Clinical trials: Later Life
Depression Mild, Depressive Disorder, Major
Cognitive Fitness for Depression in Older Adults
This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants.
- Conditions
- Depression Mild, Depressive Disorder, Major, Mild Cognitive Impairment
- Trial name
- NCT04790630
- Testing
- Computerized Cognitive Remediation of Executive Functioning (CCR-EF), Active Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- UConn Health
Depression in Old Age, Quality of Life
RCT of MBCT vs HEP for Late-Life Depression
Study Design \& Recruitment: Phase III randomized controlled trial (RCT) with 100-110 patients. Participants >60 years old, with symptoms of late-life depression (LLD; MADRS score>=10), excluding dementia and other psychiatric…
- Trial name
- NCT05366088
- Testing
- Mindfulness-Based Cognitive Therapy, Health Enhancement Program
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Lady Davis Institute
Neoplasms
Health Effects of CArdiac FluoRoscopy and MOderN RadIotherapy in PediatriCs - Radiotherapy
The goal of the HARMONIC-RT study is to evaluate late health and social outcomes of contemporary techniques of external beam radiotherapy in paediatric patients, based on the setting-up of a European, long-term registry…
- Trial name
- HARMONIC-RT (NCT04746729)
- Testing
- No intervention
- Where
- 5 sites in Belgium, Denmark and 2 more
- Volunteers
- 2,670 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cancer
Rapid Easy Strength Training (REST) to Improve Function in Late Stage Cancer
The purpose of this study is to determine whether a gentle physical conditioning program comprised of isotonic resistive strengthening and pedometer-directed walking can improve the physical functioning and fatigue of patients…
- Trial name
- REST (NCT01334983)
- Testing
- REST
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mayo Clinic
Adverse Effect of Radiation Therapy
IORT-Boost-Study, Prospective Observational Study for Intraoperative Radiotherapy of the Breast as a Boost
In this study the investigators observe the investigation, whether the new method for Boost-Irradiation with the Intrabeam Device of Zeiss Germany influences local recurrence, acute and late effects of Radiotherapy, overall…
- Trial name
- NCT02114086
- Where
- Switzerland
- Volunteers
- 163 people
- Sponsor
- Kantonsspital Münsterlingen
Respiratory Syncytial Virus Infections
A Study to Evaluate the Safety and Efficacy of MEDI8897 for the Prevention of Medically Attended Lower Respiratory Tract Infection Due to Respiratory Syncytial Virus in Healthy Late Preterm and Term Infants (MELODY)
The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics (PK), and antidrug antibody (ADA) response for MEDI8897 in healthy late preterm and term infants who are 35 weeks or greater gestational age and…
- Trial name
- MELODY (NCT03979313)
- Testing
- MEDI8897
- Where
- 198 sites in United States, Argentina and 29 more
- Volunteers
- 3,012 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pelvic Floor Disorder, Female Pelvic Floor Dysfunction
Late Side-effects After Cervical Cancer Treatment - Prevention and Treatment
Late side-effects following gynecological cancer are predominantly symptoms from the pelvic region originating from the bowels, urinary tract, lymphatic system, genitals and musculoskeletal system.
- Conditions
- Pelvic Floor Disorder, Female Pelvic Floor Dysfunction, Female Sexual Dysfunction, Female Urinary Incontinence
- Trial name
- NCT06786091
- Testing
- Pelvic floor muscle training rehabilitation
- Where
- 2 sites in Norway
- Volunteers
- 25 people
- Sponsor
- St. Olavs Hospital
Ehlers Danlos Syndrome, External Hydrocephalus
Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life
It is known that 33-50% of Classic and Hypermobile Ehlers-Danlos Syndrome patients eventually develop dysautonomia, otherwise known as "POTS" (Postural Orthostatic Tachycardia Syndrome).
- Conditions
- Ehlers Danlos Syndrome, External Hydrocephalus, Dysautonomia, Postural Orthostatic Tachycardia Syndrome
- Trial name
- NCT01367977
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Genetic Disease Investigators
HIV Infections, Elderly Infection
HIV Resilience Qualitative Study Hong Kong
This qualitative study aims to explore lived experiences of older adults living with HIV in Hong Kong. Twenty older Chinese adults of age 50 or above will be recruited from an HIV specialist clinic providing HIV care in the…
- Trial name
- NCT05021653
- Testing
- no intervention
- Where
- Hong Kong
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Major Depression
Comparing Engage to PST for Late Life Depression
This is a non-inferiority trial of Engage, a new intervention for late-life depression, and problem solving therapy (PST). Patient participants will be randomized to either Engage or PST and receive 9 weeks of either…
- Trial name
- Engage (NCT02086201)
- Testing
- Problem Solving Therapy, Engage
- Where
- 2 sites in United States
- Volunteers
- 262 people
- Sponsor
- University of Washington
Depression, Suicide
Intranasal Ketamine for Late-Life Depression and Suicidal Ideation
The investigators of this study plan to investigate the feasibility and efficacy of repeated doses of intranasal ketamine in severely depressed patients who are at least 65 years of age and experiencing suicidal ideation.
- Conditions
- Depression, Suicide, Suicidal Ideation
- Trial name
- NCT02295787
- Testing
- Ketamine
- Sponsor
- Massachusetts General Hospital
Generalized Anxiety Disorder
Cognitive Behavioral Therapy (CBT) for Late Life Anxiety
The purpose of this research study is to assess the acceptability and feasibility of the implementation strategy and fidelity of cognitive-behavioral therapy (CBT) for older adults with Generalized Anxiety Disorder.
- Trial name
- NCT05380115
- Testing
- Cognitive Behavioral Therapy (CBT)
- Sponsor
- Wake Forest University Health Sciences
Learning; Lack of (Specific), Depression
Nano-Learning for Improving Compliance Among Older Adults With Sarcopenia
Empirical evidence suggests that the use of short videos is associated with decreased feelings of loneliness and social isolation, thereby reducing depression among older adults .
- Conditions
- Learning; Lack of (Specific), Depression, Older Adults, Sarcopenia
- Trial name
- NCT07185763
- Testing
- Nano-Learning interventional program
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Parenteral Nutrition, Home
Evaluation of a Connected Parenteral Pump for Patients Treated by Home Parenteral Nutrition (HPN).
Patients requiring long-term home parenteral nutrition (HPN) suffer from chronic intestinal insufficiency. The causes of this syndrome can be either anatomical (extensive resection of the small bowel) or functional (occlusion…
- Trial name
- SERENE-eNUTRI (NCT04406766)
- Testing
- Connected nutrition pump system
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Grenoble
Late Life Depression
Explore the Neural Mechanism of Mindfulness Training to Reduce Loneliness in Depressed Older Adults
Perceived loneliness causes a global health burden on older adults. Mindfulness training may be a feasible solution. Through our study, we expect that comprehensive and convincing neuroscientific evidence may support the efficacy…
- Trial name
- NCT05620511
- Testing
- Mindfulness based stress reduction
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Major Depressive Disorder
Deep rTMS for Depression in Older Adults
This study aims to: (1) assess the feasibility and tolerability of two active dTMS coils - H4 and H7 - in older adults with depression; and (2) clinical response measured by change from baseline on the Hamilton Depression Rating…
- Trial name
- NCT05855850
- Testing
- Brainsway H4-Coil Deep TMS System, Brainsway H7-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Non Hodgkin Lymphoma, DLBCL
Cardiotoxicity and Other Late Effects After Radiotherapy and Immuno-chemoTherapy in Non-Hodgkin lYmphoma
Survivors of non-Hodgkin lymphoma and a control group will be screened for (sub)clinical cardiovascular disease, to assess the influence of contemporary treatments on risk and burden of (sub)clinical cardiovascular disease and…
- Conditions
- Non Hodgkin Lymphoma, DLBCL, Cardiovascular Diseases, Cardiomyopathies
- Trial name
- CLARITY (NCT07041827)
- Testing
- Cardiovascular assessment
- Where
- Netherlands
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Alzheimer´s Disease, General Anesthesia
Is There a Relationship Between Previous Exposure to General Anesthesia and the Development of Alzheimer´s Disease?
The purpose of this study is to compare exposure to general anesthesia between cases with a diagnosis of Alzheimer´s disease and controls without diagnosis, through studies of medical records.
- Trial name
- DEMA (NCT01695889)
- Where
- Sweden
- Volunteers
- 877 people
- Sponsor
- University Hospital, Linkoeping
Bladder Cancer
The Impact of Late Effects After Treatment for Bladder Cancer on Quality of Life
Bladder Cancer prognosis, treatment, and subsequent morbidity and mortality vary between the different stages, thus resulting in a different impact on patients' lives.
- Trial name
- CONQUER (NCT05195515)
- Where
- 5 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Aarhus University Hospital
Prolonged Grief Disorder
Mechanisms Underlying Late-Life Prolonged Grief Disorder
After losing a loved one, most successfully navigate acute grief and adapt to the loss within about 1 year, but in about 10%, prolonged grief disorder (PGD) ensues.
- Trial name
- NCT07738133
- Testing
- Iyengar Yoga, Health Education Control, Waitlist Control to Crossover
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Medical College of Wisconsin