Clinical trials: Leg Swelling
Pain, Acute, Pain, Chronic
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function
- Conditions
- Pain, Acute, Pain, Chronic, Knee Injuries, Knee Osteoarthritis
- Trial name
- NCT05886608
- Testing
- AI 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Swelling/ Edema
The Efficacy and Safety of Venostan in Promoting Postoperative Swelling Reduction in Patients With Ankle Fractures
This study is a multicenter, open-label, randomized controlled trial planned to enroll patients with ankle fractures who meet the inclusion and exclusion criteria and are scheduled to undergo internal fixation surgery from the…
- Trial name
- NCT06872034
- Testing
- Venostasin (horse chestnut seed extract tablets), standard treatment
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Beijing Jishuitan Hospital
Ankle Fractures, Swelling
Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchathani
The use of evaporative coolants in the management of acute musculoskeletal injury has received increasing attention recently. However, its efficacy compared with conventional cryotherapy in treating injured human subjects remains…
- Conditions
- Ankle Fractures, Swelling, Cryotherapy Effect
- Trial name
- 3-armRCT (NCT06293209)
- Testing
- 3M cold pack, Perskindol cold spray
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thai Traditional Medical Knowledge Fund
Total Knee Arthroplasty, Venous Insufficiency of Leg
Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty
The goal of this clinical trial is to find out the efficacy of diosmin and hesperidin on postoperative early rehabilitation after primary total knee arthroplasty.
- Trial name
- NCT06753448
- Testing
- Diosmin and Hesperidin Combination
- Where
- Turkey (Türkiye)
- Volunteers
- 190 people
- Sponsor
- Ankara Etlik City Hospital
Osteoarthritis (OA) of the Hip
TED Stocking vs. Reparel Garment After Hip Replacement
This randomized, prospective study compares the effectiveness of a novel bioactive garment (Reparel Leg Sleeve) versus standard TED compression stockings in reducing postoperative leg swelling, pain, and deep vein thrombosis…
- Trial name
- NCT07246200
- Testing
- Reparel Bioactive Sleeve, TED Stocking
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Reparel
Knee Osteoarthritis, Arthroplasty Complications
The Whole Body Vibration Training for Total Knee arthroplasty-the Improvement of the Lower Limb
Knee Osteoarthritis in elder cause pain and decrease their functional activity. After conservative rehabilitation failure, they might receive total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Arthroplasty Complications, Swelling; Leg
- Trial name
- NCT04107350
- Testing
- whole-body vibration
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Ankle Fracture, Ankle Arthrodesis
Compression Therapy for Swelling Management Following Ankle Injury
After an injury or undergoing foot/ankle surgery, patients often experience swelling in the injured area. Under current standard of care, plaster casts are removed at six weeks and patients are put in a walking boot.
- Trial name
- NCT06772649
- Testing
- Compression sleeve
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Deep Vein Thrombosis, DVT
DVT Ultrasound in the Emergency Department
Emergency Medicine (EM) Residents routinely conduct bedside ultrasound exams in the Emergency Department (ED) employing the two point compression method.
- Trial name
- NCT02369263
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Emergency Medicine Physicians, Nevada
Lymphedema
Quality of Life Changes on Lower Extremity Lymphedema Patients Using an Advanced Pneumatic Compression Device (PCD)
Assessment of quality of life and symptoms changes in primary or secondary, unilateral or bilateral lower extremity lymphedema patients using an advanced pneumatic compression system.
- Trial name
- NCT02661646
- Testing
- Advanced Pneumatic Compression Device
- Where
- 6 sites in United States
- Volunteers
- 249 people
- Sponsor
- Tactile Medical
Hypertension
A Study to Evaluate Methodologies for Measuring Swelling of the Leg and Ankle (MK-0000-106)(COMPLETED)
This study will evaluate methodologies for measuring pedal edema associated with calcium channel blockers in middle-aged and elderly subjects and patients with hypertension.
- Trial name
- NCT00789321
- Testing
- Comparator: amlodipine besylate
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Knee; Injury, Meniscus (Lateral) (Medial), Meniscus Tear
Clinical Efficacy of Exosome in Degenerative Meniscal Injury
Comparison of intra-articular administration of synovial fluid-derived mesenchymal stem cells-derived exosomes with synovial fluid-derived mesenchymal stem cells on the same patient.
- Conditions
- Knee; Injury, Meniscus (Lateral) (Medial), Meniscus Tear, Meniscus Lesion, Meniscus; Degeneration
- Trial name
- KNEEXO (NCT05261360)
- Testing
- SF-MSC-EX, SF-MSC
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Varicose Vein of Lower Limbs
Catheter-directed Foam Sclerotherapy With Tumescence
Foam sclerotherapy has been established as another option of treatment for varicose veins of the lower limbs. Its advantages are the application to patients with high surgical risk and immediate return to usual activities.
- Trial name
- NCT02753270
- Testing
- Short catheter, Long catheter preceded by tumescence
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Venous Insufficiency
Clinical Study of BNS003 on Swelling in Legs Due to Venous Reflux
To investigate the efficacy and safety of BNS003 on subjective symptoms such as sensation of heaviness/tiredness(dullness), tension, tingling, pain, fever or itching associated with swelling of calf and ankle due to disorder of…
- Trial name
- NCT02211898
- Testing
- BNS003
- Volunteers
- 180 people
- Sponsor
- Boehringer Ingelheim
Edema
Mild Compression Sock for Control of Lower Extremity Edema in Individuals With Diabetes
The purpose of this study is to determine whether a specially designed sock for people with diabetes and swelling in the legs can reduce the swelling, improve blood flow to the legs, and improve physical activity patterns of…
- Trial name
- NCT01529385
- Testing
- mild compression diabetic sock, Standard diabetic sock
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rosalind Franklin University of Medicine and Science
Varicose Veins
Evaluation of Endovenous Sclerotherapy for Treatment of Varicose Veins
The overall objective will be to evaluate clinical predictors of outcomes in patients who undergo endovenous sclerotherapy for the treatment of varicose veins.
- Trial name
- NCT00954980
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Lymphedema
Lymphedema Study for Arm or Leg Lymphedema
This study compares the effectiveness of a study drug versus placebo in the treatment of lymphedema.
- Trial name
- NCT02257970
- Testing
- Ketoprofen
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Stanford University
Ankle Fractures
Unna Boots for Ankle Fracture Swelling
This study will evaluate the difference in soft tissue swelling prior to surgery and wound complications after surgery between unna boot application versus standard splint application.
- Trial name
- NCT04086927
- Testing
- Unna Boot
- Sponsor
- Medical University of South Carolina
Lower Extremity Swelling, Lower Extremity Edema
Game-Based Foot & Ankle Exercise for Those With Lower Extremity Edema
The present study aims to use a game-based tele-exercise program for patients using a compression garment to improve lower extremity edema.
- Conditions
- Lower Extremity Swelling, Lower Extremity Edema, Venous Insufficiency of Leg
- Trial name
- NCT05520008
- Testing
- Game-based exercise
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
May-Thurner Syndrome
The Use and Reproducibility of Duplex Ultrasound to Provide Indices of Left Common Iliac Vein Diameter
The goal of this feasibility/pilot study is to investigate whether or not vascular ultrasound can be used to aid the diagnosis of May Thurner Syndrome, in adult patients presenting to the vascular department with unexplained left…
- Trial name
- NCT06180122
- Testing
- Duplex ultrasound
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College London
Limb Edema, Surgical Site Infections
Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages
The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients.
- Conditions
- Limb Edema, Surgical Site Infections, Leg Swelling, Compression Bandages
- Trial name
- PEACCE (NCT06603961)
- Testing
- CPG-EB group
- Where
- 2 sites in Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital