Clinical trials: Left Ventricle Function
Rheumatoid Arthritis, Coronary Artery Disease
Effects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery Disease
Inhibition of interleukin-1 (IL-1) activity in patients with RA without CAD ameliorates vascular and LV function. Moreover, data from species shows beneficial effect of this treatment on LV function after experimental myocardial…
- Conditions
- Rheumatoid Arthritis, Coronary Artery Disease, Inflammation
- Trial name
- NCT01566201
- Testing
- anakinra
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Athens
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Dilated Cardiomyopathy
Effect of Allopurinol on Left Ventricular Function in Children With Dilated Cardiomyopathy
The aim of this study is to detect effect of allopurinol supplementation in pediatric patients with dilated cardiomyopathy.
- Trial name
- NCT05193838
- Testing
- Allopurinol Tablet
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Preeclampsia
Left Ventricular and Endothelial Function in Preeclampsia
The purpose of this study is (1) to examine whether the left ventricular function is impaired in women with preeclampsia relative to healthy pregnant controls, (2) to examine whether the endothelial function is impaired in women…
- Trial name
- NCT00201500
- Where
- Norway
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Rheumatoid Arthritis, Inflammation
Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid Arthritis
Recent studies show beneficial effect of the inhibition of interleukin-6 (IL-6) activity on vascular and left ventricular (LV) function.
- Trial name
- NCT03288584
- Testing
- Tocilizumab (Actemra®), Other biological agent, Corticosteroid and non-biological agents.
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Obstructive Sleep Apnea
Structural and Functional Left Ventricular Remodelling in Patients With Obstructive Sleep Apnea
The purpose of this study is to determine whether patients with obstructive sleep apnea have any changes in left ventricular function and structure after 06 months of continuous positive airway pressure treatment.
- Trial name
- NCT00768807
- Testing
- CPAP (continuous positive airway pressure)
- Where
- Brazil
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Heart Failure With Preserved Ejection Fraction, Heart Failure With Midrange Ejection Fraction
Transcutaneous Vagus Nerve Stimulation in Heart Failure
Several studies have shown that alterations in autonomic nervous system function are implicated in the onset and progression of numerous cardiovascular diseases.
- Trial name
- TRANSFER (NCT05789147)
- Testing
- Active tVNS
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Chronic Kidney Disease, Hypertrophy, Left Ventricular
Effects of a Reduction in Renal Function on Cardiovascular Structure and Function
Chronic kidney disease (CKD) is present in 1 in 7 of the population and confers a high risk of cardiovascular disease. The pathophysiology of cardiovascular disease in CKD is poorly understood because CKD is always accompanied by…
- Conditions
- Chronic Kidney Disease, Hypertrophy, Left Ventricular, Hypertension
- Trial name
- CRIB-DONOR II (NCT02973607)
- Testing
- Nephrectomy
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Acromegaly
Cardiac (CMRI) Assessment of Acromegaly
In this study, the investigators will evaluate the cardiac structure and function, focusing on the myocardial water content and interstitial fibrosis, in patients with active acromegaly in comparison with 1) healthy volunteers…
- Trial name
- ACROCOEUR (NCT02948322)
- Testing
- CMRI, Gadolinium, OGTT
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Irbesartan and Atenolol in Hypertensive Heart Disease
The renin-angiotensin-aldosterone system has been implicated in the control of structural changes of the heart and the vasculature, beyond the effects on blood pressure.
- Trial name
- SILVHIA (NCT00389168)
- Testing
- Irbesartan, Atenolol
- Where
- Sweden
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hypertension,Essential
Endothelial Function in Prehypertension
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and…
- Trial name
- NCT06316271
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Left Ventricular Function, Arrhythmia
Impact of Radiofrequency Ablation on Left Ventricular Function in Supraventricular Tachyarrhythmias Patient Using Speckle Tracking Echocardiography
In this study, we aimed to evaluate atrial and ventricular function in supraventricular tachyarrhythmia patients before and 3 months after RFA using 2DSTE.
- Trial name
- NCT05225662
- Testing
- radiofrequency ablation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Failure
Non-invasive Pressure-Volume Analysis (NIPVA)
If the heart fails to pump a sufficient amount of blood, it is crucial to know why in order to provide the best treatment. Pressure-volume analysis is the gold standard for evaluating the heart's pumping function.
- Trial name
- NIPVA (NCT01960894)
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Acute Myocardial Infarction
Strain-Encoded Magnetic Resonance Imaging in Acute Myocardial Infarction
The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to transmurality states of infarcted tissue in…
- Trial name
- 137-2005 (NCT00752713)
- Testing
- cardiac MRI
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Valvular Heart Disease
Effect of Desflurane on Cardiac Function During Cardiac Surgery: Tissue Doppler Imaging of Mitral Valve Annular Velocity
The purpose of this study is to determine desflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery.
- Trial name
- NCT02003885
- Testing
- increment of desflurane
- Where
- South Korea
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Type 2 Diabetes Mellitus
Effect of Pioglitazone on Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus
This study is being done to determine if pioglitazone (Actos) is helpful to patients with type 2 diabetes and could possibly prevent harmful consequences of cardiovascular disease in diabetic patients.
- Trial name
- NCT00232362
- Testing
- Pioglitazone (Actos), Anti-diabetic agent other than pioglitazone or rosiglitazone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Coronary Endothelial Dysfunction, Apical Ballooning Syndrome
The Relationship Between the Response to Mental Stress and Vascular Endothelial Function
The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects.
- Conditions
- Coronary Endothelial Dysfunction, Apical Ballooning Syndrome, Myocardial Infarction
- Trial name
- NCT00975559
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Aortic Stenosis, Cardiac Death
Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression and Severity
There is a correlation between endothelial progenitor cells (stem cells) and stenosis of the aortic valve.
- Trial name
- NCT02060071
- Testing
- Blood test
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
OSA, Left Ventricular Dysfunction
Evaluation of Left Ventricular Function and Therapeutic Effect of CPAP in Patients With OSAS by 3D STE
The changes of left ventricular function in patients with sleep apnea were studied by three-dimensional speckle-tracking echocardiography to evaluate the changes of left ventricular function after CPAP treatment
- Trial name
- NCT04957004
- Testing
- CPAP
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Healthy
Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart.
- Trial name
- NCT00001528
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)