Clinical trials: Left Ventricular Ejection Fraction
Physical Activity, Heart Failure
WHISH-2-Prevent Heart Failure
The WHISH-2-Prevent Heart Failure (HF) study is an ancillary study to the Women's Health Initiative Strong and Healthy (WHISH) exercise pragmatic trial.
- Conditions
- Physical Activity, Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Normal Ejection Fraction
- Trial name
- NCT03099889
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 49,936 people, healthy volunteers welcome
- Sponsor
- Memorial Hospital of Rhode Island
Gallbladder
A Parallel Study Evaluating the Effect of A-F Betafood® on Gallbladder and Liver Function.
Gallstone formation is multifactorial: immutable risk factors include genetics and ethnicity, age and being female, and mutable risk factors include obesity, and metabolic syndrome, diet, rapid weight loss, and other conditions…
- Trial name
- NCT01981343
- Testing
- A-F Betafood
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Heart Failure With Reduced Ejection Fraction (HFrEF)
The Effectiveness of Collaborative Health Management Model on Heart Failure Patient
The purpose of this study is to explore the effect of the collaborative health management model on the functional status, quality of life and rehospitalization rate of patients with heart failure. This is a three-year project.
- Trial name
- NCT04860596
- Testing
- collaborative health management model
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Antai Medical Care Corperation Antai Tian-Sheng Memorial Hospital/ Department of Nursing/National Ta
Heart Failure, Congestive
Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a
Heart failure with preserved ejection fraction or HFpEF, represents nearly 50% of all heart failure cases and is particularly common in the elderly. The disease has no current treatment options.
- Trial name
- NCT02772068
- Testing
- Istaroxime, Exercise
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Benjamin Levine
Heart Failure, Sarcopenia
The Sarcopenia Study
The goal of this cross-sectional study is to investigate the prevalence of sarcopenia in patients with Heart Failure. The main question it aims to answer is: Whether there is a difference in the prevalence of sarcopenia across…
- Conditions
- Heart Failure, Sarcopenia, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05888688
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Heart Failure, Diastolic, Multicenter Study
Diagnosis and OutcoMes evaluAtIoN of Multicenter Patients With HFpEF Using Multimodality Imaging
The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are…
- Trial name
- NCT04602338
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure
Home-based Outpatient Multicenter Evaluation Using Electrocardiogram (HOME-ECG)
This prospective multicenter observational study will validate the accuracy of a previously developed artificial intelligence-enabled single-lead electrocardiogram (AI-ECG) model for identifying low ejection fraction and other…
- Trial name
- HOME-ECG (NCT07488052)
- Testing
- Single-Lead ECG Acquisition [Apple Watch and QOCA ECG102D]
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Breast Neoplasms
Evaluation of Myocardial Changes During BReast Adenocarcinoma Therapy to Detect Cardiotoxicity Earlier With MRI
Breast cancer is the most common cancer amongst Canadian women. 15-20% of early breast cancers have high levels of a protein called HER2 which is associated with worse survival.
- Trial name
- EMBRACE-MRI (NCT02306538)
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Heart Failure, Heart Failure With Preserved Ejection Fraction
Frequency and Magnitude of Subclinical Systolic Dysfunction by Strain Imaging in Heart Failure With Preserved Ejection Fraction
Background: Originally thought to be purely due to LV diastolic dysfunction, studies in western countries have suggested that heart failure with preserved ejection fraction (HFpEF) is more complex.
- Trial name
- NCT04163861
- Testing
- 2d speckle tracking echocardiography, serum BNP level
- Where
- Bangladesh
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Heart Failure With Normal Ejection Fraction
Validation of CMR Against Invasive Haemodynamics in Patients With HFpEF
Heart failure (HF) currently affects app. 2% of the western population and app. 10% of people >75 years. In about 50% of patients with symptomatic HF ejection fraction (EF) is preserved (HF-PEF).
- Trial name
- DECIPHER-HFpEF (NCT03251183)
- Testing
- Comprehensive Cardiovascular magnetic resonance (CMR), Blood sampling, TTE (EchoErgo)
- Where
- 7 sites in Germany
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Goethe University
Chest Pain, Shortness of Breath
Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction
The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart…
- Trial name
- NCT06927973
- Testing
- Echocardiogram
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may…
- Conditions
- Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Heart Failure, Right Sided, Heart Failure With Mid Range Ejection Fraction
- Trial name
- PREFER-HF (NCT03480633)
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Failure Preserved Ejection Fraction, Pacing
Mechanistic Insights From Temporary Pacing in HFpEF
Heart failure with preserved ejection fraction (HFpEF) is characterised by impaired diastolic function. A recent clinical trial has demonstrated multiple beneficial outcomes in HFpEF patients receiving personalised accelerated…
- Trial name
- NCT06467266
- Testing
- Acute Haemodynamic Study
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Hypertension; Heart Disease, Hypertensive
Effect of Aterial Stiffness on Myocardial Work in Patients With Hypertension
Hypertension is a serious threat to human health and a major global economic burden.Chronic hypertension can cause left ventricular remodeling and loss of function, eventually leading to heart failure.Exploring the early changes…
- Trial name
- NCT04573257
- Testing
- Echocardiography and pulse wave velocity measurement
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD
The aim of the study is to evaluate the influence of physical training and respiratory rehabilitation performed by patients at home on quality of life, symptoms, physical endurance, force of respiratory and skeletal muscles and…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Ischemic Heart Disease
- Trial name
- NCT03780803
- Testing
- home cardiac rehabilitation and respiratory rehabilitation
- Where
- Poland
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Heart Failure With Normal Ejection Fraction
Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of the heart failure population in the United States.
- Trial name
- NCT03465072
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure With Preserved Ejection Fraction, Hypomagnesemia
Intracellular Magnesium and Heart Failure
Low magnesium levels are surprisingly common in those with a heart condition known as HFpEF, where the heart pumps well but is too rigid to fill properly with blood.
- Trial name
- NCT06353750
- Testing
- Magnesium supplement
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Heart Failure
Improving Goal Directed Medical Therapy for Device Clinic Patients With Reduced EF at UOHI: a QI Initiative (VIGILANT)
This is a quality improvement initiative with the goal of optimizing heart failure (HF) patients seen through the outpatient cardiac implantable electronic device clinic at the University of Ottawa Heart Institute (UOHI).
- Trial name
- VIGILANT (NCT05085249)
- Where
- Canada
- Volunteers
- 2,479 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes
Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a condition in which the heart cannot fill with blood effectively. As a result, people with HFpEF suffer fatigue, breathlessness, and develop swollen limbs.
- Trial name
- MEMRI in HFpEF (NCT06652763)
- Testing
- Minnesota Living with Heart Failure Questionnaire, Echocardiogram, Six-minute walk test
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Hart Failure With Reduced Ejection Fraction
Magnesphere for Autonomic Alteration
To evaluate the physiologic effects of an electromagnetic resonator(EMF) on autonomic nervous system tone modulation through measurement of heart rate variability(HRV).
- Trial name
- NCT04207476
- Testing
- EMF
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma