to 24 months later when one member is affected by illness and the adaptive strategies the couple employs when stressful events occur.
- Trial name
- resilience (NCT06875414)
- Testing
- Nursing care model
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Anxiety Disorders, Anxiety Depression
Exposure Therapy for Late-life Anxiety
The primary objective is to evaluate the (cost-)effectiveness of exposure therapy (ET) delivered by trained mental health nurses (MHNs) in terms of anxiety symptoms and quality of life for late life anxiety disorders in primary…
- Trial name
- DeFEAD65+ (NCT06770517)
- Testing
- Exposure therapy, Usual Care
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- ProPersona
Depression in Old Age, Recurrence
Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-Life Depression
Late-life depression (LLD) is associated with disability, increased risk for cognitive decline and dementia, elevated suicide risk, and greater all-cause mortality.
- Conditions
- Depression in Old Age, Recurrence, Cognitive Dysfunction
- Trial name
- REMBRANDT (NCT05331599)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Depression, Major Depressive Disorder
Flavanol Augmentation for Antidepressant Non-Responsive Late Life Depression
The goal of this proposal is to conduct the first pilot study of whether consuming flavanol supplements will augment the cognitive and mood benefits of antidepressant medication in older adults with Late LifeDepression (LLD).
- Trial name
- Flavanol (NCT02943096)
- Testing
- CocoaVia
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- New York State Psychiatric Institute
Pulmonary Hypertension
Pulmonary Hypertension, Quality of Life and Psychosocial Factors
The investigators aim to : describe and analyse psychological characteristics, cognitive factors and representations in patients with Pulmonary Hypertension, a rare disease.
- Trial name
- HyPsy (NCT01380054)
- Testing
- Evaluation of quality of life
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder
Games to Overcome Late Life Depression
This is a pilot study divided into two phases. IN phase 1 (completed) participants will be randomized to receive 8 weeks of Problem Solving Therapy (PST) alone or 8 weeks of a cognitive training game called, Evolution (Evo) plus…
- Trial name
- GOLD (NCT02229188)
- Testing
- Problem Solving Therapy, Evolution, Words
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Washington