Clinical trials: Left Heart Failure
Heart Failure
Identifying and Facilitating Ventricular Recovery on Mechanical Support
Heart failure is a progressive disorder in which the weakened heart is not able to efficiently pump blood throughout the body. When the body's cells do not receive enough blood, this can result in fatigue, shortness of breath…
- Trial name
- RECOVER (NCT00687856)
- Testing
- Echocardiogram (echo)
- Where
- 5 sites in United States
- Volunteers
- 211 people
- Sponsor
- University of Pittsburgh
Left Sided Heart Failure
Effect of Left Ventricle Diastolic Dysfunction on Outcomes in Female Cardiac Surgery Patients
The aim of this study is to evaluate the differences between males and females with LVDD, undergoing cardiac surgery. The investigators will look at perioperative factors such as body weight, body surface area, previous medical…
- Trial name
- EDISON (NCT05972356)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Heart Failure, Heart Murmurs
Retrospective Evaluation of Carvedilol Versus Captopril in CHF Patients
This is a retrospective chart review examining our experience with carvedilol in CHF secondary to left-to-right heart shunt lesions. The treatment group will be children who have received carvedilol.
- Trial name
- NCT00249067
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Healthcare of Atlanta
Heart Failure
Corheart 6: Long-term Cohort Study
This study aims to evaluate the long-term effectiveness and safety of Corheart 6 left ventricular assist system as a treatment for patients with advanced left heart failure.
- Trial name
- NCT07094919
- Testing
- Corheart 6 left ventricular assist system
- Where
- 8 sites in China
- Volunteers
- 160 people
- Sponsor
- China National Center for Cardiovascular Diseases
Left Ventricular Insufficiency
Safety Study of Chimeric Natriuretic Peptide(CD-NP) in Stable LVAD Patients
The most promising chimeric natriuretic peptide designed and studied by our group has been CD-NP which has anti-fibrotic and cardioprotective properties in vivo, vitro and in normal volunteers and human heart failure patients.
- Trial name
- NCT01750905
- Testing
- CD-NP
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Chronic Renal Failure
EPO-BUL-01 - Study of the Optimization of Anemia Management of EPREX (Epoetin Alfa) in Predialysis Patients With Chronic Renal Failure
The purpose of the study is to evaluate the effectiveness, safety and clinical outcome of Epoetin alfa with dosing regime in accordance with Summary of Product Characteristics in the treatment of anemia in predialysis.
- Trial name
- NCT00338000
- Testing
- Epoetin alfa
- Volunteers
- 292 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Heart Failure, Systolic
Patient Reported Outcomes inVestigation Following Initiation of Drug Therapy With Entresto (Sacubitril/Valsartan) in Heart Failure
Real-world evidence of the clinical course of patient symptoms following initiation of sacubitril/valsartan via PROs with a patient-centered study design will provide important evidence of potentially beneficial outcomes…
- Trial name
- PROVIDE-HF (NCT03387163)
- Testing
- Sacubitril/Valsartan
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease, Heart Failure Systolic
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing…
- Trial name
- NCT05427370
- Testing
- Revascularization by PCI, Revascularization by CABG
- Where
- 46 sites in United States, Austria and 14 more
- Volunteers
- 754 people
- Sponsor
- Sunnybrook Health Sciences Centre
Heart Failure With Reduced Ejection Fraction, Left Bundle Branch Area Pacing
Left Bundle Branch Area Pacing in Patients With Heart Failure
The relevance of Left Bundle Branch Pacing (LBBP) lies in its potential as a promising treatment option for patients with heart failure and left bundle branch block.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Left Bundle Branch Area Pacing, Heart Failure, Cardiac Resynchronization Therapy
- Trial name
- LBBAPHF (NCT06488989)
- Testing
- left bundle branch area pacing
- Where
- Kazakhstan
- Volunteers
- 50 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Congestive Heart Failure, Type II Diabetes Mellitus
Effect of Vildagliptin on Left Ventricular Function in Patients With Type 2 Diabetes and Congestive Heart Failure
This study will assess the effect of vildagliptin on left ventricular function in patients with type 2 diabetes and congestive heart failure (NYHA Class I-III).
- Trial name
- NCT00894868
- Testing
- vildagliptin
- Where
- 93 sites in Czechia, Denmark and 13 more
- Volunteers
- 798 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Comparative Effects of Nebivolol and Carvedilol on Diastolic Function in the Elderly Heart Failure Patients
Heart failure (HF) is a common and disabling condition in the elderly. Randomized clinical trials and meta-analyses have clearly demonstrated that long-term use of β blockers improves the outcomes of patients with HF.
- Trial name
- NCT02619526
- Testing
- Nebivolol, Carvedilol
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Dong-A University
End-stage Renal Disease, Left Ventricular Hypertrophy
Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease
Background: Recent data indicate that home nocturnal hemodialysis (8 hours of hemodialysis at home for 5-6 nights per week) may have substantial cardiovascular benefits, including regression of left ventricular (LV) hypertrophy…
- Trial name
- NCT00718848
- Testing
- Incentre nocturnal hemodialysis, Remaining on conventional hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction
CASTLE-HFpEF (Catheter Ablation for Atrial Fibrillation Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction)
The clinical equipoise in the treatment of Atrial Fibrillation (AF) in patients with Heart Failure with mildly reduced Ejection Fraction/Heart Failure with Preserved Ejection Fraction (HFmrEF/HFpEF) reflects the scarcity of…
- Trial name
- NCT07254455
- Testing
- Catheter ablation
- Volunteers
- 900 people
- Sponsor
- Tulane University
End Stage Renal Disease, Left Ventricular Hypertrophy
Does ALlopurinol Regress lefT Ventricular Hypertrophy in End Stage REnal Disease: The ALTERED Study
Kidney patients on dialysis commonly die because of heart disease. One of the biggest problems in their hearts is that the muscle wall of the heart thickens. This makes it less efficient.
- Trial name
- Altered (NCT01951404)
- Testing
- Allopurinol
- Where
- 3 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Dundee
Dilated Cardiomyopathy
Reverse Remodelling and Remission Markers in the Serial Evaluation of Recent-onset Dilated Cardiomyopathy
Approximately 30-40% of patients with non-ischaemic dilated cardiomyopathy (DCM) undergo significant left ventricular reverse remodelling in response to guideline-directed therapies.
- Trial name
- REMIT-DCM (NCT04957147)
- Testing
- 12 months of guideline-directed heart failure therapy
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Heart Failure, Cardiomyopathy
Safety & Efficacy of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in LVAD Recipients
The main purpose of this research is to determine whether injecting mesenchymal precursor cells (MPC) into the heart during surgery to implant a left ventricular assist device (LVAD) is safe.
- Conditions
- Heart Failure, Cardiomyopathy, Ventricular Dysfunction
- Trial name
- NCT02362646
- Testing
- MPC Intramyocardial Injection, Control Solution
- Where
- 19 sites in United States, Canada
- Volunteers
- 159 people
- Sponsor
- Annetine Gelijns
Dilated Cardiomyopathy
The Influence of Atorvastatin on the Parameters of Inflammation and the Function of Left Ventricle
The aim of the study was to assess of the influence of atorvastatin on selected indicators of an inflammatory condition, function of the left ventricle and factors affecting the occurrence of undesired events like…
- Trial name
- NCT01015144
- Testing
- Tulip
- Sponsor
- Medical University of Lodz
Breast Neoplasm Female, Lymphoma
Cancer Adverse Effects PReventIon With Care & Exercise: the CAPRICE Study
Breast cancer is the most common cancer among women worldwide. Similarly, Hodgkin and non- Hodgkin lymphomas make up two of the most prevalent cancers in men and women.
- Conditions
- Breast Neoplasm Female, Lymphoma, Cardiotoxicity, Anthracyclines
- Trial name
- NCT03850171
- Testing
- Exercise Training
- Where
- 4 sites in Switzerland
- Volunteers
- 57 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Left Ventricular Non-compaction Cardiomyopathy, Left Ventricular Failure
Value of Cardiac Magnetic Resonance (CMR) Derived Parameters for Diagnosing Left Ventricular Non-compaction Cardiomyopathy
Left ventricular non-compaction (LVNC) is a rare cardiomyopathy characterized by numerous excessively prominent left ventricular (LV) trabeculation and deep intertrabecular recesses communicating with the ventricular cavity and…
- Conditions
- Left Ventricular Non-compaction Cardiomyopathy, Left Ventricular Failure, Left Ventricular Hypertrophy
- Trial name
- NCT01481298
- Where
- Germany
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Heart Failure
Model 4196 Left Ventricular (LV) Lead Chronic Performance Study
The purpose of this study is to evaluate long-term performance of the 4196 LV Lead. This evaluation is based on the number of lead-related complications occurring during the study compared to the number of leads enrolled in the…
- Trial name
- NCT00930904
- Where
- 103 sites in United States, Austria and 6 more
- Volunteers
- 1,847 people
- Sponsor
- Medtronic