Clinical trials: Leg Injuries
Bimalleolar Ankle Fractures
CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures
The OL1000 is intended to be used as a non-invasive adjunctive treatment for adult males or females that have sustained a closed, unstable ankle fracture that requires surgical treatment for stabilization.
- Trial name
- NCT02688855
- Testing
- Active Combined Magnetic Field OL1000 Bone Growth Stimulator
- Where
- 9 sites in United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Encore Medical, L.P.
Lower Limb Amputation Above Knee (Injury)
The CYBERnetic Lower Limb Cocognitive Ortho-prosthesis Plus Plus, 1st Clinical Study (CLs++)
The aim of the study is to assess the efficacy and the usability of the cyberlegs ++ ortho prosthesis to improve the mobility and the quality of life in transfemoral amputees .
- Trial name
- NCT03376919
- Testing
- CLs++ gait training
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
ACL Injury, ACL Reconstruction
Comparative Effectiveness of Blood Flow Restriction With or Without Total Motion Release in ACL Rehabilitation
The aim of this clinical trial is to compare the effectiveness of combined Blood Flow Restriction (BFR) and Total Motion Release (TMR) versus BFR alone in the restoration of muscular strength, balance and knee functionality in…
- Trial name
- BFR-TMR-ACL (NCT07589309)
- Testing
- Blood Flow Restriction, Total Motion Release
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Green International University
Chronic Ankle Instability, CAI, Ankle Sprain
Validation of a Portable Ankle Arthrometer
The purpose of this study is to assess the validity and reliability of a prototype portable ankle arthrometer in various populations. There are two aims to this study.
- Conditions
- Chronic Ankle Instability, CAI, Ankle Sprain, Healthy
- Trial name
- NCT07163897
- Testing
- Cobra Ankle Arthrometer
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Ankle Sprain
Management of Acute Ankle Sprain With Sodium Hyaluronate
To determine the efficacy and safety of hyaluronic acid (AdantTM, Tedec-Meiji Farma SA) for acute ankle sprain, a single-site, open-label, controlled trial will be conducted.
- Trial name
- NCT02091674
- Testing
- Hyaluronic acid
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Foot Injuries and Disorders
SCANLOAD: The Effect of Limb Loading on Lower Limb Geometry
Orthotists currently use a range of weight bearing conditions when casting or scanning a patient's limb during the Ankle foot orthosis (AFO) fitting process.
- Trial name
- NCT04600102
- Testing
- Structure Sensor
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Iowa
Anterior Cruciate Ligament Tear
Bridge-Enhanced ACL Repair vs ACL Reconstruction
The goal of this trial is to compare the efficacy of the Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR™) technique with the current method of treatment for anterior cruciate ligament (ACL) injuries, ACL reconstruction.
- Trial name
- NCT02664545
- Testing
- BEAR Scaffold, Tendon Graft
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Miach Orthopaedics
Dynamic Balance, Range of Motion, Articular
Using BlazePod® for Pre-Season Screening of Lower Limb Injury Risk
Preventing lower limb injuries is a key concern in sports and physical activities. Even though injury prevention programs and pre-season screening have improved recently, these injuries still happen often.
- Trial name
- NCT07505537
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Surgical Site Infection, Complication of Surgical Procedure
Topical Antibiotics in Surgical Site
Ankle fractures are one of the most common injuries in traumatology. It is the fourth most common fracture in general population after hip, wrist, and hand fractures.
- Trial name
- NCT05363462
- Testing
- Vancomycin 1000 MG
- Where
- Mexico
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Hip Injuries, Hip Fractures
Is the Rate of Early Mobilisation in Hip Fracture Patients Using Alfentanil Better Than Standard Opioid Analgesia?
Hip fracture injuries are linked with increased morbidity, frailty, and mortality risk. Studies have shown that in hip fracture surgery, early mobilisation confers better pain control, 30-day complication and mortality rates and…
- Conditions
- Hip Injuries, Hip Fractures, Pain, Post Operative Pain
- Trial name
- REHAB (NCT06212622)
- Testing
- Alfentanil, Oxycodone
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Anterior Cruciate Ligament, Injuries
Arabic Version of Marx Activity Rating and Knee Stability in Sports/Cutting-Pivoting Ability Scales
Anterior cruciate ligament (ACL) injuries are among the most common knee ligament injuries, causing joint instability and impairments.
- Trial name
- NCT05470790
- Testing
- patient reported outcome measures
- Where
- Saudi Arabia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Diabetic Foot, Leg Ulcer
Obtaining and Storing Standard of Care Wound Biopsies for Immediate or Future Wound-Related Scientific Study
The objective of this study protocol is to use wound biopsies that have been obtained during standard of care management for further scientific evaluation after standard evaluation by a pathologist.
- Conditions
- Diabetic Foot, Leg Ulcer, Decubitus Ulcer
- Trial name
- NCT00759889
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Southwest Regional Wound Care Center
Lower Limb; Fusion, Congenital, Lower Limb Fracture
Investigating Auto Adjusting Dynamic AFO
Offloading Ankle Foot Orthoses (AFOs) are devices designed for people following lower-limb reconstruction to restore mobility by reducing mechanical loading through the injury site and redistributing it proximally.
- Conditions
- Lower Limb; Fusion, Congenital, Lower Limb Fracture, Ankle Foot Injury
- Trial name
- NCT04623853
- Testing
- Variable Stiffness AFO
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Washington
Ankle Sprain
The Effect of Five-Toed Socks on Postural Control Among Active Individuals Who Have Chronic Ankle Instabilities
Lateral ankle sprain (LAS) is one of the most common injuries in sports. There is a unique style of socks that have become popular in Japan among athletes that could also improve postural control.
- Trial name
- NCT01210612
- Testing
- Unilateral CAI
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
ACL Injury
Real-time Sensorimotor Feedback for Injury Prevention in Males Assessed in Virtual Reality
Even though females are 2- to 10-times more likely to suffer an anterior cruciate ligament (ACL) injury, males represent the largest population of total ACL injuries.
- Trial name
- MaNMT (NCT04068701)
- Testing
- MaNMT Biofeedback
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Ankle Sprains, Ligament Sprain
Construction and Validation of a Score Evaluating the Residual Instability of the Patient After Ankle Ligamentoplasty
The goal of this prospective, open label study is the construction and the evaluation of a composite score evaluating the residual instability in patients who have undergone an ankle's ligamentoplasty (the Ankle Go Test score).
- Trial name
- NCT05331365
- Testing
- Construction and evaluation of a composite score evaluating post ankle surgery residual instability by completing questionnaires and undergoing physical tests
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Elsan
Syndesmotic Injuries, Ligament Rupture
Internal Brace Augmented Anterior Inferior Tibiofibular Ligament Repair: Post-operative Syndesmotic Volumes.
Over the course of a year from the start of the research study, twenty subjects will be randomized evenly into one of two groups after an informed consent is obtained: a traditional tight rope fixation group or a tight rope…
- Conditions
- Syndesmotic Injuries, Ligament Rupture, Bimalleolar Fractures, Trimalleolar Fractures
- Trial name
- NCT05062265
- Testing
- Tight rope fixation, Tight rope fixation with an anterior inferior tibiofibular ligament (AITFL) repair augmentation with an internal brace
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vann Virginia Center for Orthopaedics dba Atlantic Orthopaedic Specialists
ACL Injury Prevention
Effect of Specific ACL Injury Prevention Training in Female Handball Players
The anterior Cruciate Ligament (ACL) injuries rates in female handball are high, particularly among adolescents. Therefore, the primary purpose of this randomized control trial is to explore the effects of an 8-week ACL injury…
- Trial name
- NCT05955599
- Testing
- ACL Injury Prevention Training, Control - Shoulder Injury Prevention Training
- Where
- 3 sites in Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Arthrometry and Clinical Tests for Diagnosing ACL Tears
Anterior cruciate ligament (ACL) tears are diagnosed by combining the patient's history and physical examination but clinical tests (e.g., Lachman, anterior drawer, and pivot shift) are less accurate within the first three weeks…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05416632
- Testing
- Athrometer
- Where
- 2 sites in United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Coronary Heart Disease, Stroke
Examining the Long-Term Risks of Oophorectomy
At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.
- Conditions
- Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer
- Trial name
- NCT00655447
- Where
- United States
- Volunteers
- 32,175 people, healthy volunteers welcome
- Sponsor
- Parker, William H., M.D.