Clinical trials: Left Ventricular Septal Pacing
Heart Failure, Cardiac Resynchronization Therapy
LVSP Based CRT vs. RVAP Based CRT
To find out whether left ventricular septal pacing (LVSP)-based cardiac resynchronization therapy (CRT) is superior to right ventricular apical pacing (RVAP)-based CRT in patients with failed left bundle branch pacing at the…
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Ventricular Septal Pacing, Right Ventricular Septal Pacing
- Trial name
- NCT05985408
- Testing
- left ventricular septal pacing, right ventricular apical pacing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Cardiac Pacing
Change of QRS Morphology and Electrophysiological Characteristics During Pacing Within the Interventricular Septum
Conduction system pacing (CSP), including His bundle pacing (HBP) and left bundle branch (LBB) pacing (LBBP), as a physiological pacing strategy, can achieve interventricular and/or intra-left ventricular mechanical…
- Trial name
- NCT05557006
- Testing
- left bundle branch pacing
- Where
- China
- Volunteers
- 50 people
- Sponsor
- General Hospital of Shenyang Military Region
Heart Failure, Cardiac Resynchronization Therapy
Left Ventricular Septal Pacing: Potential Application for Cardiac Resynchronization Therapy
In cardiac resynchronization therapy (CRT), biventricular pacing is performed by pacing the right ventricle (RV) and epicardium of the left ventricular (LV) postero-lateral wall.
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Bundle-Branch Block
- Trial name
- NCT03415945
- Testing
- Cardiac resynchronization therapy (CRT)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Maastricht University Medical Center
Cardiac Pacing, Pacing-Induced Cardiomyopathy
LVSP vs RVP in Patients With AV Conduction Disorders
Rationale: Permanent cardiac pacing is the only available therapy in patients with atrioventricular (AV) conduction disorders and can be life-saving.
- Conditions
- Cardiac Pacing, Pacing-Induced Cardiomyopathy, Conduction System Pacing, Left Ventricular Septal Pacing
- Trial name
- LEAP (NCT04595487)
- Testing
- Left ventricular septal pacing, Right ventricular pacing
- Where
- 13 sites in Belgium, Czechia and 5 more
- Volunteers
- 470 people
- Sponsor
- Maastricht University
Left Ventricular Dysfunction, Cardiac Conduction Defect
Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum
Cardiac pacing is the only effective treatment for symptomatic bradycardia. The right ventricular apex (RVA) has become the most frequently used ventricular pacing site.
- Conditions
- Left Ventricular Dysfunction, Cardiac Conduction Defect, Heart Failure, Sick Sinus Syndrome
- Trial name
- NCT01609738
- Testing
- Left ventricular septum pacing lead
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Maastricht University Medical Center
AV Block
Left Septal Pacing or Left Bundle Branch Pacing to Avoid Left Ventricle Systolic Dysfunction
Right ventricular apical pacing (RVAP) can produce left ventricular dysfunction (LVD). Conduction system pacing (CSP) has been used successfully to reverse LVD in patients with left bundle branch block.
- Trial name
- STAY II (NCT06707662)
- Testing
- Pacemaker and defibrillator
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Parc de Salut Mar
Atrio-Ventricular Block
Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block
The aim of this study is to investigate the effects of the right ventricular septal pacing on left ventricular function compared with right ventricular apical pacing.
- Trial name
- NCT00709774
- Testing
- Pacemaker Implantation
- Volunteers
- 60 people
- Sponsor
- Osaka General Medical Center
Heart Failure
A Pilot Study of Interventricular Septal Puncture for Cardiac Resynchronization Therapy to Treat Heart Failure
Cardiac resynchronization therapy (CRT) is known to result in significant improvement in the symptoms of selected patients with heart failure, and to reduce hospital admission and death rates in these patients.
- Trial name
- LV-CONSEPT (NCT01818765)
- Testing
- Trans-ventricular-septal placement of LV pacing lead, Pre-procedure speckle-tracking echocardiography, Acute response assessment
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Oxford University Hospitals NHS Trust
Slow Arrhythmia; Left Bundle Branch Pacing; Cardiac Function
Comparison of Cardiac Function Between Left Bundle Branch Pacing and Right Ventricular Outflow Tract Septal Pacing in Pacemaker-dependent Patients
Permanent pacemaker implantation is a common method for bradycardia and cardiac conduction dysfunction. With the development of physiological pacing, the optimal location of ventricular pacing site is still improving.
- Trial name
- NCT04386473
- Testing
- pacemaker
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruiqin xie
Left Ventricular Dysfunction
PROTECT-PACE STUDY - The Protection of Left Ventricular Function During Right Ventricular Pacing
This study will be done in patients who require the implantation of a cardiac pacemaker (an electronic device that controls the heartbeat) for complete heart block (a heart rhythm abnormality resulting in a slow heart beat).
- Trial name
- PROTECT-PACE (NCT00461734)
- Testing
- RV lead placement site
- Where
- 18 sites in Australia, New Zealand and 1 more
- Volunteers
- 248 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Bradycardia, Atrioventricular Block
Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture
This is a prospective, multicenter, randomized controlled trial designed to determine whether direct capture of the left ventricular conduction system must be achieved as the procedural endpoint of left bundle branch area pacing…
- Conditions
- Bradycardia, Atrioventricular Block, Sick Sinus Syndrome, Cardiac Pacing
- Trial name
- COMPARE-SYNC (NCT07804394)
- Testing
- LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP)
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Heart Block, Sick Sinus Syndrome
Impact of Septal Vs Apical Pacing on Right and Left Ventricular Performance
The study aims to use cardiac MRI scans and analysis techniques to evaluate differences in cardiac function after 12 months of pacing in patients with pacing leads placed in different positions within the right ventricle…
- Conditions
- Heart Block, Sick Sinus Syndrome, Atrioventricular Block, Ventricular Dysfunction
- Trial name
- NCT01798043
- Testing
- Cardiac MRI with pacemaker stimulation, Cardiac MRI with and without pacemaker stimulation
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- Abbott Medical Devices
Cardiomyopathy
Budapest Upgrade CRT Study (Version 009-4.1)
Effect of biventricular upgrade on left ventricular reverse remodeling and clinical outcomes in patient in left ventricular dysfunction and intermittent or permanent apical/septal right ventricular pacing (Budapest CRT upgrade…
- Trial name
- NCT02270840
- Testing
- CRT-D
- Where
- 17 sites in Germany, Hungary and 5 more
- Volunteers
- 360 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Bradyarrhythmia, Heart Failure
Conduction System Pacing International Registry (CONSPIRE)
The purpose of this registry study is to collect information about routine clinical practices with device implantation to treat bradycardia and cardiac systolic dysfunction (heart rhythm disorders) across global centers of…
- Trial name
- NCT04831125
- Testing
- Data collection
- Where
- 8 sites in United States, Netherlands and 2 more
- Volunteers
- 383 people
- Sponsor
- University of Chicago
Complete Heart Block, High Degree Second Degree Atrioventricular Block
Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)
The purpose of the study is to investigate the superiority of chronic left bundle branch area pacing compared to traditional right ventricular (RV) septal pacing in patients with high-grade conduction disease after transcatheter…
- Conditions
- Complete Heart Block, High Degree Second Degree Atrioventricular Block, Pacemaker-Induced Cardiomyopathy, Aortic Valve Stenosis
- Trial name
- NCT05541679
- Testing
- Right ventricular septal pacing followed by left bundle branch area pacing, Left bundle branch area pacing followed by right ventricular septal pacing
- Where
- 4 sites in United States
- Volunteers
- 46 people
- Sponsor
- Main Line Health