Clinical trials: Left Ventricular Function Diastolic Dysfunction
Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction
Cell Therapy in Diabetic Patients With ST-Segment Elevation Myocardial Infarction(STEMI)
The purpose of this study is to investigate the efficacy and mechanism of bone marrow mononuclear cells (BMMNC) transplantation for diabetic and non-diabetic patients with ST-segment elevation myocardial infarction (STEMI)who…
- Conditions
- Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction, Death, Myocardial Reperfusion Injury
- Trial name
- NCT01307371
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Xijing Hospital
HFpEF, LVDD
Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF
Patients with advanced heart failure with preserved ejection fraction (HFpEF) will be randomly assigned in open-label multicenter study to receive triple combination therapy with [angiotensin receptor/neprilysin inhibitor [ARNI]…
- Conditions
- HFpEF, LVDD, Myocardial Fibrosis
- Trial name
- NCT06655480
- Testing
- [ARNI + SGLTi + AMR], [SGLTi + previously taken RAAS blocker]
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Left Ventricular Dysfunction
Cardiac Function and Microcirculation: Type 2 DIABetes and ECHOcardiographic Changes Over Time
The purpose of this study was to investigate the influence of micro- and macrovascular changes on the cardiac function in relation to left ventricular function and coronary arteries during one year in patients with type 2…
- Trial name
- DIABECHO (NCT02956577)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Svendborg Hospital
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
Heart Failure, Left Ventricular Dysfunction
Effects of Viagra on Heart Function in Patients With Heart Failure
Sildenafil (Viagra) is known to reduce pulmonary hypertension. Heart failure patients also have pulmonary hypertension and several recent reports have shown that sildenafil leads to an improvement in their exercise capacity.
- Trial name
- NCT00781508
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- MetroHealth Medical Center
Hyperuricemia, Metabolic Syndrome
Hyperuricemia and Left Ventricular Diastolic Function
Metabolic syndrome and hyperuricemia were both associated with inflammation, leading to diversities of cardiovascular disease such as left ventricular diastolic dysfunction, but the relationship among these entities remained…
- Conditions
- Hyperuricemia, Metabolic Syndrome, Left Ventricular Diastolic Dysfunction
- Trial name
- NCT03495999
- Testing
- hyperuricemia
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- National Defense Medical Center, Taiwan
Left Ventricular Function Diastolic Dysfunction, Fluid Responsiveness
Evaluation of the E/e' Ratio of the Mitral Annulus in Predicting Fluid Responsiveness.
Diastolic function may be evaluated by different measurements on transesophageal echocardiography (TEE). They include mitral inflow velocities obtained by pulsed-wave doppler (PW) : peak early diastolic velocity (E) and late…
- Trial name
- NCT02714244
- Testing
- Volume expansion
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Montreal Heart Institute
Hypertrophic Cardiomyopathy
Pirfenidone to Treat Hypertrophic Cardiomyopathy
This study will examine the effectiveness of the drug pirfenidone (Deskar) in improving heart function in patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00011076
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ventricular Dysfunction, Asthma in Children
Evaluation of Cardiac Biomarkers and Ventricular Function in Asthmatic Children
Evaluation of cardiac biomarkers and the left and right ventricular systolic and diastolic function in asthmatic children in Assuit university hospital
- Trial name
- NCT05985720
- Volunteers
- 50 people
- Sponsor
- Assiut University
Heart Failure With Preserved Ejection Fraction
The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)
The purpose of this study is to investigate the effects of colchicine on heart failure related health status, quality of life, and vascular and cardiac function in patients with heart failure with preserved ejection fraction…
- Trial name
- NCT06081049
- Testing
- Colchicine
- Where
- Denmark
- Volunteers
- 152 people
- Sponsor
- Tor Biering-Sørensen
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Renal Dialysis, Hemodiafiltration
Effect of Intradialytic Exercise on Left Ventricular Diastolic Function in Hemodialysis Patients
Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in patients undergoing hemodialysis, largely due to structural cardiac changes associated with left ventricular diastolic dysfunction.
- Conditions
- Renal Dialysis, Hemodiafiltration, Diastolic Dysfunction, Kidney Failure
- Trial name
- EXE-HDF (NCT06584734)
- Testing
- Not exercise, Exercise during hemodiafiltration session
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Type 2 Diabetes Mellitus, Chronic Kidney Disease
Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
Among adult individuals with type 2 diabetes mellitus and at risk for heart failure with impaired relaxation of the heart mildly reduced kidney filtration function (Type 4 cardiorenal syndrome) this trial will evaluate the…
- Conditions
- Type 2 Diabetes Mellitus, Chronic Kidney Disease, Left Ventricular Diastolic Dysfunction
- Trial name
- NCT02251431
- Testing
- BYDUREON
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Baylor Research Institute
Pulmonary Disease, Chronic Obstructive
Effects of Dynamic Hyperinflation on the Left-ventricular Diastolic Function in Healthy Male Subjects
The aim of this study is to identify whether actively induced dynamic hyperinflation can cause left-ventricular diastolic dysfunction in healthy male subjects in order to explore the mechanisms of developing cardiac dysfunctions…
- Trial name
- NCT03500822
- Testing
- Metronome-paced tachypnea, Expiratory-stenosis breathing
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Otto Wagner Hospital
Coronary Heart Disease, Diastolic Dysfunction
Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary Heart Disease
Based on accumulating evidence showing that impaired cardiac energetic metabolism plays important role in the mechanism of cardiac diastolic dysfunction,the study is designed to evaluate whether metabolic modulator treatment with…
- Trial name
- NCT03887013
- Testing
- Trimetazidine
- Where
- China
- Volunteers
- 226 people
- Sponsor
- China National Center for Cardiovascular Diseases
Left Ventricular Diastolic Dysfunction
Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.
The purpose of this research study is to evaluate the effects of cardiac hormone replacement with SQ (subcutaneous or under the skin) injection of BNP (brain natriuretic peptide, a hormone produced by the heart) on the pumping…
- Trial name
- NCT00405548
- Testing
- BNP (nesiritide)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Congestive Heart Failure
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
In congestive heart failure, cardiac output is low, blood pressure is high, and the body becomes congested with fluid. In normal people, when there is high blood pressure, the heart muscle cells secrete a hormone that excretes…
- Trial name
- PPG1 (NCT00387621)
- Testing
- Nesiritide, Saline
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Horng Chen
Erectile Dysfunction, Left Ventricular Diastolic Dysfunction
Association Between Diastolic Dysfunction and Erectile Dysfunction and the Effect of Tadalafil and SGLT2 Inhibitors on Them in Men With Metabolic Syndrome
Metabolic syndrome is associated with an increased risk of cardiovascular disease and is commonly accompanied by erectile dysfunction and subclinical cardiac dysfunction.
- Conditions
- Erectile Dysfunction, Left Ventricular Diastolic Dysfunction, Metabolic Syndrome
- Trial name
- METDDED (NCT07563647)
- Testing
- Tadalafil 5 mg, SGLT-2 inhibitor, Tadalafil plus SGLT2 inhibitors
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University