Clinical trials: Left Heart Failure
Heart Failure
Evaluation of the Jarvik 2000 Left Ventricular Assist System With Post-Auricular Connector--Destination Therapy Study
This investigation will be conducted as an interventional intention-to-treat clinical study in a population of end stage heart failure patients who meet specific inclusion and exclusion criteria.
- Trial name
- NCT01627821
- Testing
- Jarvik 2000 VAS, HeartMate II
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Jarvik Heart, Inc.
HF - Heart Failure
AI ECG Algorithm for Detecting LV Systolic Dysfunction
This prospective observational cohort study aims to evaluate the clinical performance of a deep learning-based electrocardiography (ECG) algorithm (DeepECG LVSD) for detecting left ventricular systolic dysfunction (LVSD), defined…
- Trial name
- NCT07636759
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Ajou University School of Medicine
Heart Failure
V-LAP™ Left Atrium Monitoring systEm for Patients With Chronic sysTOlic & Diastolic Congestive heaRt Failure
The purpose of the trial is to evaluate the safety, usability and performance of the V-LAP™ System in adult subjects with New York Heart Association (NYHA) Class III Heart Failure.
- Trial name
- VECTOR-HF (NCT03775161)
- Testing
- V-LAP™ System
- Where
- 2 sites in Germany, Italy
- Volunteers
- 45 people
- Sponsor
- Vectorious Medical Technologies Ltd.
Heart Failure, Left Bundle-Branch Block
Tailor-CRT: Better Application of Cardiac Resynchronization Therapy
Approximately one third of patients treated with cardiac resynchronization therapy (CRT) do not derive any clinical benefit. CRT response can be improved by tailoring LV lead placement and programming of atrio-ventricular (AV)…
- Trial name
- NCT02326493
- Testing
- Cardiac Resynchronization Therapy
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Maastricht University Medical Center
Heart Failure
Model 4396 Left Ventricular (LV) Lead Study
This study is designed to show that a new lead, which paces the left bottom chamber (left ventricle) of the heart, is safe and effective.
- Trial name
- 4396 (NCT00853593)
- Testing
- Pacing Lead
- Where
- 31 sites in United States, Australia and 6 more
- Volunteers
- 197 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure With Reduced Ejection Fraction, Hypotension
Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension
The evidence-based pharmacologic treatments available for patients with heart failure with reduced ejection fraction (HFrEF) has been established over the last few decades of cardiovascular research.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Hypotension, LV Dysfunction
- Trial name
- MIDOH-HF-P (NCT06405555)
- Testing
- Midodrine Oral Tablet
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Congestive Heart Failure
The Effect of Left Ventricular Filling Pressure on Pulmonary Clearance of Free Radical Loaded White Blood Cells and Platelets in Congestive Heart Failure Patients Before and After Biventricular Pacing
1. To assess whether a correlation exist between the degree of pulmonary clearance of free radical positive white bloodcells and platelets and the degree of pulmonary congestion in congestive heart failure (CHF) patients 2.
- Trial name
- OXIS-PACING (NCT00716885)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Cardiomyopathies, Congestive Heart Failure
Survey of QRS Frequency at Various Left Ventricular Pacing Sites for Cardiac Resynchronization
LV pacing at various sites with recording of ECG and subsequent signal analysis at different sites.
- Trial name
- NCT03253809
- Testing
- Biotronik Vision Guidewire
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The Cleveland Clinic
Heart Failure, Photoplethysmography
Seerlinq: Non-invasive LVFP Monitoring in HF
Left ventricular filling pressure (LVFP) monitoring has been associated with improved quality of life, survival and reduced hospitalization rates.
- Conditions
- Heart Failure, Photoplethysmography, Right Heart Catheterization
- Trial name
- PPG-HF (NCT06649435)
- Testing
- PPG measurement
- Where
- Slovakia
- Volunteers
- 131 people
- Sponsor
- Seerlinq s. r. o.
Left Ventricular Ejection Fraction, Heart Failure (HF)
REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)
Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide…
- Conditions
- Left Ventricular Ejection Fraction, Heart Failure (HF), Left Bundle-Branch Block
- Trial name
- REINVENT (NCT05652218)
- Testing
- LB-CRT, BIV-CRT
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Inova Health Care Services
End-stage Heart Failure, Left Ventricular Assist Device
LVAD Index and Clinical Outcomes in Continuous-Flow LVAD Patients
This single-center, observational study evaluated the LVAD index, defined as device-estimated pump flow divided by body surface area, in adult patients supported with continuous-flow left ventricular assist devices.
- Conditions
- End-stage Heart Failure, Left Ventricular Assist Device, Mechanical Circulatory Support
- Trial name
- LVAD-INDEX (NCT07633535)
- Testing
- HeartWare Ventricular Assist Device, HeartMate 3 Left Ventricular Assist Device
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Gaziantep City Hospital
Acute Heart Failure, COPD Exacerbation
Valsalva Manœuvre in the Diagnosis of Left Ventricular Failure in Chronic Obstructive Pulmonary Disease Exacerbation
Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis .
- Trial name
- NCT01619540
- Testing
- Valsalva maneuver
- Where
- 4 sites in Tunisia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Bleeding, Clot Blood
Aspirin and Hemocompatibility Events in Chronic Advanced Heart Failure Patients With Assist Device
Heart failure is a world epidemic. LVADs are increasingly used as they have demonstrated improved survival rates compared to optimal medical management.
- Trial name
- NCT06655376
- Testing
- Aspirin, Warfarin
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- Columbia University
Heart Failure, Left Ventricular Dysfunction
Pilot Study of Remote Ischemic Preconditioning in Heart Failure
The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.
- Trial name
- NCT01128790
- Testing
- Remote ischemic preconditioning
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Heart Failure
Sentus QP - Extended CRT Evaluation With Quadripolar Left Ventricular Leads
The QP ExCELs study is designed to confirm safety and efficacy of the BIOTRONIK Sentus OTW QP left ventricular leads to satisfy FDA requirements for regulatory approval of the leads in the US.
- Trial name
- QP ExCELs (NCT02290028)
- Testing
- Sentus QP left ventricular lead
- Where
- 119 sites in United States, Australia and 9 more
- Volunteers
- 2,226 people
- Sponsor
- Biotronik SE & Co. KG
Multi Organ Failure, Left Ventricular Dysfunction
Acute Cardiac Dysfunction in Critical Illnes
The overall aim of the study is to establish the clinical importance of cardiac dysfunction, by estimating its incidence and impact on short- and long-term outcomes, in a mixed population of critically ill patients with…
- Conditions
- Multi Organ Failure, Left Ventricular Dysfunction, Right Ventricular Dysfunction, Tako Tsubo Cardiomyopathy
- Trial name
- NCT05860504
- Testing
- Echocardiography, Cardiac magnetic resonance imaging, Coronary CT
- Where
- Sweden
- Volunteers
- 592 people
- Sponsor
- Sahlgrenska University Hospital
Heart Failure, Left Ventricular Dysfunction
PARACHUTE V PercutAneous Ventricular RestorAtion in Chronic Heart FailUre Due to Ischemic HearT DiseasE.
Prospective, multi-center, post-market, non-randomized, nested-control, observational study of the CE marked CardioKinetix Parachute Implant System.
- Trial name
- P5 (NCT02543632)
- Testing
- Parachute Implant System
- Where
- 10 sites in Germany
- Volunteers
- 85 people
- Sponsor
- CardioKinetix, Inc
Heart Failure
Outcomes of a Novel Magnetically Levitated LVAD: a Multicenter Analysis
This multicenter, retrospective cohort study evaluates the clinical outcomes associated with a novel fully magnetically levitated left ventricular assist device (LVAD) in patients with advanced heart failure.
- Trial name
- NCT06596499
- Testing
- CH-VAD
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing Anzhen Hospital
Refractory Heart Failure, Cardiovascular Diseases (CVD)
European Study of the BrioVAD Heart Pump for Advanced Heart Failure
This clinical investigation evaluates the safety and clinical performance of the BrioVAD Left Ventricular Assist System in patients with advanced, refractory left ventricular heart failure who require mechanical circulatory…
- Trial name
- BRIOLIFE (NCT07252531)
- Testing
- LVAD implantation
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- BrioHealth BV
Left-Sided Heart Failure, Right-Sided Heart Failure
Echocardiography as Risk-Assessment for Major Adverse Cardiac Events in Major Vascular Surgery Patients
Patient with coronary artery disease (CAD), heart failure and abnormal heart function undergoing major vascular surgery have a high associated high morbidity and mortality with myocardial infarction accounting for 33-50% of…
- Conditions
- Left-Sided Heart Failure, Right-Sided Heart Failure, Heart Valve Diseases
- Trial name
- NCT04836702
- Volunteers
- 813 people
- Sponsor
- University of Virginia