Clinical trials: Left Ventricular Dysfunction
Hypertrophic Cardiomyopathy, Endothelial Dysfunction
Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies
Left ventricular obstruction is an invalidating complication of hypertrophic cardiomyopathies (HCM), and endothelial dysfunction has also been observed in these pathologies.
- Trial name
- HCM-Vein (NCT04129905)
- Testing
- BNP blood sample test, Electrocardiogram, Holter ECG
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Heart Failure, Heart Failure With Reduced Ejection Fraction
AI-ECG for Time-Resolved Prediction of HFrEF
This study aims to develop and validate a deep learning-based electrocardiogram (ECG) model for predicting the future risk of heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricular Dysfunction, Cardiac Remodeling
- Trial name
- NCT07519434
- Where
- China
- Volunteers
- 286,709 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Sleep Apnea, Ventricular Arrythmias
Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias
Hypothesis: The CPAP treatment diminishes the effect of ventricular arrhythmias in patients with ischemic heart disease or dilated myocardiopathy, systolic ventricular disfunction and sleep apnea-hypopnea syndrome…
- Conditions
- Sleep Apnea, Ventricular Arrythmias, Systolic Left Ventricle Dysfunction
- Trial name
- SAHS-ICD (NCT00765713)
- Testing
- Nasal continuous positive airway pressure
- Where
- 3 sites in Spain
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
Cardiovascular Diseases
The STandard Versus ImAging SuBstrate Aided Ablation in Severe Left VEntricular Dysfunction VT.
The STABLE-VT trial aims to determine the safety profile and clinical efficacy of a modified approach to ventricular tachycardia (VT) ablation that integrates myocardial scar as visualized on cardiac magnetic resonance (c-MRI) or…
- Trial name
- STABLE-VT (NCT05828667)
- Testing
- Incorporation of CT and/or c-MRI derived myocardial scar with 3D electroanatomical mapping (EAM).
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
OSA, Left Ventricular Dysfunction
Evaluation of Left Ventricular Function and Therapeutic Effect of CPAP in Patients With OSAS by 3D STE
The changes of left ventricular function in patients with sleep apnea were studied by three-dimensional speckle-tracking echocardiography to evaluate the changes of left ventricular function after CPAP treatment
- Trial name
- NCT04957004
- Testing
- CPAP
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Takotsubo Cardiomyopathy
Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy
The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome.
- Trial name
- TAKO MEMRI (NCT07491718)
- Testing
- Bisoprolol, Valsartan, sacubitril/ valsartan
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Left Ventricular Diastoic Dysfunction Cohort Study
Epidemic Profile of Left Ventricular Diastoic Dysfunction in the Community Elderly and Establishing Prediction Model: the Northern Shanghai Study
This study is one of the largest ongoing prospective population studies to evaluate target organ damages (TODs) and Left Ventricular Diastoic Dysfunction in the community-dwelling elderly Chinese, which is authorised and funded…
- Trial name
- ELITISM (NCT03735251)
- Testing
- Diuretic，Betaloc，antiplatelet drugs
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- Ya-Wei Xu
Embolic Stroke of Undetermined Source, Endothelial Dysfunction
Impaired Endothelial Integrity in Patients With Embolic Stroke of Undetermined Source (ESUS)
The investigators will measure endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left ventricular (LV) and left atrial (LA) function in ESUS, cardioembolic, atherosclerotic, lacunar…
- Trial name
- ESUS (NCT03609437)
- Where
- Greece
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Athens
Kidney Disease, Left Ventricular Hypertrophy
Do Xanthine Oxidase Inhibitors Reduce Both Left Ventricular Hypertrophy and Endothelial Dysfunction in Cardiovascular Patients With Renal Dysfunction?
Cardiovascular related disease is the main cause of death in patients with kidney disease, and "oxidative stress" is thought to be a major contributor by promoting thickening of the heart muscle and stiffening of the arteries.
- Trial name
- NCT00688480
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- A. D. Struthers
Chronic Kidney Disease
Effects of a Reduction in Kidney Function on Cardiovascular Structure and Function: A Prospective Study of Kidney Donors
Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death.
- Trial name
- NCT01028703
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Fibromyalgia (FM), Subclinical Ventricular Dysfunction
Evaluation of Myocardial Function by Global Longitudinal Strain (GLS) Measurement in 2D Echocardiography of Patients With Fibromyalgia
Fibromyalgia (FM) is a chronic pain syndrome that affects multiple body systems and is often associated with fatigue, sleep disturbances, anxiety, and other comorbidities.
- Conditions
- Fibromyalgia (FM), Subclinical Ventricular Dysfunction, Myocardial Function
- Trial name
- GLS in FM (NCT07150455)
- Testing
- Echocardiographic Assessment (2D Speckle Tracking)
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
RV - Right Ventricular Abnormality, LV Dysfunction
Pediatric Ventricle Function Assessment Study
This study aims to develop a deep learning-based framework for right ventricular (RV) segmentation, prediction of RV fractional area change (FAC), and identification of pediatric RV dysfunction.
- Conditions
- RV - Right Ventricular Abnormality, LV Dysfunction, Pulmonary Hypertension, TOF
- Trial name
- NCT06739057
- Where
- United States
- Volunteers
- 3,993 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Cardiomyopathy
Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy
Stress (Takotsubo) cardiomyopathy (SC) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments.
- Trial name
- NCT01048125
- Testing
- Sympathetic Nerve Activity, Mental Stress Test (Color Word Test), The Modified Oxford Technique for Baroreflex Sensitivity
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Takotsubo Cardiomyopathy
The Role of Emotional Stress in Patients With Stress-induced Cardiomyopathy
The event-related potentials may be different in patients with Takotsubo cardiomyopathy than in patients without Takotsubo.
- Trial name
- NCT02361073
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Magdeburg
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Acute Kidney Injury (Nontraumatic)
Comparison Between Right and Left Ventricular Systolic Dysfunction as a Risk Factors for Aki in Critical Care Patients
The cardio renal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently.
- Trial name
- NCT03369561
- Testing
- Serum urea and creatinine and the calculated e GFR
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Takotsubo Cardiomyopathy
Life-style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy
Takotsubo cardiomyopathy presents like a heart attack and is typically triggered by intense emotional or physical stress. Recovery of this condition varies and many patients continue to suffer from symptoms such as fatigue and…
- Trial name
- BREAKOUT (NCT05530135)
- Testing
- Exercise program, Cognitive behavioural therapy, Standard clinical care
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Left Ventricular Dysfunction, Ventricular Dysfunction
Low Ejection Fraction in Single Lead ECG- Ochsner
The purpose of this research is to prospectively test and validate the single-lead Low EF algorithm in outpatients in order to test the performance of a single-lead ECG based algorithm to identify people with decreased left…
- Conditions
- Left Ventricular Dysfunction, Ventricular Dysfunction, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT05010642
- Testing
- Use of Eko DUO electronic Stethoscope
- Where
- United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Eko Devices, Inc.
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Heart Failure, Left Ventricular (LV) Systolic Dysfunction
AI-based Prediction of Cardiac Function Using Echocardiography and Body Composition Data (ECHO-FIT Study)
This prospective observational study (ECHO-FIT Study) aims to develop and validate a predictive model for cardiac function, particularly left ventricular ejection fraction (LVEF), by integrating echocardiographic measurements…
- Conditions
- Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Body Composition Measurement, Artificial Intelligence (AI)
- Trial name
- ECHO-FIT (NCT06811519)
- Testing
- Body Composition Analyzer (ACCUNIQ BC720)
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yonsei University