Clinical trials: Leg Lymphedema
Lymphedema, Lymphoedema
Effect of Lymphovenous Anastomosis on Lower Limb Lymphedema: Pragmatic Randomized Controlled Trial
This multicentre pragmatic randomised controlled trial evaluates lymphovenous anastomosis (LVA) for lower-limb lymphedema (LLL) in Denmark.
- Conditions
- Lymphedema, Lymphoedema, Lymphoedema of Leg, Lymphedema of Leg
- Trial name
- NCT07073586
- Testing
- Lymphovenous Anastomosis, Complete Decongestive Therapy
- Where
- 2 sites in Denmark
- Volunteers
- 66 people
- Sponsor
- Herlev and Gentofte Hospital
Lymphedema, Lymphedema, Lower Limb
Effects of Aerobic Cycling Training in Patients With Gynecologic Cancer-related Lower Extremity Lymphedema
Comparison of complete decongestive treatment and complete decongestive treatment + cycling ergometry treatment in patients with gynecologic cancer-related lower extremity lymphedema in terms of quality of life, lower extremity…
- Conditions
- Lymphedema, Lymphedema, Lower Limb, Gynecologic Cancer
- Trial name
- NCT06200948
- Testing
- Aerobic Exercise, Complete Decongestive Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Ankara City Hospital Bilkent
Lower Extremity Lymphedema
Diaphragmatic Exercises and Fascial Release Techniques on the Treatment of Lower Extremity Lymphedema
The aim of this study is to determine the effect of multidimensional breathing exercises and fascial release techniques performed in addition to the conventional treatment program on the treatment of lymphatic fluid in women with…
- Trial name
- NCT05483569
- Testing
- Complex Decongestive Physiotherapy, Multidimensional Diaphragmatic Breathing Exercises, Facial Release Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Medeniyet University
Leg Lymphedema
Comparative Trial in Compression Therapy in Leg Lymphedema
The purpose of this trial is to study the effect of the 3M Coban 2 Layer Compression System (hereafter C2L) in the treatment of leg lymphedema compared to the traditional treatment with Trico bandages.
- Trial name
- NCT00665379
- Testing
- Regular Compression therapy (Trico bandages), New Compression therapy (C2L bandages)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Nij Smellinghe Hosptial
Lymphedema, Stage IA Cervical Cancer
Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer
This clinical trial studies lymphedema after surgery in patients with endometrial cancer, cervical cancer, or vulvar cancer. Collecting information over time about how often lymphedema occurs in patients undergoing surgery and…
- Conditions
- Lymphedema, Stage IA Cervical Cancer, Stage IA Uterine Corpus Cancer, Stage IA Vulvar Cancer
- Trial name
- LEG (NCT00956670)
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Study of High Risk Factors
- Where
- 213 sites in United States
- Volunteers
- 1,055 people
- Sponsor
- Gynecologic Oncology Group
Lymphedema, Secondary, Lymphedema of Upper Limb
LymphoPilot Test for Limb Lymphedema
The present study is a first-in-man, single arm, open-label, single center study to assess feasibility and safety of a novel implantable device, LymphoPilot, in patients suffering from secondary upper limb or lower lymphedema.
- Conditions
- Lymphedema, Secondary, Lymphedema of Upper Limb, Lymphedema Arm, Lymphedema of Leg
- Trial name
- NCT04858230
- Testing
- LymphoPilot
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Lymphatica Medtech SA
Lymphedema of Leg, Gynecologic Cancer
Effectiveness of Two Exercises in Preventing Lower-Limb Lymphedema After Gynecological Cancer Surgery
Background: Lower-limb lymphedema is one of the complications after gynecological cancer surgery. Patients with lymphedema are more likely to limit their daily life activities and become inactive, leading to negative influences…
- Conditions
- Lymphedema of Leg, Gynecologic Cancer, Exercise
- Trial name
- NCT05666947
- Testing
- Home-based exercise
- Volunteers
- 60 people
- Sponsor
- Yu-Yun Hsu
Lymphedema, Lower Limb, Extracorporeal Shock Wave Therapy
Extracorporeal Shock Wave Therapy in Lower Extremity Lymphedema
Lower extremity lymphedema is a chronic and progressive condition associated with significant functional impairment and reduced quality of life.
- Conditions
- Lymphedema, Lower Limb, Extracorporeal Shock Wave Therapy, Edema Leg, Sham-controlled
- Trial name
- NCT07626645
- Testing
- Extracorporeal Shock Wave Therapy (ESWT)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gazi University
Gynaecological Malignant Tumours With Indication of Pelvic Lymphadenectomy
Lower-Limb Drainage Mapping in Pelvic Lymphadenectomy for Gynaecological Cancer
The purpose of this study is to evaluate the feasibility of an isotopic technique to identify, and to map the lower-limb drainage nodes during pelvic lymphadenectomy for gynaecological cancers.
- Trial name
- SENTIJAMBE (NCT01946672)
- Testing
- Lower-limb drainage isotopic intraoperative detection
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lower Extremity Lymphedema
Daphnetin Capsules for Lower Limb Lymphoedema Following Gynaecological Surgery
This clinical trial is designed to learn more about treating patients with lower limb lymphoedema following gynaecological surgery.
- Trial name
- NCT06329167
- Testing
- Daphnetin, Aescuven
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Jilin University
Endometrial Cancer, Lymphedema
Prevalence of Self Reported Lymphedema in Patients With Endometrial Cancer
The investigators are interested in understanding how the patient has been doing since their surgery for endometrial cancer and if they are experiencing any symptoms related to lymphedema (swelling) in the your lower body.
- Trial name
- NCT02912767
- Testing
- questionnaire
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lymphedema of Leg, Lymphedema, Secondary
Imaging Sodium and Lymphatics in Lymphedema
Recent evidence supports lymphatic regulation of tissue sodium handling, however fundamental gaps persist in knowledge regarding the role of lymphatics in human diseases of sodium dysregulation.
- Conditions
- Lymphedema of Leg, Lymphedema, Secondary, Lymphedema Related Fibrosis
- Trial name
- NCT05242900
- Testing
- Complete decongestive therapy, Standard imaging protocol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Virginia
Gynecologic Cancer-related Lower Extremity Lymphedema, Lymphedema
Comparative Efficacy of 3L and 2L Integrated Techniques for Gynecologic Cancer-related Lower Extremity Lymphedema: a Retrospective Study
The goal of this retrospective study is to evaluate the long-term efficacy of 3L versus 2L integrated techniques in patients with gynecologic cancer-related lower extremity lymphedema (GCR-LEL).
- Trial name
- NCT06920732
- Testing
- VLNT（Vascularized Lymph Node Transfer）, LVA（Lymphaticovenular Anastomosis）, LS（Liposuction）
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Zunyi Medical College
Cellulitis/Erysipelas of the Leg
RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg
To assess whether a period of prophylactic penicillin after an episode of cellulitis of the leg reduces the risk of repeat episodes. Participants are randomised to receive 12 months of prophylaxis (penicillin VK 250mg b.d.
- Trial name
- PATCH1 (NCT00552799)
- Testing
- Penicillin VK
- Where
- 25 sites in Ireland, United Kingdom
- Volunteers
- 274 people
- Sponsor
- University of Nottingham
Lymphedema of Leg, Cancer of Cervix
High Intensity Interval Training (HIIT) for Patients With Cancer-related Lymphedema in the Lower Limbs
The aim of the study is to explore the feasibility and safety of High Intensity Interval Training on a stationary bike for patients with lymphedema in the lower limbs and the role of compression garments during exercise.
- Conditions
- Lymphedema of Leg, Cancer of Cervix, Cancer, Ovarian, Cancer, Endometrial
- Trial name
- NCT03653819
- Testing
- First exercise session + compression, First exercise session - compression
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Herlev and Gentofte Hospital
Mastectomy Related Lymphedema, Lymphedema of Upper Limb
Testing an Intervention to Foster Hope for Cancer Survivors With Lymphedema
The specific objectives and research questions of the proposed study are: 1. a. Administer a group rehabilitation intervention to address loss and foster hope in 30 participants with upper and lower limb SLC --15 in an…
- Conditions
- Mastectomy Related Lymphedema, Lymphedema of Upper Limb, Lymphedema of Lower Extremity
- Trial name
- NCT02453295
- Testing
- Intervention Group
- Volunteers
- 60 people
- Sponsor
- University of Ottawa
Lymphedema of Limb, Sentinel Lymph Node
Early Detection of Lower Extremity Lymphedema After Lymphadenectomy in Gynecological Cancer
This study aims to detect and treat early lower limb lymphedema secondary to lymphadenectomy with the aim of increasing the quality of life of patients with this chronic condition.
- Trial name
- NCT03917771
- Testing
- Early lymphedema detection, Usual follow-up
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Donostia
Lower Extremity Lymphedema
Respiratory and Relaxation Training in Lower Extremity Lymphedema
This randomized controlled trial aims to investigate the effectiveness of respiratory and relaxation training added to standard complex decongestive therapy (CDT) on muscle oxygenation, functional capacity, and limb volume in…
- Trial name
- NCT07697482
- Testing
- Complex Decongestive Therapy, Respiratory and Relaxation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Toros University
Lymphedema of Leg
Hydrophobic Tubes for the Treament of Lower and Upper Limb Lymphedema
Lymphedema is a chronic condition causing fluid buildup in affected limbs. Traditional treatments often fall short, but subcutaneous implantation of hydrophobic silicone tubes shows promise, creating artificial drainage pathways.
- Trial name
- NCT05970068
- Testing
- implantation of hydrophobic tubes for edema fluid drainage, Best Medical Treatment
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Universidade do Porto
Lymphedema of Leg, Sensitisation
Effects of Complex Decongestive Therapy on Proprioception, Balance and Tactile Sense
The aim of this study is to investigate the effects of complex decongestive physiotherapy (CDP) on propriseception, balance and sensation in patients with secondary lymphedema that develops in the lower extremities after cancer…
- Conditions
- Lymphedema of Leg, Sensitisation, Balanced, Therapy-Associated Cancer
- Trial name
- NCT06204510
- Testing
- complex decongestive therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Selcuk University