Clinical trials: Lens Disease
Astigmatism, Cataract
Femtosecond Laser Assisted Keratotomies for the Management of Corneal Astigmatism
A cataract is a clouding of the lens that occurs naturally with age. Cataract surgery involves removal of the cloudy lens and replacement with an artificial one.
- Trial name
- NCT04676451
- Testing
- Femto-AK
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Milton S. Hershey Medical Center
Cataract
Light Filters in Intraocular Lenses (IOLs) and Its Influence on Colour and Contrast Vision.
Visible-light-filtering IOLs are implanted increasingly often in cataract surgery. Several studies examined the effect of light-filters on contrast and colour vision. However, the study outcomes were varying.
- Trial name
- NCT00612729
- Testing
- Polylens Y30 intraocular lens, Orange Series Model PC 440 Y intraocular lens
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Hospital Hietzing
Patients With Systemic Inflammatory Diseases Receiving for the First Time a Protracted General Corticostroid Therapy
Impact of Systemic Corticosteroid Therapy on Lens Transparency and Quantification of Lens Autofluorescence.
Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking.
- Trial name
- NCT00337623
- Testing
- Prednisolone
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Cataract
Clinical Study - ES 900 - 2020-1
EYESTAR 900 is a device developed by Haag-Streit which utilises 3D OCT for quantitative measurements of the geometry of the entire eye, including ocular biometry and corneal topography.
- Trial name
- NCT05304182
- Testing
- EYESTAR 900, LENSTAR LS 900
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Haag-Streit AG
Cataract, Phakic Intraocular Lens Explantation
Molecular Background of Endothelial Cell Loss in Patients With Phakic Intraocular Lenses: a Tear and Aqueous Humour Analysis Study
Rationale: The number of highly myopic patients is increasing. Especially in East and Southeast Asia, up to 90% of adolescents are currently myopic.
- Trial name
- MoBack (NCT04174924)
- Testing
- Phakic intraocular lens (pIOL) explantation
- Where
- Netherlands
- Volunteers
- 126 people
- Sponsor
- Maastricht University Medical Center
Astigmatism
Clinical Performance of Habitual Hydrogel vs. Silicone Hydrogel Toric Contact Lenses
Evaluate the clinical performance of existing wearers of hydrogel toric lenses when refitted with Avaira toric silicone hydrogel contact lenses over 1 week of wear.
- Trial name
- NCT02142361
- Testing
- enfilcon A
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- CooperVision, Inc.
Ametropia
One-month Clinical Evaluation of Silicone Hydrogel Definitive 65 HPT Contact Lenses
Comparison of different contact lens materials.
- Trial name
- NCT02312323
- Testing
- Definitive 65 HPT contact lenses, Definitive 65 contact lenses
- Where
- 2 sites in Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Contamac Ltd
Cataracts
Safety and Effectiveness of the Calhoun Vision Light Adjustable Intraocular Lens (LAL)
The primary objective of this study is to evaluate, for the visual correction of aphakia, the safety and effectiveness of the Calhoun Vision Light Adjustable intraocular lens (LAL) and Light Delivery Device (LDD) in treating…
- Trial name
- NCT00845520
- Testing
- Lens implantation +1.00 D postop target, Lens implantation -1.00 D postop target, Lens implantation 0.00 D postop target
- Where
- 6 sites in United States, Mexico
- Volunteers
- 74 people
- Sponsor
- Calhoun Vision, Inc.
Cataract
Visual Acuity Outcome Differences Between the Alcon Vivity Toric IOL and RxSight LAL+
Phase 1 will be ambispective, multi-site, single arm study in age-related cataract patients with regular astigmatism, who were bilaterally treated with the LAL+ IOLs Phase 2 will be a prospective, randomized, unmasked…
- Trial name
- NCT06574646
- Testing
- LAL+, Clareon Vivity Toric IOL
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The Eye Associates
Cataract
Bioequivalence of Eye Drops and Spray Administration of Vigamox
The study compares the amounts of Vigamox absorbed when administered as eye drops or in a spray form. Both administrations will be prior to patients undergoing elective cataract surgery and the aqueous samples will be analyzed by…
- Trial name
- NCT00666042
- Testing
- Vigamox - administration in spray form, Vigamox eye drops
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Advanced Ophthalmic Pharma
Myopia, Progressive
Choroidal Response to Novel Spectacle Lens to Control Myopia Progression
Diurnal variations in the thickness of the choroid have been reported in the literature, and, more recently, the role of the choroid has been studied with respect to its role in myopia (near-sightedness) progression.
- Trial name
- CHERRY (NCT03818880)
- Testing
- Novel spectacle lens design
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Cataract
Night Driving Pilot
Pilot study to evaluate usability of Mesotest II for assessment of night driving capacity of pseudo-phakic patients implanted with aspheric monofocal posterior chamber IOL *AT.Smart 46LC.
- Trial name
- NCT00876278
- Testing
- *AT.Smart 46LC
- Where
- Germany
- Sponsor
- Carl Zeiss Meditec AG
Cataract, Astigmatism
Observational Prospective Clinical Investigation on Monofocal Toric Intraocular Lens
Evaluation, at least one-year long-term, of the clinical performance and safety of Mini Toric Ready Intraocular Lens (IOL), a monofocal toric intraocular lens.
- Trial name
- NCT06250855
- Testing
- Mini Toric IOL
- Where
- 2 sites in Romania
- Volunteers
- 105 people
- Sponsor
- SIFI SpA
Cataract
Bypassing Anesthesiologist Assessment Before Cataract Surgery: a Non Inferiority Study
This study aims to demonstrate that presurgical assessement of patients' risk factors and surveillance during surgery, both performed by nurses, are not inferior to anesthetic team's care, concerning the rate of complications in…
- Trial name
- CATARIDE (NCT02903485)
- Testing
- nurses perform presurgical assessement and surveillance during surgery, the anesthetic team performs presurgical assessement and surveillance during surgery
- Where
- France
- Volunteers
- 578 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Presbyopia, Low Vision
Ocular Biomarkers for Successful Premium Trifocal Intra-ocular Lenses Implantation
The purpose of this study is to identify ocular biomarkers that can predict the success of phacoemulsification with bilateral AT LISA try 839MP (Carl Zeiss Meditec AG) implantation to achieve satisfactory post-post-operativly…
- Trial name
- NCT05863247
- Testing
- Patient Reported Outcomes / Biometric data revision
- Where
- Portugal
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Hospital dos Lusíadas
Pseudoexfoliation Syndrome in Cataract Myopic Eyes
Pseudoexfoliation Syndrome in Myopes
A retrospective study of 5753 eyes of cataract surgery patients was conducted at our Clinic. Ocular optical components measured by optical low coherence reflectometry biometer LENSTAR LS 900® of the cataract myopic eyes with…
- Trial name
- NCT01637740
- Volunteers
- 5,753 people
- Sponsor
- General Hospital Sveti Duh
Myopia Progressing
3D Designed Defocus Lenses on Myopia Control in Children and Adolescents
This study aims to evaluate the effectiveness of lenses with 3D Designed Defocus in controlling the progression of myopia in children and adolescents, and to explore the feasibility of effective design, and apply personalized…
- Trial name
- NCT07284147
- Testing
- Defocus Lenses
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Cataract, Astigmatism
Assessing the Astigmatism Reducing Effect With Toric IOLs in Eyeswith Low Astigmatism
Comparison of the astigmatism reducing effect of a toric IOL with a non toric IOL in eyes with low corneal astigmatism.
- Trial name
- Low Asti (NCT03538964)
- Testing
- toric intraocular lens, non toric intraocular lens
- Where
- Austria
- Volunteers
- 25 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Cataract
Postoperative Rotational Dynamics of Three Toric Intraocular Lens Designs
This prospective comparative cohort study evaluates and compares postoperative rotational stability and time-course dynamics of three commercially available toric intraocular lenses (TECNIS Toric II [ZCU], AcrySof IQ Toric, and…
- Trial name
- 3 TORIC ROTATE (NCT07453992)
- Testing
- TECNIS Toric II (ZCU), AcrySof IQ Toric, AT TORBI 709M
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Jin Yang
Cataract
Evaluate the Safety and Effectiveness of the enVista® One-Piece Hydrophobic Acrylic Trifocal Intraocular Lens
The objective of the study is to evaluate the safety and effectiveness of the enVista trifocal intraocular lens when implanted in the capsular bag.
- Trial name
- NCT03603600
- Testing
- enVista MX60E, enVista MX60EF
- Where
- 23 sites in United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
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