Clinical trials: Learning and Memory
Brain Diseases, Memory Disorders
Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation
The goal of this clinical trial is to investigate the impact of low intensity focused ultrasound pulsation (LIFUP) to two different brain regions, the amygdala and entorhinal cortex, in older adults.
- Conditions
- Brain Diseases, Memory Disorders, Learning Disabilities, Cognitive Impairment
- Trial name
- LIFUPMEMEMOT (NCT03717922)
- Testing
- Low Intensity Focused Ultrasound Pulsation to Amygdala, Low Intensity Focused Ultrasound Pulsation to Entorhinal Cortex
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention in High-Fidelity Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- LABYR (NCT04253587)
- Testing
- LabyrinthVR, Coherence, Tablet
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression, Major Depressive Disorder
Reward Emotion Learning and Ketamine Study
Ketamine's efficacy as an antidepressant is now well established yet the mechanisms underlying its antidepressant effect are yet to be fully described.
- Conditions
- Depression, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- RELAKS (NCT04850911)
- Testing
- Ketamine Hydrochloride
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Multiple Sclerosis
Modafinil in Multiple Sclerosis
Deficits in new learning and memory in MS are a major complaint of patients, and have been noted to be a significant contributor to disability by numerous researchers.
- Trial name
- NCT00142402
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Opioid Use Disorder, Healthy
Adversity, Brain and Opioid Use Study
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms.
- Trial name
- NCT06355778
- Testing
- Magnetic Resonance Imaging (MRI), Computer Tasks
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Apnea
Sleep Apnea and Visual Perceptual Skill Learning
The purpose of this study is to determine whether obstructive sleep apnea affects sleep dependent memory and learning. Subjects with apnea will be given a test of perceptual skill learning (the Visual Discrimination Task (VDT))…
- Trial name
- NCT01852929
- Testing
- Subject using usual positive airway pressure therapy while sleeping for one night
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Heidi Roth, MD
Autism
Effects of Hyperbaric Oxygen Therapy on Children With Autism
PURPOSE The purpose of this investigation is to evaluate the cognitive and behavioral effects of Hyperbaric Oxygenation Therapy in children who present with a diagnosis of autism spectrum disorder. HYPOTHESIS 1.
- Trial name
- NCT00406159
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thoughtful House
PTSD
Cognitive Processing Therapy (CPT) Memory Support (MS) Study
The efficacy of psychological interventions for posttraumatic stress disorder (PTSD) is likely limited by the difficulty participants have learning and remembering important therapy content.
- Trial name
- NCT05310097
- Testing
- CPT, MS
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston University
Schizophrenia
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights.
- Trial name
- NCT06386588
- Testing
- Closed loop auditory stimulation during sleep
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Relapsing Remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis
Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis
Noninvasive brain stimulations (NIBS) will be used in MS patients with cognitive impairments to enhance their cognitive aptitudes.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis, Cognitive Deficits, Motor Deficits
- Trial name
- MScog-tDCS (NCT02266121)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Aging
The Entorhinal Cortex and Aerobic Exercise in Aging
The overall goal of this study is to examine how regular exercise affects brain function, spatial memory, and virtual navigation. Participation in this research study will take approximately 4 months.
- Trial name
- ECE (NCT02775760)
- Testing
- Cardiovascular endurance, Strength, balance, and flexibility
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Boston University
Chronic Kidney Disease
Exercise Trial in Chronic Kidney Disease
Chronic Kidney Disease (CKD) is exceedingly common in older adults, in whom it is associated with impairment in cognition and physical function.
- Trial name
- AWARD (NCT01462097)
- Testing
- Aerobic exercise training, Health Education
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- University of Maryland, Baltimore
TBI (Traumatic Brain Injury) or MS (Multiple Sclerosis)
Improving Learning in Hispanics With TBI or MS
The goal of this study is to establish that a memory retraining protocol, originally developed for English-speakers, and translated into Spanish, is effective.
- Trial name
- NCT03453125
- Testing
- Spanish modified Story Memory Technique (mSMT)
- Where
- 2 sites in United States, Spain
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Cognitive Performance, Academic Performance
Acute Effects of Active Breaks and Physically Active Learning in University Students
This multicenter randomized crossover study will examine the acute effects of four classroom break conditions on executive functions, immediate academic performance, perceived exertion, and interest-enjoyment in university…
- Trial name
- PAL UNI (NCT07809750)
- Testing
- Sedentary Academic Review, Active Break, Physically Active Learning
- Where
- Spain
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Healthy Children, Preterm Birth
Executive Training and Brain in Children
The purpose of this study is to determine whether a daily executive training to cognitive inhibition, working memory or mindfulness as compared to an active control condition has a near- and far-transfer impact on brain and…
- Trial name
- APEX (NCT02989116)
- Testing
- Inhibition training, Working memory training, Mindfulness training
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Attention Deficit Disorder
Working Memory Training in College Students With Attention-Deficit Hyperactivity Disorder/Learning Disabilities
The overall objective of the current study is to determine whether computerized Working Memory (WM) training will enhance WM capacity in college students with Attention Deficit Hyperactivity Disorder (ADHD)/Learning Disabilities…
- Trial name
- NCT01154686
- Testing
- Cogmed
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Toronto
Multiple Sclerosis
Improving Learning and Memory in Portuguese Patients With Multiple Sclerosis
Deficits in memory and learning are common in Multiple Sclerosis, posing significant challenges in patients' daily lives. Cognitive rehabilitation has been shown to be effective in ameliorating these deficits, with programs such…
- Trial name
- NCT06723444
- Testing
- Learning and Memory Training
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Memory, Learning
Losartan and Emotional Memory
This study explores the effects of single-dose losartan (50mg) versus identical placebo capsule on emotional memory and learning in healthy volunteers.
- Trial name
- NCT03763409
- Testing
- Losartan Potassium
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Parkinson's Disease, Mild Cognitive Impairment
A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease
This randomized, controlled trial (RCT) evaluates the benefits of memory and problem solving training compared to supportive therapy in individuals with Parkinson's Disease with Mild Cognitive Impairment (MCI) and their support…
- Trial name
- NCT01646333
- Testing
- Memory and Problem-Solving Intervention, Supportive Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Virginia Commonwealth University
Anxiety
Influence of Anxiety on Motor Learning and Motor Imagery Ability in Young Population
In motor learning, to consider that movements are produced by the cooperation and combination of many brain structures and are influenced by the emotions to which individuals are subjected is essential.
- Trial name
- NCT04973956
- Testing
- Relaxation, Control
- Where
- 4 sites in France, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Susana Nunez Nagy