Clinical trials: Leakage, Anastomotic
Rectal Cancer
Multi-Technology Integrated Total Mesorectal Excision Versus Conventional Total Mesorectal Excision for the Treatment of Middle and Distal Rectal Cancer.
A multicenter, prospective, randomized, controlled clinical trial of multi-technology integration total mesorectal excision (MTI-TME) versus conventional total mesorectal excision (C-TME) for the treatment of middle and distal…
- Trial name
- NCT06613399
- Testing
- MTI-TME, C-TME
- Volunteers
- 324 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Anastomotic Leaks, Hartmanns Stump Leakage
Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area
This study is intended to evaluate the safety and effectiveness of Sponge-based Endoscopic Vacuum Therapy (EVT) using Endo-SPONGE for the treatment of Anastomotic Leaks (AL) or Hartmann's stump leakages following colorectal…
- Trial name
- DRAIN Lower (NCT07035431)
- Testing
- Endo-SPONGE
- Where
- 10 sites in United States
- Volunteers
- 66 people
- Sponsor
- Boston Scientific Corporation
Colorectal Surgery, Anastomotic Leak Rectum
VACStent Use for the Treatment of Anastomotic Leakage Following coloREctal Surgery
Introduction: Anastomotic leakage (AL) is the most severe complication following colorectal surgery and is associated with significant morbidity and mortality.
- Conditions
- Colorectal Surgery, Anastomotic Leak Rectum, Endoscopy, Digestive System, Vacuum Therapy
- Trial name
- VACURE (NCT07631702)
- Testing
- VacStent GI Colon device
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Anastomosis, Perfusion
PPG vs. ICG in Gastrointestinal Resections
This randomized controlled trial compares a novel optical technique against the standard of care for assessing tissue perfusion in gastrointestinal surgery.
- Conditions
- Anastomosis, Perfusion, Postoperative Complications, Gastrointestinal Neoplasms
- Trial name
- NCT06222645
- Testing
- ICG fluorescence imaging technology, Imaging Photoplethysmography System
- Where
- 3 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Saint Petersburg State University, Russia
Colon Cancer
Intracorporeal Versus Extracorporeal Anastomotic After Laparoscopic Right Colectomy
Background: Laparoscopic assisted right hemicolectomy is recommended for right colon cancer. As a more minimally invasive procedure, intracorporeal ileocolic anastomosis has potential advantages: reducing torsion and traction on…
- Trial name
- NCT05493033
- Testing
- Intracorporeal anastomotic after LRC, Extracorporeal anastomotic after LRC
- Volunteers
- 1,158 people
- Sponsor
- Beijing Friendship Hospital
Rectal Cancer Patients, Anastomotic Leakage
CRP/CT-Guided Selective Ileostomy After LAR
This single-center, parallel-group randomized controlled trial compared routine diverting loop ileostomy with a postoperative CRP/CT-guided selective ileostomy strategy in adults undergoing laparoscopic low anterior resection for…
- Conditions
- Rectal Cancer Patients, Anastomotic Leakage, Low Anterior Resection
- Trial name
- less stoma (NCT07722533)
- Testing
- Serial C-reactive protein-guided computed tomography surveillance and selective omission of defunctioning ileostomy, routine follow up
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Alexandria University
Colorectal (Colon or Rectal) Cancer, STOMACH NEOPLASM
Perioperative Biomarkers in Colorectal and Gastric Cancer Surgery
This study aims to evaluate whether monitoring perioperative inflammatory and metabolic biomarkers can help identify postoperative complications early in adult patients undergoing colorectal or gastric cancer surgery.
- Trial name
- PERIO-BIO (NCT07881133)
- Testing
- Perioperative Biomarker-Guided Monitoring
- Where
- Romania
- Volunteers
- 320 people
- Sponsor
- Bucharest Emergency Hospital
Rectum Cancer, Faecal Incontinence
Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.
The occurrence of colorectal cancer has increased from the third most common cancer in 2018 to the second most common cancer in 2023.
- Conditions
- Rectum Cancer, Faecal Incontinence, Faecal Incontinence with Faecal Urgency, Low Anterior Resection Syndrome
- Trial name
- NCT06601985
- Testing
- J-pouch anastomosis, direct anastomosis
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai 10th People's Hospital
Gastrointestinal Cancer, Colorectal Cancer
Microbiome Analysis in esoPhageal, PancreatIc and Colorectal CaNcer Patients Undergoing Gastrointestinal Surgery
The MA-PPING is a multicenter prospective observational study that includes patients undergoing surgery for gastrointestinal cancer.
- Conditions
- Gastrointestinal Cancer, Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer
- Trial name
- MA-PPING (NCT04189393)
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Esophageal Anastomotic Leak, Tissue Pressure of Oxygen
Ischemic Conditioning of the Gastric Conduit in Esophageal Cancer.
This study is a randomized clinical trial to clarify if preoperative embolization of gastric arteries can reduce the incidence of oesophagogastric leakage after an esophagectomy for esophageal cancer comparing an experimental…
- Trial name
- NCT04268654
- Testing
- Preoperative Arterial Embolization
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Anastomotic Leak, Gastric Cancer
Anastomotic Leak Testing in Gastrectomy
Anastomotic leak after radical gastrectomy is a serious complication. Intraoperative leak testing was often used to assess the integrity of the anastomosis.
- Conditions
- Anastomotic Leak, Gastric Cancer, Surgery, Testing, Reality
- Trial name
- NCT04292496
- Testing
- Introperative leak testing
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Nanchong Central Hospital
Enhanced Recovery After Surgery, Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge
Resumption of Enteral Feeding After Bowel Anastomosis
Resumption of oral feeding after small intestine surgery is a matter of controversy .Some surgeons advocate early resumption while others don't.early feeding is initiated as soon as the patient recovers from effects of…
- Conditions
- Enhanced Recovery After Surgery, Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge, Defecation, Vomiting, Postoperative
- Trial name
- NCT06906289
- Testing
- resumption of enteral feeding within 24 hours of surgery, resumption of enteral feeding after 24-48 hours
- Where
- Pakistan
- Volunteers
- 204 people
- Sponsor
- Khyber Teaching Hospital
Rectal Cancer, Anastomotic Leakage
Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior Resection
The goal of this clinical trial is to learn if somatostatin plus a clear liquid diet can help prevent severe leakage after rectal cancer surgery in adults with low or mid rectal cancer who are scheduled to have ultra-low anterior…
- Trial name
- SC-Stoma (NCT07605611)
- Testing
- Somatostatin, Clear Liquid Diet, Prophylactic Diverting Stoma
- Where
- 3 sites in China
- Volunteers
- 72 people
- Sponsor
- Tongji Hospital
Anastomotic Leaks
Study of Eso-SPONGE for Treating Leaks After Upper Gastrointestinal Surgery
To evaluate the safety and effectiveness of sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE for the treatment of anastomotic leaks in the upper gastrointestinal tract in a prospective multi-center study.
- Trial name
- DRAIN Upper (NCT07711093)
- Testing
- sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Boston Scientific Corporation
Rectal Neoplasms
Perfusion Outcomes With Near Infrared-Indocyanine Green Imaging System in Laparoscopic Total Mesorectal Excision for Mid- or Low-rectal CanceR
It is a multicenter, prospective, and randomized controlled clinical study of patients with mid- or low- rectal cancer who received laparoscopic TME surgery aims to explore whether the application of near infrared-indocyanine…
- Trial name
- POSTER (NCT04012645)
- Testing
- application of near infrared-indocyanine green imaging system, Non-application of near infrared-indocyanine green imaging system
- Where
- 2 sites in China
- Volunteers
- 547 people
- Sponsor
- Zhongtao Zhang
Anastomotic Leak
Neutrophil-to-lymphocyte Ratio vs C-reactive Protein as Early Predictors of Anastomotic Leakage After Colorectal Surgery
Introduction: Colorectal surgery (CRS) is associated with high morbidity rates, being anastomotic leakage (AL) one of the most serious complications with an incidence as high as 15%, accounting for up to a third of mortality in…
- Trial name
- NCT04673110
- Testing
- Neutrophil to Lymphocyte Ratio and C-reactive protein
- Volunteers
- 116 people
- Sponsor
- Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba
Hyperglycaemia, Total Gastrectomy
The Effect of Perioperative Hyperglycemia on Anastomotic Leaks After Total Gastrectomy
Esophagojejunostomy anastomosis is used in total gastrectomy surgeries. Anastomotic leakage is a serious complication seen after these surgeries and is associated with increased morbidity and mortality.
- Conditions
- Hyperglycaemia, Total Gastrectomy, Anastomotic Leaks
- Trial name
- NCT07140991
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Taner Abdullah
Anastomotic Leakage
The Optimal Width of Gastric Conduit for Minimally Invasive Esophagectomy: Wide or Narrow?
The study hypothesized that a narrow gastric conduit(less than 3cm in width) would minimize anastomotic leakage following minimally invasive esophagectomy.
- Trial name
- NCT01696682
- Testing
- Narrowed Gastric Conduit, Widened Gastric Conduit
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Anastomotic Leak
Prevention of Anastomotic Leak in Gastrointestinal (GI) Anastomosis With the Application of Tisseal in the Anastomotic Line
The anastomotic leak is one of the most feared complications in abdominal surgery. Certain control methods have been described but the incidence of that complication remains high and is the first cause of mortality in operations…
- Trial name
- NCT01306851
- Testing
- Fibrin glue
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Perforation Esophagus, Esophageal Cancer
Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent)
Open, prospective, one-arm feasibility and efficacy study of a European conformity (CE) certified Combination product of two CE certified medical devices in the intended indication.
- Conditions
- Perforation Esophagus, Esophageal Cancer, Esophageal Achalasia, Esophageal Diseases
- Trial name
- VACStent (NCT03962179)
- Testing
- VACStent
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital of Cologne