Clinical trials: Left Ventricular Systolic Dysfunction
Anemia Treatment Among Patients Suffering From Left Ventricular Systolic Dysfunction
Furosemide Treatment Before Blood Transfusion in Patients With Systolic Dysfunction
The study Objective is to assess the clinical and echocardiographic changes of patients with systolic dysfunction receiving blood transfusion, with or without prior treatment with furosemide
- Trial name
- NCT01705470
- Testing
- furosemide
- Sponsor
- Tel-Aviv Sourasky Medical Center
Heart Failure, Left Ventricular Systolic Dysfunction
Mechanisms and Innovations in Cardiac Resynchronisation Therapy
The aim of this study is to compare the effectiveness of multiple modalities of cardiac resynchronisation therapy using high precision acute electrical and haemodynamic measurements.These modalities include biventricular pacing…
- Conditions
- Heart Failure, Left Ventricular Systolic Dysfunction, Left Bundle-Branch Block, Right Bundle-Branch Block
- Trial name
- MIC (NCT04221763)
- Testing
- His-bundle pacing.
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- Imperial College London
Coronary Artery Disease, Left Ventricular Systolic Dysfunction
Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery
This study aims to investigate whether reduced heart function is associated with differences in stomach contents before elective coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Left Ventricular Systolic Dysfunction, Gastric Contents
- Trial name
- NCT07898215
- Testing
- Gastric Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
Heart Failure, Sleep Disordered Breathing
Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure
The purpose of this trial is to evaluate the long-term effects and cost-effectiveness of adaptive servo-ventilation (ASV) on the mortality and morbidity of patients with stable heart failure due to left ventricular systolic…
- Trial name
- Serve-HF (NCT00733343)
- Testing
- Europe: AutoSet CS (USA: VPAP Adapt SV)
- Where
- 267 sites in Australia, Czechia and 9 more
- Volunteers
- 1,325 people
- Sponsor
- ResMed
Duchenne Muscular Dystrophy, Cardiomyopathy
Nebivolol for the Prevention of Left Ventricular Systolic Dysfunction in Patients With Duchenne Muscular Dystrophy
The objective is to determine whether nebivolol, a beta-blockade drug, can prevent the development of heart disease in patients with Duchenne muscular dystrophy aged 10 to 15 year-old.
- Conditions
- Duchenne Muscular Dystrophy, Cardiomyopathy, Heart Failure
- Trial name
- NEBIDYS (NCT01648634)
- Testing
- Nebivolol
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anterior Acute Myocardial Infarction, Left Ventricular Systolic Dysfunction
STem cElls Mobilization in Acute Myocardial Infarction Outcome Trial
The purpose of this study is to demonstrate that granulocyte colony-stimulating factor (G-CSF) therapy in addition to state-of-the-art treatment (pharmacological and non pharmacological) is safe and significantly improves…
- Trial name
- STEM-AMI (NCT01969890)
- Testing
- G-CSF administration
- Where
- 53 sites in Italy
- Volunteers
- 532 people
- Sponsor
- Heart Care Foundation
Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction
Operative Mitral Valve Reconstruction in Functional mv Insufficiency With Reduced Systolic Ventricle Function
Functional mitral insufficiency poses a challenge with regard to the optimal time of intervention, particularly because they are frequently associated with left ventricular (LV) dilation and reduced LV ejection fraction (EF).
- Conditions
- Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction, Mitral Valve Prolapse
- Trial name
- REFORM-MR (NCT03470155)
- Testing
- mitral valve repair
- Where
- 6 sites in Germany
- Volunteers
- 105 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Coronary Artery Disease, Heart Failure Systolic
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing…
- Trial name
- NCT05427370
- Testing
- Revascularization by PCI, Revascularization by CABG
- Where
- 46 sites in United States, Austria and 14 more
- Volunteers
- 754 people
- Sponsor
- Sunnybrook Health Sciences Centre
Heart Failure
BAY94-8862 Dose Finding Trial in Subjects With Chronic Heart Failure and Mild (Part A) or Moderate (Part B) Chronic Kidney Disease
A placebo (Part A) and placebo and active comparator controlled (Part B), double-blind and randomized study to assess safety and tolerability of a new drug (BAY94-8862) given orally
- Trial name
- ARTS (NCT01345656)
- Testing
- BAY94-8862, Spironolactone
- Where
- 50 sites in Austria, Belgium and 8 more
- Volunteers
- 457 people
- Sponsor
- Bayer
Diabetes
Impact of Diabetes on Left Ventricular Remodeling
The investigators hypothesize that in patients with diabetes and acute myocardial infarction (MI), Ang II type-1 receptor blockade (AT1RB) attenuates left ventricle (LV) remodeling to a greater extent than angiotensin converting…
- Trial name
- P3 (NCT01052272)
- Testing
- Ramipril, Candesartan cilexetil, Allopurinol
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Type 2, Left Ventricular Systolic Dysfunction
Effects of Linagliptin on Left Ventricular Myocardial DYsfunction in Patients With Type 2 DiAbetes Mellitus and Concentric Left Ventricular Geometry
The primary objective of the study is to evaluate the effect of linagliptin 5 mg daily versus the corresponding placebo on the LV systolic function (measured by midwall shortening analysis) in patients with T2DM and a documented…
- Trial name
- DYDA2 (NCT02851745)
- Testing
- Linagliptin
- Where
- 19 sites in Italy
- Volunteers
- 188 people
- Sponsor
- Heart Care Foundation
Induction of General Anesthesia
A Comparison Between Ketamine-lidocaine Versus Ketamine-fentanyl for Induction on the Hemodynamic Effects in Patients With Coronary Artery Disease
Patients with coronary artery disease (CAD) and left ventricular systolic dysfunction (LVSD) presenting for coronary artery bypass grafting (CABG) represent a high-risk group among the cardiac surgical population.
- Trial name
- NCT05502211
- Testing
- Fentanyl, Lidocaine IV
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Kasr El Aini Hospital
Systolic Heart Failure, Beta-blockers Intolerance
Surgical Sympathetic Blockade in Heart Failure
The investigators sought to evaluate the feasibility and safety of surgical sympathetic blockade in systolic heart failure patients and secondary to assess its cardiovascular consequences.
- Conditions
- Systolic Heart Failure, Beta-blockers Intolerance, Beta-blockers Resistance
- Trial name
- SymBlock (NCT01224899)
- Testing
- Left cervico-thoracic sympathetic blockade
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo
Chronic Heart Failure, Iron Deficiency
Intravenous Iron Treatment in Patients With Heart Failure and Iron Deficiency: IRONMAN
This study will address whether the additional use of Intravenous (IV) iron on top of standard care will improve the outlook for patients with heart failure and iron deficiency.
- Conditions
- Chronic Heart Failure, Iron Deficiency, Left Ventricular Systolic Dysfunction
- Trial name
- IRONMAN (NCT02642562)
- Testing
- Ferric Derisomaltose
- Where
- 72 sites in United Kingdom
- Volunteers
- 1,160 people
- Sponsor
- University of Glasgow
Heart Failure, Asymptomatic Systolic Dysfunction
Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function
The following are done for screening procedures to determine if patients are eligible for this study: blood count, kidney and liver blood tests. Patients will complete a 6-minute walk test.
- Trial name
- NCT00405639
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction
Cardiac Energetics and Function in Normal Human Ageing
Normal aging is characterized by altered cardiovascular function. Our preliminary data with MR imaging and spectroscopy in normal subjects without cardiovascular disease or hypertension show that age-related cardiac dysfunction…
- Conditions
- Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction, Ageing
- Trial name
- NCT01504828
- Testing
- Ramipril
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Obstructive Chronic Bronchitis With Acute Exacerbation
STI Combined to Valsalva Maneuver for the Diagnosis of Left Ventricular Dysfunction in COPD Exacerbations
The aim of this investigation was to assess the value of Systolic Time Intervals (STIs) as a method of detecting Left Ventricular Dysfunction (LVD) in patients admitted to the emergency department for cute exacerbations of…
- Trial name
- STICOPD (NCT02481908)
- Testing
- STI measurements at baseline and under Valsalva maneuver
- Where
- Tunisia
- Volunteers
- 189 people
- Sponsor
- University of Monastir
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
Myocardial Injury, LV Dysfunction
Study to Assess Safety and Efficacy of Treating Symptomatic, Ischemic, Chronic Congestive Heart Failure Patients with an LVEF of ≤40% with Fresh, Uncultured, Autologous, Adipose-derived Regenerative Cells Isolated from Lipoaspirate.
To investigate patients suffering from iHF and a LVEF of equal or less than 40% despite best medical treatment safety and efficacy of a single retrograde intra-cardiac venous (i.cv.) injection of UA-ADRCs isolated from…
- Conditions
- Myocardial Injury, LV Dysfunction, Coronary Artery Disease, Heart Failure
- Trial name
- NCT06705023
- Testing
- Uncultured, autologous, adipose-derived regenerative cells (UA-ADRCs), Continuation of patient's best guideline based medical treatment
- Where
- Kazakhstan
- Volunteers
- 36 people
- Sponsor
- Ralf Rothoerl
Left Ventricular Function Systolic Dysfunction
Pacemaker Upgrade to Cardiac Resynchronisation Therapy in Patients With Left Ventricular Dysfunction Dependant Upon Right Ventricular Pacing
Patients with pacemakers often have undiagnosed heart muscle weakness. When a pacemaker battery has run down, it is easily replaced by a short procedure.
- Trial name
- PRE-Empt (NCT01652248)
- Testing
- Cardiac resynchronisation therapy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Leeds