Clinical trials: Left Ventricular Ejection Fraction, open to volunteers
Heart Failure With Preserved Ejection Fraction
Clinical Study of Active Intervention in High-risk HFpEF Patients
Based on inclusion and exclusion criteria, this experiment plans to include 924 Heart Failure with Preserved Ejection Fraction(HFpEF) patients with increased risk of all-cause death.
- Trial name
- NCT06532019
- Testing
- Targeted intervention based on risk factors
- Volunteers
- 924 people
- Sponsor
- Xiangtan Central Hospital
Heart Failure With Preserved Ejection Fraction, Chronic Pulmonary Thromboembolism (Disorder)
The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
To evaluate the role of exercise hemodynamic testing in the diagnostic workup for patients with dyspnea on exertion referred to the catheterization lab.
- Trial name
- EX_CATH (NCT05490901)
- Testing
- Exercise hemodynamic test
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Tricuspid Insufficiency, Tricuspid Regurgitation (TR)
PASCAL Precision-GDMT Registry
The goal of this observational study is to demonstrate that successful tricuspid valve repair with the PASCAL Precision System in participants with at least severe tricuspid insufficiency and left ventricular dysfunction will be…
- Conditions
- Tricuspid Insufficiency, Tricuspid Regurgitation (TR), Left Ventricular Cardiac Dysfunction, Left Ventricular (LV) Systolic Dysfunction
- Trial name
- PASCAL (NCT07578129)
- Volunteers
- 50 people
- Sponsor
- Ceric Sàrl
Heart Failure With Reduced Ejection Fraction, HFrEF - Heart Failure With Reduced Ejection Fraction
Intermediate Outcomes of HFrEF Patients on Guideline-Directed Medical Therapy
This prospective observational study aims to evaluate intermediate clinical, renal, and functional outcomes in patients with heart failure with reduced ejection fraction treated with contemporary guideline-directed medical…
- Trial name
- NCT07845201
- Volunteers
- 250 people
- Sponsor
- Assiut University
Heart Failure Preserved Ejection Fraction
Coronary Sinus Reducer For The Management Of Symptomatic Heart Failure
The purpose of this study is to evaluate the efficacy of CS Reducer implantation in patients with HFpEF and CMD on left ventricular filling pressures, specifically invasive measurement of PAWP during standardized exercise.
- Trial name
- NCT07057323
- Testing
- Coronary Sinus Reducer
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Heart Failure, Preserved Ejection Fraction, Cardiac Fibrosis
Characterization of Heart Failure With Preserved Ejection Fraction
The goals of this research will be to define some of the mechanisms underlying the progression and complications of heart failure (HF) with preserved left ventricular ejection fraction (HFPEF) Aim 1: to evaluate the differences…
- Conditions
- Heart Failure, Preserved Ejection Fraction, Cardiac Fibrosis, Biomarkers, Magnetic Resonance Imaging
- Trial name
- NCT03197350
- Testing
- cMR, biomarker
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Acute Myocarditis
MYTHS-MR Trial (MYocarditis THerapy With Steroids in Patients With Mildly Reduced Ejection Fraction)
The goal of this clinical trial is to demonstrate the efficacy of pulsed intravenous methylprednisolone in a single-blind randomized controlled trial versus standard therapy in patients with acute myocarditis and a mildly reduced…
- Trial name
- MYTHS-MR (NCT05974462)
- Testing
- Methylprednisolone 125 MG, IV saline solution 0.9%
- Where
- 19 sites in Belgium, Italy and 2 more
- Volunteers
- 174 people
- Sponsor
- University Hospital, Antwerp
Chronic Heart Failure, Cardiovascular Diseases
AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices
The goal of this observational, multicenter study is to evaluate whether AI-driven remote monitoring using a mini-invasive wearable device can improve clinical outcomes in adult patients (≥18 years) with chronic heart failure…
- Conditions
- Chronic Heart Failure, Cardiovascular Diseases, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- SMART-CARE (NCT06909682)
- Testing
- Intervention Group (Device Group - AI-Based Remote Monitoring), Standard Clinical Follow-Up
- Where
- Italy
- Volunteers
- 205 people
- Sponsor
- University of Salerno
Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCI
STRATUS-PCI is a pilot clinical trial that compares two ways of running a small heart pump called Impella CP during a high-risk procedure to open blocked heart arteries (percutaneous coronary intervention, or PCI) in patients…
- Trial name
- STRATUS-PCI (NCT07588399)
- Testing
- Impella CP
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Rayyan Hemetsberger
Heart Failure, Preserved Ejection Fraction
Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF
HFpEF has a high incidence and lacks effective therapy, and its onset is closely related to systemic inflammation and intestinal dysbacteriosis.SGLT-2i exerts its effects by diuresis, anti-inflammatory and improving energy…
- Trial name
- NCT07687212
- Testing
- Henggliflozin Combined with Probiotics, Henggliflozin
- Where
- China
- Volunteers
- 162 people
- Sponsor
- The First Affiliated Hospital of Air Force Medical University
Heart Failure and Reduced Ejection Fraction, Functional Mitral Regurgitation
Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance
This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodeling and clinical outcomes post TEER.
- Trial name
- SMARTER-CMR (NCT07131631)
- Testing
- Cardiac MRI
- Where
- 6 sites in United States, Italy
- Volunteers
- 125 people
- Sponsor
- Minneapolis Heart Institute Foundation
Heart Failure
Virtual Human Twins as Tools for Personalized Clinical Care in Heart Failure With Preserved Ejection Fraction: a Pilot Study
Heart failure (HF) is a heterogeneous clinical syndrome characterized by substantial inter-individual variability in pathophysiology and response to treatment.
- Trial name
- VITAL-HF (NCT07902453)
- Testing
- Data collection for the development and validation of the cardiovascular virtual human twin
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure With Reduced Ejection Fraction (HFrEF)
Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy.
- Trial name
- ECHO-LBBp (NCT06689111)
- Testing
- Left bundle branch pacing lead, CRT with the standard method through cs
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital of Patras
Heart Failure With Preserved Ejection Fraction
Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
- Trial name
- HFpEF-BB (NCT05174351)
- Testing
- beta blocker discontinuation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- UConn Health
Heart Failure With Preserved Ejection Fraction
Myocardial Stiffness Evaluation in Patients With Heart Failure With Preserved Ejection Fraction
The goal of this observational study is to evaluating myocardial stiffness in patients with heart failure with preserved ejection fraction (HFpEF) by intrinsic wave velocity propagation (IVP).
- Trial name
- NCT06196086
- Testing
- Echocardiography examination
- Where
- China
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Haiyan Wang
Heart Failure With Reduced Ejection Fraction, Cardiogenic Shock
Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF
This study aims to compare the impact of hemodynamic monitoring using pulmonary artery catheter (PAC) on survival and inotropic agent reduction in patients with cardiogenic shock caused by heart failure with reduced ejection…
- Trial name
- PACE-SHOCK (NCT06078436)
- Testing
- Pulmonary artery catheter
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Min-Seok Kim
HFpEF - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation
AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF).
- Trial name
- AlEX-DHF (NCT06650995)
- Testing
- Exercise training
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Microvascular Coronary Dysfunction, Cardiovascular Disease
WISE CVD - Continuation (WISE HFpEF)
The Women's Ischemia Study Evaluation (WISE), a cohort study of over 1000 women, has made many contributions to the understanding of cardiovascular disease.
- Trial name
- NCT02582021
- Testing
- Coronary Angiography, Coronary Reactivity Testing, Cardiac Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Cedars-Sinai Medical Center
Heart Failure, Heart Failure With Preserved Ejection Fraction
Assessment of CCM in HF With Higher Ejection Fraction
The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.
- Conditions
- Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction
- Trial name
- AIM HIGHer (NCT05064709)
- Testing
- Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, OPTIMIZER™ Smart Mini System
- Where
- 67 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Impulse Dynamics
Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction (HFPEF)
AI-based Echocardiography for Detection of Cardiac Amyloidosis
Cardiac amyloidosis is characterized by deposition of misfolded protein in the myocardium causing mainly heart failure symptoms with preserved left ventricular ejection fraction.
- Conditions
- Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction (HFPEF), Left Ventricular Hypertrophy
- Trial name
- ORCHESTRA (NCT07529860)
- Testing
- AI-based echocardiogram
- Volunteers
- 200 people
- Sponsor
- Germans Trias i Pujol Hospital