Clinical trials: Left Side
Systolic Left Ventricular Dysfunction
Performance and Safety of the Cardiac Microcurrent Therapy System
Patients with idiopathic dilative cardiomyopathy who have systolic left ventricular dysfunction (NYHA III - IV) despite adequate therapy according to treatment guidelines of heart failure and who have a baseline left ventricular…
- Trial name
- C-MIC-II (NCT04662034)
- Testing
- CMIC, Standard of Care (SOC)
- Where
- 20 sites in Bosnia and Herzegovina, Bulgaria and 9 more
- Volunteers
- 70 people
- Sponsor
- Berlin Heals GmbH
Hypertrophic Cardiomyopathy
Paced Dyssynchrony and Myocardial Perfusion IN apiCal Hcm
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease. A relatively common subgroup of HCM patients have apical HCM - a type of heart muscle disease that causes abnormal muscle thickening towards the tip…
- Trial name
- PINCHcm (NCT04231032)
- Testing
- Asynchronous dual chamber pacing (DOO) with paced ventricular activation, Asynchronous atrial pacing (AOO) with intrinsic ventricular activation
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Barts & The London NHS Trust
Colon Cancer
Colonic Resection or Stoma, or Self-expandable Metallic Stent for obstruCtive Left cOlon Cancer
CROSCO-1 study is a national, multi-center, prospective observational study presenting patients to the emergency departments of the participating centers with obstructive left colon cancer (in the absence of metastases and…
- Trial name
- CROSCO-1 (NCT05801211)
- Testing
- primary tumor resection
- Volunteers
- 434 people
- Sponsor
- Azienda Sanitaria di Firenze
Heart Failure, Atrial Fibrillation
Conduction System Pacing and AV Junction Ablation in Heart Failure With Atrial Fibrillation (SYNC AF-HTx)
The purpose of this study is to evaluate the safety and efficacy of conduction system pacing (CSP) using left bundle branch pacing (LBBP) and atrioventricular junction (AVJ) ablation in patients with end-stage heart failure and…
- Conditions
- Heart Failure, Atrial Fibrillation, Defibrillators, Implantable
- Trial name
- NCT07332871
- Testing
- LBBP + AVJ Ablation with ICD, ICD Only
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Post-Operative Atrial Fibrillation
AtriClip® Left Atrial Appendage Exclusion Concomitant to Structural Heart Procedures (ATLAS)
Patients without a documented history of Atrial Fibrillation (AF) and will undergo a valve or Coronary Artery Bypass Graft (CABG) procedure with direct visual access to the Left Atrial Appendage (LAA) will be eligible to…
- Trial name
- ATLAS (NCT02701062)
- Testing
- AtriClip® Gillinov-Cosgrove™ LAA Exclusion Systems, Anticoagulation Therapy
- Where
- 22 sites in United States
- Volunteers
- 562 people
- Sponsor
- AtriCure, Inc.
Complication of Treatment
SEMS Placement Followed by Chemotherapy and Surgery for Obstructing Left-sided Colonic Cancer
This study aimed to evaluate the safety and feasibility of SEMS followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer.
- Trial name
- NCT04039360
- Testing
- self-expanding metallic stent placement followed by neoadjuvant chemotherapy
- Volunteers
- 11 people
- Sponsor
- Beijing Chao Yang Hospital
Colorectal Cancer, Liver Metastasis
Surgical Recovery After Left Lateral Hepatic Sectionectomy: Laparoscopic Versus Open Surgery.
The ORANGE II trial is a double blinded randomised controlled trial that will provide evidence on the merits of laparoscopic surgery in patients undergoing a left lateral hepatic sectionectomy in terms of time to functional…
- Conditions
- Colorectal Cancer, Liver Metastasis, Liver Disease
- Trial name
- ORANGE II (NCT00874224)
- Testing
- laparoscopic left lateral hepatic sectionectomy, open left lateral hepatic sectionectomy
- Where
- Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Breast Cancer, Heart Failure
Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction
Trastuzumab is an important treatment for HER 2 positive breast cancer. But trastuzumab can cause injury to the heart, and this is one of the main reasons it cannot be administered as planned.
- Trial name
- SCHOLAR-2 (NCT04680442)
- Testing
- Trastuzumab, Pertuzumab, Trastuzumab emtansine
- Where
- 8 sites in Brazil, Canada and 1 more
- Volunteers
- 130 people
- Sponsor
- Population Health Research Institute
Arrhythmias, Cardiac, Atrioventricular Block
ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing
The goal of this observational study is to evaluate the clinical characteristics of patients undergoing permanent cardiac pacing and to compare procedural efficacy and safety of different implantation approaches in the clinical…
- Conditions
- Arrhythmias, Cardiac, Atrioventricular Block, Reduced Systolic Function, Atrial Fibrillation
- Trial name
- TREEBEARD (NCT06324682)
- Testing
- Cardiac pacing - Conventional RV pacing, Cardiac pacing - Conduction System Pacing, Cardiac pacing - Cardiac resynchronization therapy (pacing - CRTP - or defibrillation - CRTD)
- Where
- 31 sites in Italy
- Volunteers
- 8,400 people
- Sponsor
- University Hospital of Ferrara
Atrial Fibrillation
Retrospective Registry Providing Baseline Data on the Outcome of Left Atrial (LA) or LA Appendage (LAA) Thrombus in Patients With Nonvalvular Atrial Fibrillation (AF) or Atrial Flutter After Standard of Care (SoC) Anticoagulant Therapy
Thrombus outcome data will be collected retrospectively during 2011-2012 as a historical baseline of SoC with oral VKA (Vitamin K Antagonist(s) for the treatment of patients with nonvalvular AF or atrial flutter documented with…
- Trial name
- CLOT-AF (NCT01928979)
- Testing
- no drug
- Where
- 7 sites in Bulgaria, France and 5 more
- Volunteers
- 160 people
- Sponsor
- Bayer
Sickle Cell Disease
Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis
Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non invasive technique that may allow…
- Trial name
- NCT04864041
- Testing
- Evaluation of global longitudinal strain using routinely recorded echocardiography images
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Bicetre Hospital
ST Elevation (STEMI) Myocardial Infarction
LA Strain in Predicting Early Complication in STEMI After PPCI
The goal of this observational study To evaluate the predictive value of left atrial strain for in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing PPCI.
- Trial name
- NCT07263282
- Testing
- 2D echocardiography
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Assiut University
Airway Morbidity, Intubation Complication
Repositioning Method for Left-sided Double Lumen Tubes
The purpose of this study is to devise repositioning method of a left-sided double lumen tube into left mainstem bronchus in case of misplacement into right mainstem bronchus.
- Trial name
- NCT01371773
- Testing
- repositioning method for left-sided double lumen tubes
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Heart Failure
Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device (LVAD) and Medical Management
The purpose of this study is to evaluate and compare the effectiveness of the HeartMate II (HM II) Left Ventricular Assist Device (LVAD) support versus OMM in ambulatory NYHA Class IIIB/IV heart failure patients who are not…
- Trial name
- ROADMAP (NCT01452802)
- Testing
- HM II (HeartMate II LVAD), OMM (Optimal Medical Management)
- Where
- 52 sites in United States
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
Obesity, Weight Loss
Bariatric Embolization Trial for the Obese Nonsurgical
The purpose of this study is to assess the safety profile of bariatric embolizations and confirm published reports of sustained post-procedural weight loss, and pathologically assess post-procedural metabolic effects.
- Conditions
- Obesity, Weight Loss, Body Weight, Morbid Obesity
- Trial name
- BET-ON (NCT03601273)
- Testing
- Left gastric artery embolization
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Chronic Heart Failure, Iron Deficiency
Intravenous Iron Treatment in Patients With Heart Failure and Iron Deficiency: IRONMAN
This study will address whether the additional use of Intravenous (IV) iron on top of standard care will improve the outlook for patients with heart failure and iron deficiency.
- Conditions
- Chronic Heart Failure, Iron Deficiency, Left Ventricular Systolic Dysfunction
- Trial name
- IRONMAN (NCT02642562)
- Testing
- Ferric Derisomaltose
- Where
- 72 sites in United Kingdom
- Volunteers
- 1,160 people
- Sponsor
- University of Glasgow
Congenital Heart Disease, Hypoplastic Left Heart Syndrome
Genetic Determinants of Congenital Heart Disease Outcomes
The purpose of this study is to examine the role of genetic variation in the oxidative stress response on critical perioperative and short-term outcomes after neonatal heart surgery.
- Conditions
- Congenital Heart Disease, Hypoplastic Left Heart Syndrome, Hypoplastic Right Heart Syndrome, d-Transposition of the Great Arteries
- Trial name
- GECHO (NCT01656941)
- Where
- 5 sites in United States, Australia
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Hypoplastic Left Heart Syndrome (HLHS), Aortic Arch Hypoplasia
Seeking for Perfected Aortic Arch Reconstruction Using a Graphically Designed Patient-specific Surgical Patch
Vascular Reconstruction is one of the most challenging areas of surgery, the surgeon has to create a completely watertight reconstruction without any narrowing or deformity that will restore normal flow characteristics, even at…
- Trial name
- NCT06853054
- Testing
- Personalized patch template
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Colitis, Ulcerative
Trichuris Suis Ova Treatment in Left-sided Ulcerative Colitis
The purpose of this study is to evaluate the safety and effectiveness of trichuris suis ova (TSO) in ulcerative colitis (UC). We will look at how TSO affects the body's immune response and if there are related changes in…
- Trial name
- NCT01953354
- Testing
- Trichuris suis ova (TSO)
- Where
- 17 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Left Ventricular Dysfunction, Coronary Artery Bypass Surgery
Laboratory Outcome Predictors in Coronary Surgery
Evaluate less employed markers of tissue hypoperfusion as venoarterial carbon dioxide partial pressure difference (ΔPCO2) and estimated respiratory quotient (eRQ) combined to other classically studied markers as predictive…
- Conditions
- Left Ventricular Dysfunction, Coronary Artery Bypass Surgery, Tissue Hypoperfusion
- Trial name
- NCT01178866
- Where
- Brazil
- Volunteers
- 87 people
- Sponsor
- University of Sao Paulo
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