Clinical trials: Left Heart Failure
CRT Non-Response, LBBB
Left Ventricular Myocardial Work for Predicting Response to CRT
This study aims to establish the normal reference values for left ventricular myocardial work in healthy Chinese adults and the influencing factors.
- Conditions
- CRT Non-Response, LBBB, HF - Heart Failure, Healthy Adult
- Trial name
- CARE-MW (NCT07319065)
- Testing
- Ultrasound machine
- Where
- 82 sites in China
- Volunteers
- 3,240 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Heart Failure
3D Assessment of RV Function in Patients Undergoing LVAD Implantation
This goal of this study is to analyze images of the right ventricle taken via 3D transesophageal echocardiography (TEE) during left ventricular assist device (LVAD) implantation.
- Trial name
- NCT05376254
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Aortic Valve Stenosis
Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate AS as compared with OHFT.
- Trial name
- NCT02661451
- Testing
- SAPIEN 3 THV, Optimal Heart Failure Therapy
- Where
- 51 sites in United States, Canada and 1 more
- Volunteers
- 178 people
- Sponsor
- Cardiovascular Research Foundation, New York
Cardiogenic Shock
Unloading in Heart Failure Cardiogenic Shock
The purpose of this research study is to evaluate whether timely and aggressive temporary Mechanical Circulatory Support (tMCS) through the Impella 5.5® in patients with acute decompensated heart failure complicated by…
- Trial name
- UNLOAD HF-CS (NCT05064202)
- Testing
- Impella 5.5, Inotropes
- Where
- 5 sites in Netherlands
- Volunteers
- 456 people
- Sponsor
- Amsterdam UMC, location VUmc
Right Heart Failure, Left Ventricular Assist Device
CRD-102 for Right Heart Failure in Patients With Left Ventricular Assist Devices
This is a Phase 1b/IIa, single centre, non-randomised open-label uncontrolled study to assess safety, effect and PK of oral CRD-102 in patients with RHF associated with the presence of an LVAD.
- Trial name
- NCT03217331
- Testing
- CRD-102
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cardiora Pty. Ltd.
Heart Failure
Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation
The goal of this clinical trial is to evaluate the effects of a home-based exercise program using mobile technology on physical activity and capacity, frailty and muscle mass, and quality of life in patients with a newly…
- Trial name
- MOVE-LVAD II (NCT06291922)
- Testing
- Exercise Intervention, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Heart Failure
Beta-blOckers discoNtinuation in Patients Presenting Heart FaIlure With REcovered Left Ventricular Ejection Fraction
A significant proportion of patients initially diagnosed with heart failure and a reduced left ventricular ejection fraction (LVEF<40%, HFrEF) presents a substantial improvement in response to evidence-based medical and device…
- Trial name
- BONFIRE (NCT06518694)
- Testing
- Βeta-Blockers discontinued (with tapering)
- Where
- France
- Volunteers
- 1,300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bradyarrhythmia, Atrioventricular Block
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period.
- Conditions
- Bradyarrhythmia, Atrioventricular Block, Left Bundle Branch Area Pacing
- Trial name
- NCT05585411
- Testing
- Left bundle branch area pacing, Right ventricular pacing
- Where
- 8 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- Yonsei University
Heart Failure
The Effects of Active VItamin D on Left Atrial Volume Index
This is a pilot feasibility study to determine the effects of an activated vitamin D compound (paricalcitol) on heart structure (size) and function (ability to relax) in patients with normal kidney function and a form of heart…
- Trial name
- AVID-LAVI (NCT01630408)
- Testing
- Paricalcitol
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Heart Failure, Left-sided
Cardio-vascular Energy Transfer and Ventriculo-arterial Coupling in Heart Failure
The goal of this pilot study is to investigate energy transfer fram the ventricle to the arteries in patients with heart failure, primary by investigating the total power.
- Trial name
- NCT06200246
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Hypertension, Vascular Diseases
- Trial name
- The PULSE-LHD (NCT07214376)
- Testing
- Pulmonary Artery Denervation (PADN)
- Where
- 18 sites in United States, China
- Volunteers
- 750 people
- Sponsor
- Pulnovo Medical, Inc.
Heart Failure, Congestive, Ventricular Dysfunction
Thoratec HeartMate II Left Ventricular Assist System (LVAS) for Destination Therapy
The purpose of this study is to determine the safety and effectiveness of the Thoratec HeartMate II Left Ventricular Assist System (LVAS) as Destination Therapy in end-stage heart failure patients who do not qualify for cardiac…
- Conditions
- Heart Failure, Congestive, Ventricular Dysfunction, Cardiomyopathies
- Trial name
- NCT00121485
- Testing
- Left Ventricular Assist System (LVAS)
- Where
- 47 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
Ventricular Dysfunction, Left, Hip Fracture
Preoperative levosimendán and Hip Fracture
The purpose of this study is to evaluate whether preoperative optimization with levosimendan in heart failure patients undergoing hip fracture surgery improves haemodynamic and tissue perfusion parameters.
- Trial name
- OPL (NCT02972918)
- Testing
- Levosimendan
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Hospital Universitario de Canarias
Mitral Valve Failure
NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation
Background: Transcatheter mitral valve replacement (TMVR) is recommended for some people with mitral valve heart problems. But the usual TMVR techniques might cause an obstruction for some people.
- Trial name
- NCT03015194
- Testing
- Edwards SAPIEN 3 transcatheter heart valve, ASHI INTECC Astato XS 20
- Where
- 6 sites in United States
- Volunteers
- 32 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Right-Sided, Cardiac Failure
Syncardia 50cc TAH-t as a Bridge to Transplant
The primary objective of the study is to evaluate whether the 50cc TAH-t can safely support, and provide probable benefit to, transplant-eligible pediatric patients (aged 10 - 18 years) and can safely and effectively support…
- Conditions
- Heart Failure, Right-Sided, Cardiac Failure, Heart Failure, Left-Sided
- Trial name
- NCT02459054
- Testing
- SynCardia 50cc temporary Total Artificial Heart (TAH-t)
- Where
- 26 sites in United States
- Volunteers
- 16 people
- Sponsor
- SynCardia Systems. LLC
Heart Failure
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Trial name
- NCT05651529
- Testing
- exogenous ketone salt supplement, exogenous carbohydrate supplement
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Heart Failure
Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction
This was a randomized, double-blinded, placebo-controlled, multiple-dose study in subjects with stable heart failure (HF) with reduced ejection fraction (HFrEF).
- Trial name
- NCT02788747
- Testing
- 4 mg elamipretide, 40 mg elamipretide
- Where
- 15 sites in Italy, Netherlands and 1 more
- Volunteers
- 71 people
- Sponsor
- Stealth BioTherapeutics Inc.
Heart Failure, Congestive, Dyspnea
Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF
Heart failure (HF) is a disease that is caused by a reduced heart muscle function. Reduced heart muscle function can occur as a consequence of reduced pumping activity from a weak heart muscle or because of a stiff heart muscle.
- Conditions
- Heart Failure, Congestive, Dyspnea, Pulmonary Edema
- Trial name
- NCT00505791
- Testing
- Nesiritide
- Where
- United States
- Sponsor
- University of Medicine and Dentistry of New Jersey
Heart Failure, Cardiac Resynchronization Therapy
LVSP Based CRT vs. RVAP Based CRT
To find out whether left ventricular septal pacing (LVSP)-based cardiac resynchronization therapy (CRT) is superior to right ventricular apical pacing (RVAP)-based CRT in patients with failed left bundle branch pacing at the…
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Ventricular Septal Pacing, Right Ventricular Septal Pacing
- Trial name
- NCT05985408
- Testing
- left ventricular septal pacing, right ventricular apical pacing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Asymptomatic Left Ventricular Systolic Dysfunction (Disorder), Heart Failure
ECG AI-Guided Screening for Low Ejection Fraction
This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of left ventricular systolic dysfunction.
- Trial name
- EAGLE (NCT04000087)
- Testing
- AI-enabled ECG-based Screening Tool
- Where
- United States
- Volunteers
- 358 people
- Sponsor
- Mayo Clinic