Clinical trials: Leg Lymphedema
Venous Stasis Ulcer, Quality of Patient Care
Venous Leg Ulcer and Lymphedema Registry
This is an observational, longitudinal real world registry of venous leg ulcers created from electronic health record data obtained in the course of clinical care.
- Trial name
- VLULR (NCT02813187)
- Testing
- cellular and tissue based therapy, debridement, advanced wound therapy
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- U.S. Wound Registry
Lymphoedema
Intermittent Pneumatic Compression for Treating Lower Limb Lymphoedema
The treatment of lymphoedema and its associated complications represent a considerable drain on increasingly limited NHS resources.
- Trial name
- IMPRESS (NCT03825263)
- Testing
- Intermittent Pressure Compression
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of South Wales
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 5
This clinical study evaluates the reliability, concurrent validity, and clinical feasibility of a new method to determine leg volume, namely the Structure Sensor Scanner.
- Trial name
- EvaLymph-Leg5 (NCT07017166)
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphedema, Lipedema
Multimodal Ultrasound for Differentiating Lymphedema and Lipedema
The aim of this observational study is to evaluate the diagnostic value of multimodal ultrasonography in differentiating between lymphedema and lipedema.
- Trial name
- NCT07489248
- Testing
- Multimodal Ultrasound Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Lymphedema
Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema
This is a randomized, controlled, parallel group, open label, clinical trial to evaluate the effectiveness of intermittent, gradient, pneumatic compression (IPC)on the healing of venous ulcers in subjects diagnosed with chronic…
- Trial name
- NCT01079299
- Testing
- Intermittent, gradient, pneumatic compression device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Calvary Hospital, Bronx, NY
Lymphedema
Comfort Subcutaneous Drainage: a Descriptive Study Among Palliative Phase Cancer Patients
Physical embarrassment, pain and psychological impact linked to the body image distortion are often associated to these lymphedemas.
- Trial name
- NCT02494115
- Testing
- subcutaneous drainage
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Uterine Cervical Neoplasms, Endometrial Neoplasms
Early Intervention to Prevent Lower Limb Lymphedema of Gynecological Malignancy
This study is a prospective, randomized, controlled clinical trial of a single center in China and plans to enroll 400 patients. 1.
- Conditions
- Uterine Cervical Neoplasms, Endometrial Neoplasms, Lymphedema, Treatment Effectiveness
- Trial name
- NCT05793749
- Testing
- Prophylactic lymphedema treatment
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chongqing University Cancer Hospital
Primary Lower Limb Lymphedema, Secondary Lower Limb Lymphedema
Pilot Efficacy Study of the Stendo Pulsating Suit in Patient With Leg Lymphoedema
This study aims at evaluating the efficacy of the Stendo pulsating suit in patients with a leg lymphedema hospitalized for intensive Complex Decongestive Physiotherapy (CDP).
- Trial name
- NCT02234674
- Testing
- Current intensive CDP, intensive CDP where Stendo pulsating suit replaces pressotherapy
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Stendo
Lymphedema
Comparative Trial to Monitor Interface Pressure in Relation to Volume Change in Leg Lymphoedema
Although there is no doubt about the need for compression therapy in lymphoedema, it is not investigated in much detail how much pressure is needed to get optimum volume reduction.
- Trial name
- NCT01828606
- Testing
- coban 2 system, coban lite system
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 60 people
- Sponsor
- Nij Smellinghe Hosptial
Lymphedema
Assessment of Unilateral Lymphoedema of the Leg
To demonstrate that ImpediMed L-Dex U400 can be used to assess unilateral Lymphoedema of the leg using the same principles for arms.
- Trial name
- NCT00757406
- Where
- Australia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- ImpediMed Limited
Lymphedema, Lower Limb
Correlation Between Volume and Pain in Lower Limbs Lymphoedema
The vascular physiotherapy department of the UCL University Clinics of Mont-Godinne specializes in the physiotherapeutic management of lymphoedema.
- Trial name
- NCT06145204
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 79 people
- Sponsor
- University Hospital of Mont-Godinne
Lower Extremity Lymphedema
Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment
The goal of this pilot study is to learn if a revised method of compression improves lymphatic function compared to the current method of compression.
- Trial name
- NCT07613931
- Testing
- Advanced pneumatic compression device (APCD), Advanced pneumatic compression device (APCD) with revised compression programming, Indocyanine Green (IC-Green)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Tactile Medical
Lymphedema
Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema
Lymphedema affects millions and currently lacks effective drug treatments, relying mainly on compression therapy. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown potential in managing obesity and diabetes, which…
- Trial name
- NCT07012642
- Testing
- GLP-1 Receptor Agonists
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Advanced Reconstructive Surgery Alliance
Lymphedema, Lower Limb
Can the Osteopathic Pedal Pump Reduce Lymphedema in the Lower Extremities in the Elderly? A Mentorship Project.
Chronic lymphedema is defined as swelling or edema (excess fluid in the interstitial space) that does not fully resolve overnight by elevating the limb or body part to the level of the heart.
- Trial name
- NCT05119517
- Testing
- Osteopathic manipulative medicine pedal pump
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rowan University
Lymphedema
Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema
Juxta-Fit is used for compression treatment. Juxta-Fit is an inelastic compression device which can be easily adjusted to the circumference of the limb and is usually used during the maintenance phase of lymphedema treatment.
- Trial name
- NCT01068431
- Testing
- bandaging with trico as active controller
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Nij Smellinghe Hosptial
Lymphedema, Lymphedema Lower Extremity
Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of Koya Dayspring Active Wearable Compression Technology for Treating Lower Extremity Lymphedema
- Conditions
- Lymphedema, Lymphedema Lower Extremity, Chronic Venous Insufficiency, Secondary Lymphedema
- Trial name
- TIBER (NCT04897035)
- Testing
- Dayspring Active Wearable Compression System
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Koya Medical, Inc.
Lower Limb Lymphedema, Unilateral Leg Edema
Effects of Hydrotherapy on Unilateral Lower Extremity Lymphedema
Lymphedema is a chronic condition that negatively affects patients' quality of life and lower extremity functions, causing swelling and a feeling of heaviness in the extremity, as well as posing an economic burden.
- Trial name
- NCT06839885
- Testing
- Interventional group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Lower Limb Lymphedema
Use of the Unstable Shoes in Lower Limb Lymphedema.
Lymphedema is an external manifestation of lymphatic system insufficiency and deranged lymph transport. It is defined as accumulation in the extracellular space of protein-rich fluid, due to a mechanical failure of the lymphatic…
- Trial name
- NCT05996939
- Testing
- To compare the efficacy of unstable shoes with that of conventional sports shoes in people with lower-limb primary and secondary lymphedema.
- Volunteers
- 26 people
- Sponsor
- Universidad Europea de Madrid
Lower Extremity Lymphedema
Platelet Rich Plasma, Complex Decongestive Physiotherapy and Low Level Laser in Treatment of Lower Extremity Lymphoedema
At the end of the study, comparative information about the effects of PRP, complex decongestive physiotherapy and low level laser on edema volume, range of motion, muscle strength, functional capacity and quality of life will be…
- Trial name
- NCT03080207
- Testing
- PRP method, Low Level Laser, Complex Decongestive Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group