Clinical trials: Later Life
Fatigue, Depression, Anxiety
Fatigue As a Late Effect in Breast Cancer Survivors - is Acupuncture a Treatment Option?
The success of treatment of breast cancer has improved, hence the prevalence of survivors have increased. However, experienced late effects from the cancer itself or from cancer treatment is substantial.
- Conditions
- Fatigue, Depression, Anxiety, Insomnia, Hot Flashes
- Trial name
- NCT04418115
- Testing
- Acupuncture; based on Tradidtional Chinese Medicine
- Where
- Norway
- Volunteers
- 223 people
- Sponsor
- Kristiania University College
Major Depression
Predictors of the Outcome of Late Life Depression
Predictors of response to pharmacological treatment of major depressive disorder will be investigated. One hundred and twenty patients will be included in a naturalistic clinical trial.
- Trial name
- NCT02441387
- Testing
- Antidepressant, Psychoeducation, Treatment as usual (only pharmacological treatment).
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Major Depression
Duke Conte Center for the Neuroscience of Depression in Late Life
The proposed Silvio O. Conte Center for Neuroscience of Depression will focus on understanding the neurobiological mechanism of depression. A total of 5 projects are proposed. The center is focused on a single hypothesis.
- Trial name
- NCT00576875
- Where
- United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Duke University
Major Depressive Disorder
Electroconvulsive Therapy Amplitude Titration
This study is focused on advancing ECT treatment for older adults with depressive disorders by refining neuromodulation stimulus parameters to improve efficacy and cognitive safety.
- Trial name
- NCT04621786
- Testing
- Mecta Spectrum 5000Q paired with Soterix Medical 4X1 HD - ECT Multi-Channel Stimulation Interface
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of New Mexico
Social Connection, Loneliness
Engage Coaching (R33 Phase)
The purpose of this study is to test whether an individual coaching program helps adults age 60 and older feel more connected to other people in ways that matter to them.
- Conditions
- Social Connection, Loneliness, Suicide Ideation, Social-emotional Quality of Life
- Trial name
- NCT07488559
- Testing
- Social Engage Coaching (S-ENG)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester
Schizophrenia
Cognitive Behavioral Social Skills Training for Patients With Late-Life Schizophrenia: a Pilot Study
Schizophrenia is associated with significant cognitive and functional deficits. As patients with schizophrenia grow older, the impact of these deficits at a personal and public health level is likely to increase.
- Trial name
- CBSST (NCT00832845)
- Testing
- CBSST plus treatment as usual, Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre for Addiction and Mental Health
Late Life Depression (LLD), Depression - Major Depressive Disorder
Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS protocol (where participants receive multiple TBS treatments daily) to conventional TBS protocol (where…
- Conditions
- Late Life Depression (LLD), Depression - Major Depressive Disorder, Depressive Disorder, Treatment-Resistant, Mood Disorders
- Trial name
- ACT-LLD (NCT06854367)
- Testing
- TBS
- Where
- 2 sites in Canada
- Volunteers
- 280 people
- Sponsor
- Centre for Addiction and Mental Health
Hypogonadism
NEBIDO in Symptomatic Late Onset Hypogonadism (SLOH)
The design of the study is a standard double-blind design, which is needed in this study to allow for unbiased evaluation of efficacy and safety.
- Trial name
- NCT01092858
- Testing
- Testosterone Undeconate (Nebido, BAY86-5037)
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Bayer
Accidental Falls, Exercise
Exercising With Computers in Later Life
This is a pilot study to assess whether balance training with the Nintendo® Wii is comparable to a physiotherapist-led falls group in terms of improvement in balance. The acceptability of the Nintendo® Wii will also be assessed.
- Trial name
- EXCELL (NCT01082042)
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- NHS Grampian
Multiple Sclerosis
Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life
Multiple sclerosis patients commonly develop generalized ventricular dilation with or without cerebral atrophy over time. Case studies in the literature have noted some multiple sclerosis patients develop the typical "normal…
- Trial name
- NCT01377805
- Where
- United States
- Sponsor
- Genetic Disease Investigators
Aging
Resveratrol and Exercise to Treat Functional Limitations in Late Life
The purpose of this research study is to evaluate the effects of combining physical exercise with a resveratrol supplementation on the physical function of older adults.
- Trial name
- NCT02523274
- Testing
- Resveratrol, Exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Depressive Symptoms, Metabolic Syndrome X
Reducing Disparities in Late Life Depression and Metabolic Syndrome
Linkages between depression and cardiovascular disease have been well documented. These appear to be more than associations, and may reflect causal relationships through a number of proposed pathways, including decreased physical…
- Conditions
- Depressive Symptoms, Metabolic Syndrome X, Overweight, Obesity
- Trial name
- BRIGHTEN-Heart (NCT01428791)
- Testing
- Generations older adult membership program, BRIGHTEN Heart Virtual Team intervention
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Unipolar Depression
The Effects of Sleep Deprivation on Antidepressant Response
This study will use positron emission tomography (PET) to examine the effect of sleep deprivation on brain function.
- Trial name
- NCT00178074
- Testing
- total sleep deprivation, PET imaging
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Frailty, Sarcopenia
Effect of Exercise-education Program PERMANENTO in Late Life
The general aim of the present study is to create and empirically evaluate (RCT trial) an online education and exercise program (called PERMANENTO) to help older adults to understand the wider consequences of being active and…
- Trial name
- PERMANENTO (NCT06133894)
- Testing
- Exercise program PERMANENTO inspired by developmental kinesiology
- Where
- Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Depression
Preventing the Return of Depression in Elderly Patients
The purpose of this study is to compare the effectiveness of two doses of nortriptyline in elderly patients whose depression returned after stopping treatment. Nortriptyline is an antidepressant.
- Trial name
- NCT00000377
- Testing
- Nortriptyline
- Sponsor
- University of Pittsburgh
Osteoarthritis (OA)
Does Surgical Treatment of Cartilage Defects Prevent Osteoarthritis in Later Life?
Observational study to assess the effectiveness of cell therapy for the treatment of osteoarthritis
- Trial name
- REACT (NCT07320118)
- Where
- 2 sites in United Kingdom
- Volunteers
- 650 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Depression, Anxiety Disorder
Preventing Depression in Late Life: A Model for Low and Middle Income Countries
This study is being conducted in GOA India. The study addresses specific issues of depression prevention in older adults living in low- and middle income countries (LMICs), by developing risk-reduction strategies through the use…
- Trial name
- NCT02145429
- Testing
- Problem Solving therapy and Brief Behavioral Treatment of Insomnia
- Where
- India
- Volunteers
- 181 people
- Sponsor
- University of Pittsburgh
Anxiety Disorders Generalized
A Pilot fMRI Study of TMS in Late-Life Severe Worry
Investigators will test a novel intervention through experimental therapeutic approach using fMRI-directed Intermittent Theta Burst Stimulation (iTBS), a high frequency TMS paradigm, for the treatment of severe, uncontrollable…
- Trial name
- TINA (NCT03577106)
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Carmen Andreescu
Anxiety Disorders, Generalized Anxiety Disorder
Drug Therapy for Generalized Anxiety Disorder Among the Elderly
This study will determine the efficacy of escitalopram (Lexapro®), an anti-anxiety drug, for generalized anxiety disorder (GAD) and the ways genetics affect response to treatment for GAD in elderly individuals.
- Trial name
- NCT00105586
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Pittsburgh