Clinical trials: Later Life
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Electroconvulsive Therapy Amplitude Titration
This study is focused on advancing ECT treatment for older adults with depressive disorders by refining neuromodulation stimulus parameters to improve efficacy and cognitive safety.
- Trial name
- NCT04621786
- Testing
- Mecta Spectrum 5000Q paired with Soterix Medical 4X1 HD - ECT Multi-Channel Stimulation Interface
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of New Mexico
Aging
Resveratrol and Exercise to Treat Functional Limitations in Late Life
The purpose of this research study is to evaluate the effects of combining physical exercise with a resveratrol supplementation on the physical function of older adults.
- Trial name
- NCT02523274
- Testing
- Resveratrol, Exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Depression, Anxiety Disorder
Preventing Depression in Late Life: A Model for Low and Middle Income Countries
This study is being conducted in GOA India. The study addresses specific issues of depression prevention in older adults living in low- and middle income countries (LMICs), by developing risk-reduction strategies through the use…
- Trial name
- NCT02145429
- Testing
- Problem Solving therapy and Brief Behavioral Treatment of Insomnia
- Where
- India
- Volunteers
- 181 people
- Sponsor
- University of Pittsburgh
Anxiety Disorders Generalized
A Pilot fMRI Study of TMS in Late-Life Severe Worry
Investigators will test a novel intervention through experimental therapeutic approach using fMRI-directed Intermittent Theta Burst Stimulation (iTBS), a high frequency TMS paradigm, for the treatment of severe, uncontrollable…
- Trial name
- TINA (NCT03577106)
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Carmen Andreescu
Anxiety Disorders, Generalized Anxiety Disorder
Drug Therapy for Generalized Anxiety Disorder Among the Elderly
This study will determine the efficacy of escitalopram (Lexapro®), an anti-anxiety drug, for generalized anxiety disorder (GAD) and the ways genetics affect response to treatment for GAD in elderly individuals.
- Trial name
- NCT00105586
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Pittsburgh
Depression Mild, Depressive Disorder, Major
Cognitive Fitness for Depression in Older Adults
This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants.
- Conditions
- Depression Mild, Depressive Disorder, Major, Mild Cognitive Impairment
- Trial name
- NCT04790630
- Testing
- Computerized Cognitive Remediation of Executive Functioning (CCR-EF), Active Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- UConn Health
Respiratory Syncytial Virus Infections
A Study to Evaluate the Safety and Efficacy of MEDI8897 for the Prevention of Medically Attended Lower Respiratory Tract Infection Due to Respiratory Syncytial Virus in Healthy Late Preterm and Term Infants (MELODY)
The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics (PK), and antidrug antibody (ADA) response for MEDI8897 in healthy late preterm and term infants who are 35 weeks or greater gestational age and…
- Trial name
- MELODY (NCT03979313)
- Testing
- MEDI8897
- Where
- 198 sites in United States, Argentina and 29 more
- Volunteers
- 3,012 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Anxiety Disorders
Relaxation Treatment for Anxiety in Adults Aged 60 or Older
The PI developed a self-directed program to treat late-life anxiety called Breathing, Relaxation, and Education for Anxiety Treatment in the Home Environment (BREATHE).
- Trial name
- BREATHE (NCT02429778)
- Testing
- Diaphragmatic Breathing, Progressive Muscle Relaxation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Palo Alto Veterans Institute for Research
Major Depressive Disorder
A Study Comparing the Efficacy and Safety of Duloxetine and Placebo for the Treatment of Depression in Elderly Patients
The purpose of this study is to compare the efficacy and safety of duloxetine 60 mg once daily to placebo on depression in elderly patients (greater than or equal to 65 years of age).
- Trial name
- NCT00406848
- Testing
- duloxetine hydrochloride
- Where
- 33 sites in United States, France and 2 more
- Volunteers
- 370 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression
The long-term goal of this line of research is to determine if decreased vascular reactivity and frontal hypoperfusion is associated with poor response antidepressants.
- Trial name
- NCT01896934
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University
Depression
Buprenorphine for Late-Life Treatment Resistant Depression
The goals of this pilot study are to gather data about the safety and clinical effect of low-dose buprenorphine in older adults with treatment resistant depression.
- Trial name
- BUILD (NCT01071538)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Depression, Hypertension
Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression
This pilot proposal will test the hypothesis that altered cerebral vessel reactivity and cerebral hypoperfusion (decreased blood flow to the brain) is a core mechanism underlying the relationship between vascular disease and…
- Trial name
- NCT01794455
- Testing
- Sertraline, Candesartan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University
Treatment Resistant Depression, Refractory Depression
Ketamine for Older Adults Pilot
This pilot study will assess the safety and feasibility of intravenous (IV) ketamine in older adults with Treatment-Resistant Depression (TRD).
- Conditions
- Treatment Resistant Depression, Refractory Depression, Therapy-Resistant Depression, Late Life Depression
- Trial name
- NCT04504175
- Testing
- Ketamine
- Where
- 5 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder, Depression
Buprenorphine Used With Treatment Resistant Depression in Older Adults
The investigators are conducting a research study to learn about the safety and benefit of using a medication called buprenorphine for patients with difficult to treat depression.
- Trial name
- IRLGreyB (NCT02181231)
- Testing
- venlafaxine XR, buprenorphine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Depression, Suicidal Ideation
Social Connections and Late Life Suicide
With the long-term goal of improving interventions for late-life suicide, the purpose of this study is to examine whether a mechanism by which behavioral interventions reduce risk for late-life suicide is by increasing social…
- Trial name
- NCT02188485
- Testing
- ENGAGE
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Rochester
Mild Cognitive Impairment, Amnestic Mild Cognitive Impairment - aMCI
Cognitive Outcomes of Brain Stimulation As a Later-in-Life Treatment
This is a pilot study being done to attempt to improve episodic memory problems in persons with mild cognitive impairment (MCI).
- Trial name
- COBALT (NCT05564715)
- Testing
- NeuroElectric StarStim
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Texas Southwestern Medical Center
Depression, Dementia
Antidepressant Medication Plus Donepezil for Treating Late-life Depression
This study will determine the effectiveness of combining escitalopram, venlafaxine, or duloxetine with donepezil, a medication used in Alzheimer's disease, in improving memory, concentration, attention, and problem solving…
- Trial name
- NCT00177671
- Testing
- Escitalopram, Donepezil, Venlafaxine
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Generalized Anxiety Disorder
Telephone Psychotherapy for Late-Life Generalized Anxiety Disorder (GAD)
The purpose of this study is to determine if cognitive-behavioral therapy (CBT)and supportive therapy delivered by telephone are effective for reducing worry and anxiety in rural older adults with Generalized Anxiety Disorder…
- Trial name
- NCT01259596
- Testing
- cognitive behavioral therapy, nondirective supportive therapy
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Wake Forest University Health Sciences
Post Traumatic Stress Disorder
Post-traumatic Stress Disorder (PTSD) Symptoms in Later Life
Older adults are becoming a growing proportion of people utilising mental health services. However, the needs of this population are poorly understood despite the evidence that mental health conditions are manifested differently…
- Trial name
- NCT03821259
- Testing
- Psychological measures
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- University of Edinburgh