Clinical trials: Left Ventricular Remodeling
ST Elevation Myocardial Infarction, Remodeling, Left Ventricle
Predictors of Adverse Left Ventricular Remodeling and Final Infarct Size After Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: A Strain Analysis Study Using Echocardiography and Feature Tracking Cardiac Magnetic Resonance
ST-segment elevation myocardial infarction (STEMI) is one of the most important causes of death and disability around the world.
- Trial name
- NCT04773652
- Testing
- speckle tracking echo
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction
Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction
Patients with HOCM and severe LVOT obstruction can remain asymptomatic while significant cellular and structural changes of the heart (adverse remodeling) may occur preceding heart failure and rhythm disorders.
- Conditions
- HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction, Remodeling, Ventricular
- Trial name
- RASTA (NCT04230551)
- Testing
- PTSMA
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- St. Antonius Hospital
Atrial Remodeling, Myocardial Dysfunction
Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation
Sacubitril-valsartan, an Angiotensin Receptor Blocker-Neprilysin Inhibitor (ARNI), currently marketed for the management of heart failure, has been shown to reduce cardiovascular morbidity and mortality in stage C heart failure…
- Conditions
- Atrial Remodeling, Myocardial Dysfunction, Left Ventricular Remodeling, Left Ventricular Diastolic Dysfunction
- Trial name
- PARABLE (NCT04687111)
- Testing
- Sacubitril-Valsartan, Valsartan
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- Mark Ledwidge
ST-segment Elevation Myocardial Infarction, Left Ventricular Remodeling
The Effect of Glucocorticoid Therapy on Left Ventricular Remodelling in Acute Myocardial Infarction (RECONSIDER)
Introduction: In the setting of acute ST-segment elevation myocardial infarction (STEMI) coronary wedge pressure (CWP) emerges as a new marker for the advanced form of pre-procedural microvascular obstruction (MVO), which is…
- Trial name
- RECONSIDER (NCT03371784)
- Testing
- Hydrocortisone
- Where
- Romania
- Volunteers
- 77 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Heart Failure, Left Sided, Left Ventricular Dysfunction
Role of Sacubitril/Valsartan in the Improvement of Heart Failure With Reduced Ejection Fraction
This prospective study evaluates the mechanisms of benefit of sacubitril/valsartan in a population of outpatients with heart failure with reduced ejection fraction, to investigate the relationship between the effects on left…
- Conditions
- Heart Failure, Left Sided, Left Ventricular Dysfunction, Ventricular Remodeling
- Trial name
- NCT04397302
- Testing
- Role of Sacubitril/Valsartan in Hemodynamic and Echocardiographic Improvement of Heart Failure With Reduced Ejection Fraction
- Where
- Italy
- Volunteers
- 652 people
- Sponsor
- Italian Society of Cardiology
Myocardial Infarction, Heart Failure
A Study of VentriGel in Post-MI Patients
This Phase I, open label, study will investigate the effects of VentriGel injection in patients who have experienced a first, large ST elevation myocardial infarction (STEMI) treated by PCI within the past 3 years and have…
- Conditions
- Myocardial Infarction, Heart Failure, Left Ventricular Remodeling
- Trial name
- NCT02305602
- Testing
- VentriGel
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Ventrix, Inc.
Aortic Stenosis, LV Remodeling, Hypertrophy
Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study
Currently, aortic stenosis (AS) is considered a "surgical disease" with no medical therapy available to improve any clinical outcomes, including symptoms, time to surgery, or long-term survival.
- Trial name
- ASPEN (NCT01275339)
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Left Ventricle Remodeling
Long Term Follow Up and Outcome of Left Ventricular Remodeling in ST Segment Myocardial Infarction Patients After pPCI
To detect long-term effects of left ventricular remodeling in STEMI patients undergoing PPCI. And to evaluate outcome.
- Trial name
- NCT03888781
- Testing
- Echocardiography
- Volunteers
- 127 people
- Sponsor
- Assiut University
Acute Coronary Syndrome, Left Ventricle Remodeling
Predictive Value of Risk Scores in Acute Coronary Syndrome
role of different risk scores in acute coronary syndrome to predict left ventricular remodeling
- Conditions
- Acute Coronary Syndrome, Left Ventricle Remodeling, Risk Scores
- Trial name
- NCT03549481
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- shaimaa Mostafa
Left Ventricular Remodeling, Medication Adherence
IMproving reModeling in Acute myoCardial Infarction Using Live and Asynchronous TElemedicine.
The proposed research aims to compare Left ventricular remodeling outcomes among patients with AMI and elevated NT-pro-B-type natriuretic peptide receiving telemedicine-guided post-MI treatment vs.
- Conditions
- Left Ventricular Remodeling, Medication Adherence, Acute Coronary Syndrome
- Trial name
- IMMACULATE (NCT02468349)
- Testing
- Telemedicine
- Where
- 3 sites in Singapore
- Volunteers
- 300 people
- Sponsor
- National University Heart Centre, Singapore
Athletes Heart
Semmelweis Sport Study
The aim of the present proposal is to investigate the development of distinct morphological, functional, biochemical and molecular aspects of short- and long-term sport-induced changes in the heart, to get a better understanding…
- Trial name
- NCT03025737
- Where
- Hungary
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Semmelweis University Heart and Vascular Center
Left Ventricular Remodeling, Acute Myocardial Infarction
Sodium Tanshinone IIA Sulfonate in Left Ventricular Remodeling Secondary to Acute Myocardial Infarction
Approximately 60 patients with ST-segment elevation myocardial infarction successfully treated with primary percutaneous coronary intervention will be enrolled and randomized to receive the sodium tanshinone IIA sulfonate in…
- Trial name
- NCT02524964
- Testing
- sodium tanshinone IIA sulfonate, control
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Left Ventricular Remodeling, Acute Myocardial Infarction
Danlou Tablets to Prevent Left Ventricular Remodeling
Danlou tablets are Chinese patent medicine which has been approved in China for the treatment of ischemic heart disease, but the evidence supporting its efficacy on cardiac remodeling remains unclear.
- Trial name
- NCT02675322
- Testing
- Danlou Tablets
- Volunteers
- 82 people
- Sponsor
- shuai Mao
Myocardial Infarction, Left Ventricular Remodeling
Circulating miR-126 as a Novel Biomarker for Post Myocardial Infarction Remodeling
Purpose: The purpose of this study is to evaluate the impact of circulating miR-126 on left ventricular remodeling and clinical outcomes in patients undergoing primary percutaneous coronary intervention for ST-segment elevation…
- Conditions
- Myocardial Infarction, Left Ventricular Remodeling, miR-126
- Trial name
- PMIR-miR-126 (NCT01875484)
- Where
- 17 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Qilu Hospital of Shandong University
Myocardial Infarction, Left Ventricular Remodeling
Tetracycline (Doxycycline) and Post Myocardial Infarction Remodeling
The aim of the study is to assess the efficacy of an antibiotic treatment with tetracycline (doxycycline) in the early stage of large reperfused acute myocardial infarction (AMI), in preventing left ventricular (LV) remodeling.
- Trial name
- TIPTOP (NCT00469261)
- Testing
- Doxycycline, Current medical therapy for AMI
- Volunteers
- 110 people
- Sponsor
- Careggi Hospital