Clinical trials: Left Ventricular Cardiac Dysfunction
Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Heart scarring, also known as fibrosis, plays a major role in a lot of heart muscle abnormalities. These abnormalities of the heart muscle can lead to major issues such as symptoms of heart failure, dangerous heart rhythm…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy, Cardiac Sarcoidosis, Hypertensive Heart Disease
- Trial name
- CHIEFTain (NCT06409585)
- Testing
- 68Ga-FAPI or 18F-AlF-FAPI cardiac PET-MR, Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Chronic Kidney Diseases, Left Ventricular Systolic Dysfunction
Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal Ultrasonography
The goal of this observational study is to learn about the value of multimodal ultrasound in early detection of left ventricular systolic dysfunction in patients with chronic kidney disease(CKD).
- Trial name
- NCT06221891
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
RV - Right Ventricular Abnormality, LV Dysfunction
Pediatric Ventricle Function Assessment Study
This study aims to develop a deep learning-based framework for right ventricular (RV) segmentation, prediction of RV fractional area change (FAC), and identification of pediatric RV dysfunction.
- Conditions
- RV - Right Ventricular Abnormality, LV Dysfunction, Pulmonary Hypertension, TOF
- Trial name
- NCT06739057
- Where
- United States
- Volunteers
- 3,993 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Left Ventricular (LV) Systolic Dysfunction
AI-Enabled Electrocardiogram-Guided Guideline-Directed Medical Therapy on Incident Left Ventricular Dysfunction: A Target Trial Emulation Study
This multicenter retrospective study evaluates whether artificial intelligence-enabled electrocardiography (AI-ECG) can identify individuals at high risk for left ventricular dysfunction and whether targeted guideline-directed…
- Trial name
- NCT07355023
- Testing
- Guideline-directed medical therapies
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Heart Failure, Ventricular Dysfunction, Left
ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment Era
Asymptomatic left ventricular systolic dysfunction (ALVSD), identified as a key component of stage B heart failure (HF) by AHA/ACC guidelines, is a common precursor to clinically overt HF.
- Conditions
- Heart Failure, Ventricular Dysfunction, Left, Artificial Intelligence, Early Diagnosis
- Trial name
- ELEGANT (NCT06968533)
- Testing
- AI-ECG guided diagnosis
- Where
- Taiwan
- Volunteers
- 13,350 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain
The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).
- Conditions
- Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Global Cardiac Wall Motion Dysfunction
- Trial name
- NCT05650008
- Testing
- Intrathecal local anesthesia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tako-tsubo Cardiomyopathy
Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation?
Tako Tsubo Cardiomyopathy (TTC), also known as "Broken Heart Syndrome", is a disorder of the heart that occurs most commonly in women (although it occasionally occurs in men) and is usually related to a stressful event.
- Trial name
- TERRIFIC (NCT02897739)
- Testing
- Magnetic resonance imaging, Acute Inflammatory Activation study, PET CT
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Left Ventricular Dysfunction, Ventricular Dysfunction
Low Ejection Fraction in Single Lead ECG
The purpose of this research is to prospectively test and validate the single-lead Low EF algorithm in outpatients in order to test the performance of a single-lead ECG based algorithm to identify people with decreased left…
- Conditions
- Left Ventricular Dysfunction, Ventricular Dysfunction, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT05010655
- Testing
- Use of Eko DUO Electronic Stethoscope
- Where
- 2 sites in United States
- Volunteers
- 1,935 people, healthy volunteers welcome
- Sponsor
- Eko Devices, Inc.
Acromegaly
Cardiac (CMRI) Assessment of Acromegaly
In this study, the investigators will evaluate the cardiac structure and function, focusing on the myocardial water content and interstitial fibrosis, in patients with active acromegaly in comparison with 1) healthy volunteers…
- Trial name
- ACROCOEUR (NCT02948322)
- Testing
- CMRI, Gadolinium, OGTT
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Takotsubo Cardiomyopathy
The Role of Emotional Stress in Patients With Stress-induced Cardiomyopathy
The event-related potentials may be different in patients with Takotsubo cardiomyopathy than in patients without Takotsubo.
- Trial name
- NCT02361073
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Magdeburg
Premature Ventricular Beats, Premature Ventricular Complexes
Flecainide in Idiopathic Premature Ventricular Contractions and Related Cardiomyopathy
The UNIFLECA study is a prospective, single-arm, observational cohort evaluating the efficacy, safety, and tolerability of flecainide (in the form of Sanocard) in adults with frequent idiopathic premature ventricular contractions…
- Conditions
- Premature Ventricular Beats, Premature Ventricular Complexes, Premature Ventricular Contraction (PVC), Arrhythmia Ventricular
- Trial name
- UNIFLECA (NCT06949748)
- Testing
- Flecainide (monotherapy)
- Where
- 6 sites in Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Athens
Heart Failure
Identification Of Blood Markers For Asymptomatic Ventricular Dysfunction
The diagnosis of asymptomatic left ventricular dysfunction is difficult in general practice since it requires transthoracic cardiac echocardiography that is generally performed in specialized services.
- Trial name
- IBLOMAVED (NCT01024049)
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
STEMI - ST Elevation Myocardial Infarction, Left Ventricular Systolic Dysfunction
The Effect of Early Administration of Dapagliflozin in STEMI Patients With LV Systolic Dysfunction
300 STIMI patients with LV systolic dysfunction will be divided into two equal groups (Group I (Study arm, n=150); will receive dapagliflozin plus conventional therapy and group (II) Control arm (n=150); will receive conventional…
- Trial name
- NCT05045274
- Testing
- Dapagliflozin 10Mg Tab
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypertrophic Cardiomyopathy, Endothelial Dysfunction
Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies
Left ventricular obstruction is an invalidating complication of hypertrophic cardiomyopathies (HCM), and endothelial dysfunction has also been observed in these pathologies.
- Trial name
- HCM-Vein (NCT04129905)
- Testing
- BNP blood sample test, Electrocardiogram, Holter ECG
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Myocardial Ischemia, Left Ventricular Systolic Dysfunction
The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging
Using blood testing and cardiac magnetic resonance imaging (MRI), the investigators aim to determine if there are necrotic areas of myocardium in participants who complete a marathon.
- Conditions
- Myocardial Ischemia, Left Ventricular Systolic Dysfunction, Elevated Cardiac Enzymes
- Trial name
- MARATHON-MRI (NCT00752752)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Heart Diseases, Left Ventricular Dysfunction
Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction
To test the specific research questions, healthy men and age-matched healthy premenopausal females will be enrolled. Subjects will undergo cardiac magnetic resonance imaging and spectroscopy (MRI/MRS) to evaluate cardiac…
- Trial name
- NCT04671966
- Testing
- Estradiol patch, Cetrotide, Fasting
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington